Sugi Variant

Sugi Variant/NDE1

NDE1 — 252 ClinVar variants

All ClinVar germline NDE1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

7 Pathogenic · 1 Pathogenic/Likely pathogenic · 1 Likely pathogenic · 17 Conflicting · 32 Benign · 3 Benign/Likely benign · 55 Likely benign · 136 Uncertain significance

Full NDE1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 66

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All NDE1 variants

Pathogenic 7

Pathogenic/Likely pathogenic 1

Likely pathogenic 1

Conflicting classifications of pathogenicity 17

Benign 32

Benign/Likely benign 3

Likely benign 55

Uncertain significance 136