NCOA2 — 177 ClinVar variants

All ClinVar germline NCOA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →

2 Benign · 1 Benign/Likely benign · 7 Likely benign · 167 Uncertain significance

Full NCOA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 161

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 138

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All NCOA2 variants

Benign 2

p.Glu6= Multiple submitters
p.Pro1222= Multiple submitters

Benign/Likely benign 1

p.Ser551= Multiple submitters

Likely benign 7

p.Val1132Ile Multiple submitters
p.Asp714Glu Single submitter
p.Gly1362= Single submitter
p.Ile730Val Single submitter
p.Lys78= Single submitter
p.Ser282= Single submitter
p.Thr1001Met Single submitter

Uncertain significance 167

p.Ala1130Val Single submitter ⚠
p.Ala1199Ser Single submitter ⚠
p.Ala1228Val Single submitter ⚠
p.Ala1296Thr Single submitter ⚠
p.Ala1379Val Single submitter ⚠
p.Ala1395Val Single submitter ⚠
p.Ala407Val Single submitter ⚠
p.Ala600Gly Single submitter ⚠
p.Ala776Val Single submitter ⚠
p.Ala862Thr Single submitter ⚠
p.Ala899Val Single submitter ⚠
p.Ala955Thr Single submitter ⚠
p.Arg1088Trp Single submitter ⚠
p.Arg1169His Single submitter ⚠
p.Arg1248Gln Single submitter ⚠
p.Arg1261Gln Single submitter ⚠
p.Arg1329Gln Single submitter ⚠
p.Arg13Gly Single submitter ⚠
p.Arg193Trp Single submitter
p.Arg273Gly Single submitter ⚠
p.Arg338His Single submitter ⚠
p.Arg501Gly Single submitter ⚠
p.Arg631Gly Single submitter ⚠
p.Arg768Ile Single submitter ⚠
p.Arg880Thr Single submitter ⚠
p.Arg946Gln Single submitter ⚠
p.Arg946Leu Single submitter ⚠
p.Asn1344Ser Single submitter ⚠
p.Asn1354Ser Single submitter ⚠
p.Asn135Ser Single submitter ⚠
p.Asn1391Ile Single submitter ⚠
p.Asn1433Ser Single submitter ⚠
p.Asn1441Thr Single submitter ⚠
p.Asn217Asp Single submitter ⚠
p.Asn568His Single submitter ⚠
p.Asn568Ser Single submitter ⚠
p.Asn871Ser Single submitter ⚠
p.Asp111Asn Single submitter ⚠
p.Asp167Asn Single submitter ⚠
p.Asp216Asn Single submitter ⚠
p.Asp584Asn Single submitter ⚠
p.Asp627Gly Single submitter ⚠
p.Asp824Glu Single submitter ⚠
p.Gln1003Arg Single submitter ⚠
p.Gln1022His Single submitter ⚠
p.Gln1054His Single submitter ⚠
p.Gln1339Lys Single submitter
p.Gln1369Arg Single submitter ⚠
p.Gln1431Arg Single submitter
p.Gln433Glu Single submitter ⚠
p.Gln454Glu Single submitter ⚠
p.Gln454Leu Single submitter ⚠
p.Gln563His Single submitter ⚠
p.Glu1013Asp Single submitter ⚠
p.Glu1095Asp Single submitter ⚠
p.Glu219Asp Single submitter ⚠
p.Glu611Asp Single submitter ⚠
p.Glu718Lys Single submitter ⚠
p.Glu96Asp Single submitter ⚠
p.Gly1077Ala Single submitter ⚠
p.Gly1400Val Single submitter ⚠
p.Gly429Asp Single submitter ⚠
p.Gly495Ala Single submitter ⚠
p.Gly498Asp Single submitter ⚠
p.Gly549Glu Single submitter ⚠
p.Gly607Glu Single submitter ⚠
p.Gly758Asp Single submitter ⚠
p.His196Arg Single submitter ⚠
p.His215Arg Single submitter ⚠
p.His324Arg Single submitter ⚠
p.His605Tyr Single submitter ⚠
