Sugi Variant

Sugi Variant/NDUFB10

NDUFB10 — 90 ClinVar variants

All ClinVar germline NDUFB10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →

1 Pathogenic · 1 Likely pathogenic · 2 Conflicting · 6 Benign · 1 Benign/Likely benign · 23 Likely benign · 56 Uncertain significance

Full NDUFB10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 51

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 36

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All NDUFB10 variants

Pathogenic 1

  • p.Glu70Ter No assertion criteria mitochondrial complex 1 deficiency, nuclear type 35

Likely pathogenic 1

  • c.131-442G>C Single submitter mitochondrial complex I deficiency

Conflicting classifications of pathogenicity 2

Benign 6

Benign/Likely benign 1

Likely benign 23

Uncertain significance 56