NAT10 — 131 ClinVar variants
All ClinVar germline NAT10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
9 Benign · 3 Likely benign · 119 Uncertain significance
Full NAT10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NAT10 p.Asn132Asp Uncertain significance Multiple submitters
- NAT10 p.Ala218Pro Uncertain significance Single submitter
- NAT10 p.Ala218Thr Uncertain significance Single submitter
- NAT10 p.Ala285Ser Uncertain significance Single submitter
- NAT10 p.Ala452Val Uncertain significance Single submitter
- NAT10 p.Ala472Ser Uncertain significance Single submitter
- NAT10 p.Ala472Thr Uncertain significance Single submitter
- NAT10 p.Ala531Thr Uncertain significance Single submitter
- NAT10 p.Ala913Thr Uncertain significance Single submitter
- NAT10 p.Ala979Val Uncertain significance Single submitter
- NAT10 p.Ala98Thr Uncertain significance Single submitter
- NAT10 p.Ala98Val Uncertain significance Single submitter
- NAT10 p.Arg1023Trp Uncertain significance Single submitter
- NAT10 p.Arg170Ser Uncertain significance Single submitter
- NAT10 p.Arg288Gln Uncertain significance Single submitter
- NAT10 p.Arg421Trp Uncertain significance Single submitter
- NAT10 p.Arg458Trp Uncertain significance Single submitter
- NAT10 p.Arg494Gln Uncertain significance Single submitter
- NAT10 p.Arg528Trp Uncertain significance Single submitter
- NAT10 p.Arg52Gln Uncertain significance Single submitter
- NAT10 p.Arg655Ser Uncertain significance Single submitter
- NAT10 p.Arg688Trp Uncertain significance Single submitter
- NAT10 p.Arg725Gln Uncertain significance Single submitter
- NAT10 p.Arg824Gln Uncertain significance Single submitter
- NAT10 p.Arg824Gly Uncertain significance Single submitter
- NAT10 p.Arg824Trp Uncertain significance Single submitter
- NAT10 p.Arg966His Uncertain significance Single submitter
- NAT10 p.Asn699Asp Uncertain significance Single submitter
- NAT10 p.Asp1018Val Uncertain significance Single submitter
- NAT10 p.Asp232Val Uncertain significance Single submitter
- NAT10 p.Asp483Asn Uncertain significance Single submitter
- NAT10 p.Asp483Gly Uncertain significance Single submitter
- NAT10 p.Asp544Gly Uncertain significance Single submitter
- NAT10 p.Asp615Asn Uncertain significance Single submitter
- NAT10 p.Asp991Gly Uncertain significance Single submitter
- NAT10 p.Gln203Arg Uncertain significance Single submitter
- NAT10 p.Gln246Glu Uncertain significance Single submitter
- NAT10 p.Glu240Asp Uncertain significance Single submitter
- NAT10 p.Glu363Asp Uncertain significance Single submitter
- NAT10 p.Glu503Lys Uncertain significance Single submitter
- NAT10 p.Glu951Gly Uncertain significance Single submitter
- NAT10 p.Gly229Arg Uncertain significance Single submitter
- NAT10 p.Gly30Glu Uncertain significance Single submitter
- NAT10 p.Gly710Ala Uncertain significance Single submitter
- NAT10 p.Gly727Ala Uncertain significance Single submitter
- NAT10 p.Gly762Ser Uncertain significance Single submitter
- NAT10 p.Gly855Glu Uncertain significance Single submitter
- NAT10 p.Gly953Val Uncertain significance Single submitter
- NAT10 p.His948Arg Uncertain significance Single submitter
- NAT10 p.Ile268Val Uncertain significance Single submitter
- NAT10 p.Ile371Thr Uncertain significance Single submitter
- NAT10 p.Ile387Thr Uncertain significance Single submitter
- NAT10 p.Ile39Val Uncertain significance Single submitter
- NAT10 p.Ile492Val Uncertain significance Single submitter
- NAT10 p.Ile495Met Uncertain significance Single submitter
- NAT10 p.Ile898Leu Uncertain significance Single submitter
- NAT10 p.Leu1021Val Uncertain significance Single submitter
- NAT10 p.Leu204His Uncertain significance Single submitter
