NCBP1 — 73 ClinVar variants
All ClinVar germline NCBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
1 Benign · 72 Uncertain significance
Full NCBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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NCBP1 p.Val125Met
Uncertain significance
Multiple submitters
Mycotic Aneurysm, Intracranial
- NCBP1 p.Ala141Ser Uncertain significance Single submitter
- NCBP1 p.Ala24Val Uncertain significance Single submitter
- NCBP1 p.Ala475Thr Uncertain significance Single submitter
- NCBP1 p.Arg166Gln Uncertain significance Single submitter
- NCBP1 p.Arg401His Uncertain significance Single submitter
- NCBP1 p.Arg610Cys Uncertain significance Single submitter
- NCBP1 p.Arg630Cys Uncertain significance Single submitter
- NCBP1 p.Arg672Gln Uncertain significance Single submitter
- NCBP1 p.Arg673Gln Uncertain significance Single submitter
- NCBP1 p.Arg683Lys Uncertain significance Single submitter
- NCBP1 p.Arg694Gln Uncertain significance Single submitter
- NCBP1 p.Arg70Ser Uncertain significance Single submitter
- NCBP1 p.Arg716Trp Uncertain significance Single submitter
- NCBP1 p.Asn317Ser Uncertain significance Single submitter
- NCBP1 p.Asn348Thr Uncertain significance Single submitter
- NCBP1 p.Asn526Ser Uncertain significance Single submitter
- NCBP1 p.Asn596Lys Uncertain significance Single submitter
- NCBP1 p.Asn649Ser Uncertain significance Single submitter
- NCBP1 p.Asp403Asn Uncertain significance Single submitter
- NCBP1 p.Asp606Gly Uncertain significance Single submitter
- NCBP1 p.Asp678Tyr Uncertain significance Single submitter
- NCBP1 p.Gln361His Uncertain significance Single submitter
- NCBP1 p.Glu316Gly Uncertain significance Single submitter
- NCBP1 p.Glu454Gln Uncertain significance Single submitter
- NCBP1 p.Glu578Gln Uncertain significance Single submitter
- NCBP1 p.Gly341Glu Uncertain significance Single submitter
- NCBP1 p.His276Tyr Uncertain significance Single submitter
- NCBP1 p.His325Tyr Uncertain significance Single submitter
- NCBP1 p.His553Arg Uncertain significance Single submitter
- NCBP1 p.Ile322Val Uncertain significance Single submitter
- NCBP1 p.Ile692Met Uncertain significance Single submitter
- NCBP1 p.Ile713Val Uncertain significance Single submitter
- NCBP1 p.Ile720Val Uncertain significance Single submitter
- NCBP1 p.Leu504Val Uncertain significance Single submitter
- NCBP1 p.Leu653Val Uncertain significance Single submitter
- NCBP1 p.Lys511Arg Uncertain significance Single submitter
- NCBP1 p.Phe636Tyr Uncertain significance Single submitter
- NCBP1 p.Pro366Ser Uncertain significance Single submitter
- NCBP1 p.Pro541Leu Uncertain significance Single submitter
- NCBP1 p.Pro776Leu Uncertain significance Single submitter
- NCBP1 p.Pro776Thr Uncertain significance Single submitter
- NCBP1 p.Ser154Gly Uncertain significance Single submitter
- NCBP1 p.Ser154Thr Uncertain significance Single submitter
- NCBP1 p.Ser201Asn Uncertain significance Single submitter
- NCBP1 p.Ser201Gly Uncertain significance Single submitter
- NCBP1 p.Ser674Asn Uncertain significance Single submitter
- NCBP1 p.Tyr185His Uncertain significance Single submitter
- NCBP1 p.Val155Ala Uncertain significance Single submitter
- NCBP1 p.Val170Leu Uncertain significance Single submitter
