NDUFB6 — 9 ClinVar variants
All ClinVar germline NDUFB6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
9 Uncertain significance
Full NDUFB6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NDUFB6 p.Arg103Ile Uncertain significance Single submitter
- NDUFB6 p.Asp108Gly Uncertain significance Single submitter
- NDUFB6 p.Ile69Val Uncertain significance Single submitter
- NDUFB6 p.Pro106Ser Uncertain significance Single submitter
- NDUFB6 p.Pro118Ala Uncertain significance Single submitter
- NDUFB6 p.Tyr65Cys Uncertain significance Single submitter
- NDUFB6 p.Tyr85Phe Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All NDUFB6 variants
Uncertain significance 9
- p.Arg103Ile Single submitter ⚠
- p.Asp108Gly Single submitter ⚠
- p.His89Arg Single submitter
- p.Ile69Val Single submitter ⚠
- p.Pro106Ser Single submitter ⚠
- p.Pro118Ala Single submitter ⚠
- p.Thr109Ala Single submitter ⚠
- p.Tyr65Cys Single submitter ⚠
- p.Tyr85Phe Single submitter ⚠