- NAT10 p.Leu427Val Uncertain significance Single submitter
- NAT10 p.Leu431Phe Uncertain significance Single submitter
- NAT10 p.Leu960Phe Uncertain significance Single submitter
- NAT10 p.Lys1024Glu Uncertain significance Single submitter
- NAT10 p.Lys901Glu Uncertain significance Single submitter
- NAT10 p.Lys950Gln Uncertain significance Single submitter
- NAT10 p.Met530Val Uncertain significance Single submitter
- NAT10 p.Met827Leu Uncertain significance Single submitter
- NAT10 p.Met839Thr Uncertain significance Single submitter
- NAT10 p.Phe330Ser Uncertain significance Single submitter
- NAT10 p.Phe557Leu Uncertain significance Single submitter
- NAT10 p.Phe96Ser Uncertain significance Single submitter
- NAT10 p.Pro542Leu Uncertain significance Single submitter
- NAT10 p.Pro702Thr Uncertain significance Single submitter
- NAT10 p.Pro981Leu Uncertain significance Single submitter
- NAT10 p.Ser231Cys Uncertain significance Single submitter
- NAT10 p.Ser45Phe Uncertain significance Single submitter
- NAT10 p.Thr215Ala Uncertain significance Single submitter
- NAT10 p.Thr279Ile Uncertain significance Single submitter
- NAT10 p.Thr450Met Uncertain significance Single submitter
- NAT10 p.Thr686Ser Uncertain significance Single submitter
- NAT10 p.Thr751Met Uncertain significance Single submitter
- NAT10 p.Val122Ala Uncertain significance Single submitter
- NAT10 p.Val138Ile Uncertain significance Single submitter
- NAT10 p.Val248Met Uncertain significance Single submitter
- NAT10 p.Val252Met Uncertain significance Single submitter
- NAT10 p.Val29Ala Uncertain significance Single submitter
- NAT10 p.Val663Ala Uncertain significance Single submitter
- NAT10 p.Val711Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- NAT10 p.Ala263Val Uncertain significance Single submitter
- NAT10 p.Ala301Val Uncertain significance Single submitter
- NAT10 p.Arg587Cys Uncertain significance Single submitter
- NAT10 p.Arg688Gln Uncertain significance Single submitter
- NAT10 p.Arg773Trp Uncertain significance Single submitter
- NAT10 p.Arg897Gln Uncertain significance Single submitter
- NAT10 p.Asn308Ser Uncertain significance Single submitter
- NAT10 p.His68Gln Uncertain significance Single submitter
- NAT10 p.Ile870Thr Uncertain significance Single submitter
- NAT10 p.Leu13Phe Uncertain significance Single submitter
- NAT10 p.Leu647Gln Uncertain significance Single submitter
- NAT10 p.Lys112Asn Uncertain significance Single submitter
- NAT10 p.Lys721Asn Uncertain significance Single submitter
- NAT10 p.Ser642Arg Uncertain significance Single submitter
- NAT10 p.Ser987Arg Uncertain significance Single submitter
- NAT10 p.Thr736Ile Uncertain significance Single submitter
- NAT10 p.Thr741Ile Uncertain significance Single submitter
- NAT10 p.Thr932Ile Uncertain significance Single submitter
- NAT10 p.Tyr533Cys Uncertain significance Single submitter
- NAT10 p.Val199Leu Uncertain significance Single submitter
- NAT10 p.Val627Ile Uncertain significance Single submitter
- NAT10 p.Val902Ala Uncertain significance Single submitter
All NAT10 variants
Benign 9
- c.2885+6G>C Multiple submitters
- c.373-7C>T Multiple submitters
- p.Ala983Thr Multiple submitters
- p.Gln203= Multiple submitters
- p.Pro224Leu Multiple submitters
- p.Pro562= Multiple submitters
- p.Thr153= Multiple submitters
- p.Leu123= Single submitter
- p.Tyr59= Single submitter
Likely benign 3
- p.Thr929Met Multiple submitters
- p.Ala921Val Single submitter
- p.Asp91= Single submitter
Uncertain significance 119
- p.Asn132Asp Multiple submitters ⚠
- p.Ala218Pro Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala263Val Single submitter ⚠