- NCBP1 p.Val211Gly Uncertain significance Single submitter
- NCBP1 p.Val352Ile Uncertain significance Single submitter
- NCBP1 p.Val452Ile Uncertain significance Single submitter
- NCBP1 p.Val699Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- NCBP1 p.Ala394Val Uncertain significance Single submitter
- NCBP1 p.Ala501Thr Uncertain significance Single submitter
- NCBP1 p.Arg129His Uncertain significance Single submitter
- NCBP1 p.Asp133Glu Uncertain significance Single submitter
- NCBP1 p.Asp440Tyr Uncertain significance Single submitter
- NCBP1 p.His651Arg Uncertain significance Single submitter
- NCBP1 p.Met148Thr Uncertain significance Single submitter
- NCBP1 p.Phe152Ile Uncertain significance Single submitter
- NCBP1 p.Pro80Thr Uncertain significance Single submitter
- NCBP1 p.Thr374Ile Uncertain significance Single submitter
All NCBP1 variants
Benign 1
- p.Arg3= Single submitter
Uncertain significance 72
- p.Val125Met Multiple submitters Mycotic Aneurysm, Intracranial ⚠
- p.Ala141Ser Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala475Thr Single submitter ⚠
- p.Ala501Thr Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg401His Single submitter ⚠
- p.Arg610Cys Single submitter ⚠
- p.Arg630Cys Single submitter ⚠
- p.Arg672Gln Single submitter ⚠
- p.Arg673Gln Single submitter ⚠
- p.Arg683Lys Single submitter ⚠
- p.Arg694Gln Single submitter ⚠
- p.Arg70Ser Single submitter ⚠
- p.Arg716Trp Single submitter ⚠
- p.Arg727Gly Single submitter
- p.Asn317Ser Single submitter ⚠
- p.Asn348Thr Single submitter ⚠
- p.Asn526Ser Single submitter ⚠
- p.Asn596Lys Single submitter ⚠
- p.Asn649Ser Single submitter ⚠
- p.Asp133Glu Single submitter ⚠
- p.Asp189Glu Single submitter
- p.Asp403Asn Single submitter ⚠
- p.Asp435Tyr Single submitter
- p.Asp440Tyr Single submitter ⚠
- p.Asp606Gly Single submitter ⚠
- p.Asp678Tyr Single submitter ⚠
- p.Gln163Arg Single submitter
- p.Gln361His Single submitter ⚠
- p.Gln463Leu Single submitter
- p.Glu316Gly Single submitter ⚠
- p.Glu454Gln Single submitter ⚠
- p.Glu578Gln Single submitter ⚠
- p.Glu766Gln Single submitter
- p.Gly341Glu Single submitter ⚠
- p.His276Tyr Single submitter ⚠
- p.His325Tyr Single submitter ⚠
- p.His553Arg Single submitter ⚠
- p.His651Arg Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Ile544Thr Single submitter
- p.Ile692Met Single submitter ⚠
- p.Ile713Val Single submitter ⚠
- p.Ile720Val Single submitter ⚠
- p.Leu504Val Single submitter ⚠
- p.Leu653Val Single submitter ⚠
- p.Lys511Arg Single submitter ⚠
- p.Met148Thr Single submitter ⚠
- p.Met1Val Single submitter
- p.Phe152Ile Single submitter ⚠
- p.Phe636Tyr Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro541Leu Single submitter ⚠
- p.Pro776Leu Single submitter ⚠
- p.Pro776Thr Single submitter ⚠
- p.Pro80Thr Single submitter ⚠
- p.Ser154Gly Single submitter ⚠
- p.Ser154Thr Single submitter ⚠
- p.Ser201Asn Single submitter ⚠
- p.Ser201Gly Single submitter ⚠
- p.Ser674Asn Single submitter ⚠
- p.Thr374Ile Single submitter ⚠
- p.Tyr185His Single submitter ⚠
- p.Val155Ala Single submitter ⚠
- p.Val170Leu Single submitter ⚠
- p.Val211Gly Single submitter ⚠
- p.Val352Ile Single submitter ⚠
- p.Val452Ile Single submitter ⚠
- p.Val699Gly Single submitter ⚠