NDUFA3 — 14 ClinVar variants
All ClinVar germline NDUFA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Likely benign · 13 Uncertain significance
Full NDUFA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NDUFA3 p.Arg58Cys Uncertain significance Single submitter
- NDUFA3 p.Gln74Glu Uncertain significance Single submitter
- NDUFA3 p.Gly61Arg Uncertain significance Single submitter
- NDUFA3 p.Gly75Asp Uncertain significance Single submitter
- NDUFA3 p.Leu35Val Uncertain significance Single submitter
- NDUFA3 p.Leu9Ile Uncertain significance Single submitter
- NDUFA3 p.Pro37Leu Uncertain significance Single submitter
- NDUFA3 p.Tyr41Cys Uncertain significance Single submitter
- NDUFA3 p.Val30Glu Uncertain significance Single submitter
- NDUFA3 p.Val66Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All NDUFA3 variants
Likely benign 1
- p.Val25Ile Single submitter
Uncertain significance 13
- p.Arg58Cys Single submitter ⚠
- p.Gln74Glu Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Gly61Arg Single submitter ⚠
- p.Gly75Asp Single submitter ⚠
- p.Leu35Val Single submitter ⚠
- p.Leu9Ile Single submitter ⚠
- p.Met44Val Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro76Ser Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Val30Glu Single submitter ⚠
- p.Val66Met Single submitter ⚠