- p.Ala285Ser Single submitter ⚠
- p.Ala301Val Single submitter ⚠
- p.Ala452Val Single submitter ⚠
- p.Ala472Ser Single submitter ⚠
- p.Ala472Thr Single submitter ⚠
- p.Ala531Thr Single submitter ⚠
- p.Ala913Thr Single submitter ⚠
- p.Ala979Val Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg1023Trp Single submitter ⚠
- p.Arg170Ser Single submitter ⚠
- p.Arg288Gln Single submitter ⚠
- p.Arg3Trp Single submitter
- p.Arg421Trp Single submitter ⚠
- p.Arg432His Single submitter
- p.Arg458Trp Single submitter ⚠
- p.Arg494Gln Single submitter ⚠
- p.Arg528Trp Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg587Cys Single submitter ⚠
- p.Arg655Ser Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Arg688Trp Single submitter ⚠
- p.Arg725Gln Single submitter ⚠
- p.Arg773Trp Single submitter ⚠
- p.Arg824Gln Single submitter ⚠
- p.Arg824Gly Single submitter ⚠
- p.Arg824Trp Single submitter ⚠
- p.Arg897Gln Single submitter ⚠
- p.Arg900His Single submitter
- p.Arg966His Single submitter ⚠
- p.Asn308Ser Single submitter ⚠
- p.Asn699Asp Single submitter ⚠
- p.Asp1018Val Single submitter ⚠
- p.Asp232Val Single submitter ⚠
- p.Asp483Asn Single submitter ⚠
- p.Asp483Gly Single submitter ⚠
- p.Asp544Gly Single submitter ⚠
- p.Asp615Asn Single submitter ⚠
- p.Asp739Gly Single submitter
- p.Asp991Gly Single submitter ⚠
- p.Gln203Arg Single submitter ⚠
- p.Gln246Glu Single submitter ⚠
- p.Glu240Asp Single submitter ⚠
- p.Glu363Asp Single submitter ⚠
- p.Glu503Lys Single submitter ⚠
- p.Glu951Gly Single submitter ⚠
- p.Gly229Arg Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Gly710Ala Single submitter ⚠
- p.Gly727Ala Single submitter ⚠
- p.Gly762Ser Single submitter ⚠
- p.Gly855Glu Single submitter ⚠
- p.Gly953Val Single submitter ⚠
- p.His68Gln Single submitter ⚠
- p.His948Arg Single submitter ⚠
- p.Ile268Val Single submitter ⚠
- p.Ile371Thr Single submitter ⚠
- p.Ile387Thr Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile492Val Single submitter ⚠
- p.Ile495Met Single submitter ⚠
- p.Ile870Thr Single submitter ⚠
- p.Ile898Leu Single submitter ⚠
- p.Leu1021Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu204His Single submitter ⚠
- p.Leu427Val Single submitter ⚠
- p.Leu431Phe Single submitter ⚠
- p.Leu647Gln Single submitter ⚠
- p.Leu960Phe Single submitter ⚠
- p.Lys1024Glu Single submitter ⚠
- p.Lys112Asn Single submitter ⚠
- p.Lys721Asn Single submitter ⚠
- p.Lys901Glu Single submitter ⚠
- p.Lys950Gln Single submitter ⚠
- p.Met530Val Single submitter ⚠
- p.Met827Leu Single submitter ⚠
- p.Met839Thr Single submitter ⚠
- p.Phe330Ser Single submitter ⚠
- p.Phe557Leu Single submitter ⚠
- p.Phe96Ser Single submitter ⚠
- p.Pro542Leu Single submitter ⚠
- p.Pro702Thr Single submitter ⚠
- p.Pro981Leu Single submitter ⚠
- p.Ser156Ala Single submitter
- p.Ser231Cys Single submitter ⚠
- p.Ser45Phe Single submitter ⚠
- p.Ser642Arg Single submitter ⚠
- p.Ser987Arg Single submitter ⚠
- p.Thr162Ile Single submitter
- p.Thr215Ala Single submitter ⚠
- p.Thr279Ile Single submitter ⚠
- p.Thr450Met Single submitter ⚠
- p.Thr686Ser Single submitter ⚠
- p.Thr736Ile Single submitter ⚠
- p.Thr741Ile Single submitter ⚠
- p.Thr751Met Single submitter ⚠
- p.Thr932Ile Single submitter ⚠
- p.Tyr106Cys Single submitter
- p.Tyr106His Single submitter
- p.Tyr533Cys Single submitter ⚠
- p.Val122Ala Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val199Leu Single submitter ⚠
- p.Val248Met Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val29Ala Single submitter ⚠
- p.Val463Phe Single submitter
- p.Val627Ile Single submitter ⚠
- p.Val663Ala Single submitter ⚠
- p.Val711Ala Single submitter ⚠
- p.Val902Ala Single submitter ⚠
- p.Leu808= No assertion criteria