NCK1 — 29 ClinVar variants
All ClinVar germline NCK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 1 Likely benign · 27 Uncertain significance
Full NCK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NCK1 p.Ala2Gly Uncertain significance Single submitter
- NCK1 p.Arg145Cys Uncertain significance Single submitter
- NCK1 p.Asn149Ser Uncertain significance Single submitter
- NCK1 p.Asn185Thr Uncertain significance Single submitter
- NCK1 p.Asn60Ser Uncertain significance Single submitter
- NCK1 p.Asp218Asn Uncertain significance Single submitter
- NCK1 p.Asp33Gly Uncertain significance Single submitter
- NCK1 p.Cys266Tyr Uncertain significance Single submitter
- NCK1 p.Gln333His Uncertain significance Single submitter
- NCK1 p.Glu354Gly Uncertain significance Single submitter
- NCK1 p.His171Arg Uncertain significance Single submitter
- NCK1 p.Ile269Phe Uncertain significance Single submitter
- NCK1 p.Leu273Phe Uncertain significance Single submitter
- NCK1 p.Met349Leu Uncertain significance Single submitter
- NCK1 p.Ser166Gly Uncertain significance Single submitter
- NCK1 p.Ser202Gly Uncertain significance Single submitter
- NCK1 p.Ser91Phe Uncertain significance Single submitter
- NCK1 p.Thr131Ala Uncertain significance Single submitter
- NCK1 p.Thr48Ile Uncertain significance Single submitter
- NCK1 p.Val135Ile Uncertain significance Single submitter
- NCK1 p.Val319Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NCK1 variants
Benign 1
- p.Gly258Arg Multiple submitters
Likely benign 1
- p.Ser203= Single submitter
Uncertain significance 27
- p.Ala292Thr Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Arg145Cys Single submitter ⚠
- p.Arg63Gln Single submitter
- p.Asn149Ser Single submitter ⚠
- p.Asn185Thr Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Asp218Asn Single submitter ⚠
- p.Asp33Gly Single submitter ⚠
- p.Cys266Tyr Single submitter ⚠
- p.Gln333His Single submitter ⚠
- p.Glu207Ala Single submitter ⚠
- p.Glu354Gly Single submitter ⚠
- p.Gly325Arg Single submitter ⚠
- p.His171Arg Single submitter ⚠
- p.Ile269Phe Single submitter ⚠
- p.Leu273Phe Single submitter ⚠
- p.Lys64Glu Single submitter ⚠
- p.Met349Leu Single submitter ⚠
- p.Ser166Gly Single submitter ⚠
- p.Ser202Gly Single submitter ⚠
- p.Ser91Phe Single submitter ⚠
- p.Thr131Ala Single submitter ⚠
- p.Thr48Ile Single submitter ⚠
- p.Tyr371His Single submitter ⚠
- p.Val135Ile Single submitter ⚠
- p.Val319Ile Single submitter ⚠