NCBP2 — 12 ClinVar variants
All ClinVar germline NCBP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 11 Uncertain significance
Full NCBP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NCBP2 p.Ala97Val Uncertain significance Single submitter
- NCBP2 p.Arg105Pro Uncertain significance Single submitter
- NCBP2 p.Arg109Gln Uncertain significance Single submitter
- NCBP2 p.Glu121Asp Uncertain significance Single submitter
- NCBP2 p.Glu58Lys Uncertain significance Single submitter
- NCBP2 p.Gly147Arg Uncertain significance Single submitter
- NCBP2 p.Leu5Val Uncertain significance Single submitter
- NCBP2 p.Val15Met Uncertain significance Single submitter
- NCBP2 p.Val44Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All NCBP2 variants
Likely benign 1
- p.Thr41= Single submitter
Uncertain significance 11
- p.Ala97Val Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg105Pro Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Val15Met Single submitter ⚠
- p.Val44Ala Single submitter ⚠