p.His679Arg Single submitter ⚠
p.Ile1009Val Single submitter ⚠
p.Ile1043Val Single submitter ⚠
p.Ile1124Val Single submitter ⚠
p.Ile427Val Single submitter ⚠
p.Ile46Met Single submitter ⚠
p.Ile839Thr Single submitter ⚠
p.Ile840Val Single submitter ⚠
p.Ile981Thr Single submitter ⚠
p.Leu1002Pro Single submitter ⚠
p.Leu1263Ser Single submitter ⚠
p.Leu1270Ser Single submitter ⚠
p.Leu154Met Single submitter ⚠
p.Leu341Ser Single submitter ⚠
p.Leu346Pro Single submitter ⚠
p.Leu552Phe Single submitter ⚠
p.Leu632Pro Single submitter ⚠
p.Leu672Phe Single submitter ⚠
p.Leu813Phe Single submitter ⚠
p.Leu846Phe Single submitter ⚠
p.Lys178Glu Single submitter ⚠
p.Lys466Asn Single submitter ⚠
p.Lys636Arg Single submitter ⚠
p.Lys738Glu Single submitter ⚠
p.Lys739Glu Single submitter
p.Met1016Ile Single submitter ⚠
p.Met1207Thr Single submitter ⚠
p.Met1264Leu Single submitter ⚠
p.Met1276Val Single submitter ⚠
p.Met1361Leu Single submitter ⚠
p.Met1361Val Single submitter ⚠
p.Met1366Val Single submitter ⚠
p.Met1427Val Single submitter ⚠
p.Met1450Leu Single submitter ⚠
p.Met1452Val Single submitter ⚠
p.Met288Leu Single submitter ⚠
p.Met382Val Single submitter ⚠
p.Met436Val Single submitter ⚠
p.Met438Ile Single submitter ⚠
p.Met438Val Single submitter ⚠
p.Met577Leu Single submitter ⚠
p.Met980Val Single submitter ⚠
p.Phe822Leu Single submitter ⚠
p.Pro1029Leu Single submitter
p.Pro1030Arg Single submitter ⚠
p.Pro1035Leu Single submitter ⚠
p.Pro1055Leu Single submitter ⚠
p.Pro1222Leu Single submitter ⚠
p.Pro1292Thr Single submitter ⚠
p.Pro1300Gln Single submitter ⚠
p.Pro1311Ser Single submitter ⚠
p.Pro235Ala Single submitter ⚠
p.Pro384Leu Single submitter ⚠
p.Pro413Leu Single submitter ⚠
p.Pro437Leu Single submitter ⚠
p.Pro458Leu Single submitter ⚠
p.Pro494Arg Single submitter ⚠
p.Pro509Ser Single submitter
p.Pro573Arg Single submitter ⚠
p.Pro619Leu Single submitter ⚠
p.Pro654Leu Single submitter ⚠
p.Pro654Thr Single submitter ⚠
p.Pro673Arg Single submitter ⚠
p.Pro896Gln Single submitter ⚠
p.Pro904Ala Single submitter ⚠
p.Ser1107Asn Single submitter ⚠
p.Ser315Ala Single submitter ⚠
p.Ser444Pro Single submitter ⚠
p.Ser461Gly Single submitter ⚠
p.Ser471Leu Single submitter ⚠
p.Ser493Asn Single submitter ⚠
p.Ser499Arg Single submitter ⚠
p.Ser522Arg Single submitter ⚠
p.Ser551Leu Single submitter ⚠
p.Ser726Pro Single submitter ⚠
p.Ser816Gly Single submitter ⚠
p.Ser959Leu Single submitter ⚠
p.Ser987Gly Single submitter ⚠
p.Thr1319Ala Single submitter ⚠
p.Thr1320Ser Single submitter ⚠
p.Thr34Ala Single submitter ⚠
p.Thr597Ala Single submitter ⚠
p.Thr729Ala Single submitter ⚠
p.Thr729Asn Single submitter ⚠
p.Thr754Ile Single submitter ⚠
p.Tyr1165Cys Single submitter ⚠
p.Tyr463Cys Single submitter ⚠
p.Tyr529His Single submitter ⚠
p.Val1132Ala Single submitter ⚠
p.Val136Ile Single submitter ⚠
p.Val1392Met Single submitter ⚠
p.Val204Ile Single submitter ⚠
p.Val379Ala Single submitter ⚠
p.Val517Met Single submitter ⚠
p.Val546Phe Single submitter ⚠
p.Val961Met Single submitter ⚠