NEK10 — 116 ClinVar variants
All ClinVar germline NEK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
6 Pathogenic · 6 Likely pathogenic · 1 Conflicting · 12 Benign · 14 Likely benign · 77 Uncertain significance
Full NEK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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NEK10 p.Pro748Leu
Pathogenic
No assertion criteria
ciliary dyskinesia, primary, 44
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK10 p.Arg811Cys Uncertain significance Multiple submitters
- NEK10 p.Cys437Trp Uncertain significance Multiple submitters
- NEK10 p.Ala237Thr Uncertain significance Single submitter
- NEK10 p.Ala271Val Uncertain significance Single submitter
- NEK10 p.Arg103Cys Uncertain significance Single submitter
- NEK10 p.Arg103Ser Uncertain significance Single submitter
- NEK10 p.Arg221Gln Uncertain significance Single submitter
- NEK10 p.Arg329His Uncertain significance Single submitter
- NEK10 p.Arg378Gly Uncertain significance Single submitter
- NEK10 p.Arg476His Uncertain significance Single submitter
-
NEK10 p.Arg564Gln
Uncertain significance
Single submitter
ciliary dyskinesia, primary, 44
- NEK10 p.Arg65Met Uncertain significance Single submitter
- NEK10 p.Arg72Gln Uncertain significance Single submitter
- NEK10 p.Arg72Trp Uncertain significance Single submitter
- NEK10 p.Asn116Lys Uncertain significance Single submitter
- NEK10 p.Asn93Lys Uncertain significance Single submitter
- NEK10 p.Asp25Asn Uncertain significance Single submitter
- NEK10 p.Asp560Gly Uncertain significance Single submitter
- NEK10 p.Asp563Asn Uncertain significance Single submitter
- NEK10 p.Asp565Asn Uncertain significance Single submitter
- NEK10 p.Cys392Ser Uncertain significance Single submitter
- NEK10 p.Cys437Ser Uncertain significance Single submitter
- NEK10 p.Gln18His Uncertain significance Single submitter
- NEK10 p.Gln388His Uncertain significance Single submitter
- NEK10 p.Gln44Glu Uncertain significance Single submitter
- NEK10 p.Glu285Lys Uncertain significance Single submitter
- NEK10 p.Glu495Lys Uncertain significance Single submitter
- NEK10 p.Glu504Lys Uncertain significance Single submitter
- NEK10 p.Glu882Lys Uncertain significance Single submitter
- NEK10 p.Gly174Ser Uncertain significance Single submitter
- NEK10 p.Gly664Arg Uncertain significance Single submitter
- NEK10 p.His339Tyr Uncertain significance Single submitter
- NEK10 p.His406Leu Uncertain significance Single submitter
- NEK10 p.Ile251Val Uncertain significance Single submitter
- NEK10 p.Ile258Val Uncertain significance Single submitter
- NEK10 p.Ile293Met Uncertain significance Single submitter
- NEK10 p.Ile340Val Uncertain significance Single submitter
- NEK10 p.Ile499Thr Uncertain significance Single submitter
- NEK10 p.Ile521Val Uncertain significance Single submitter
- NEK10 p.Leu315Pro Uncertain significance Single submitter
- NEK10 p.Leu455Val Uncertain significance Single submitter
- NEK10 p.Leu496Pro Uncertain significance Single submitter
- NEK10 p.Met604Thr Uncertain significance Single submitter
-
NEK10 p.Pro128Ser
Uncertain significance
Single submitter
ciliary dyskinesia, primary, 44
- NEK10 p.Pro322Leu Uncertain significance Single submitter
- NEK10 p.Pro377His Uncertain significance Single submitter
- NEK10 p.Pro454Thr Uncertain significance Single submitter
- NEK10 p.Pro728Leu Uncertain significance Single submitter
- NEK10 p.Ser1068Asn Uncertain significance Single submitter
- NEK10 p.Ser235Asn Uncertain significance Single submitter
- NEK10 p.Ser386Leu Uncertain significance Single submitter
- NEK10 p.Ser60Phe Uncertain significance Single submitter
-
NEK10 p.Ser918Arg
Uncertain significance
Single submitter
ciliary dyskinesia, primary, 44
- NEK10 p.Thr416Ile Uncertain significance Single submitter
- NEK10 p.Trp123Ser Uncertain significance Single submitter
- NEK10 p.Val326Met Uncertain significance Single submitter
- NEK10 p.Val348Ile Uncertain significance Single submitter
-
NEK10 p.Val568Ile
Uncertain significance
Single submitter
NEK10-related disorder
Predictors split 14
The independent predictors disagree with each other — read with care.
- NEK10 p.Ala362Pro Uncertain significance Single submitter
- NEK10 p.Arg329Cys Uncertain significance Single submitter
- NEK10 p.Asp350Gly Uncertain significance Single submitter
- NEK10 p.Gln317His Uncertain significance Single submitter
- NEK10 p.Gln336His Uncertain significance Single submitter
- NEK10 p.Glu327Lys Uncertain significance Single submitter
- NEK10 p.Glu397Gln Uncertain significance Single submitter
-
NEK10 p.Gly333Val
Uncertain significance
Single submitter
ciliary dyskinesia, primary, 44
- NEK10 p.His131Gln Uncertain significance Single submitter
- NEK10 p.His473Pro Uncertain significance Single submitter
- NEK10 p.Ile328Thr Uncertain significance Single submitter
- NEK10 p.Leu233Val Uncertain significance Single submitter
- NEK10 p.Leu277Phe Uncertain significance Single submitter
- NEK10 p.Ser573Cys Uncertain significance Single submitter
All NEK10 variants
Pathogenic 6
- p.Met662Lys Single submitter primary ciliary dyskinesia
- p.Phe87fs Single submitter ciliary dyskinesia, primary, 44
- p.Ser386fs Single submitter ciliary dyskinesia, primary, 44
- p.Arg773Cys No assertion criteria ciliary dyskinesia, primary, 44
- p.His624fs No assertion criteria ciliary dyskinesia, primary, 44
- p.Pro748Leu No assertion criteria ciliary dyskinesia, primary, 44 ⚠
Likely pathogenic 6
- c.1230+5G>C Multiple submitters ciliary dyskinesia, primary, 44
- c.1028+1G>T Single submitter
- c.1743+1G>C Single submitter ciliary dyskinesia, primary, 44
- c.489+1G>A Single submitter ciliary dyskinesia, primary, 44
- p.Pro728Ser Single submitter ciliary dyskinesia, primary, 44
- p.Val326Ter Single submitter ciliary dyskinesia, primary, 44
Conflicting classifications of pathogenicity 1
- p.Tyr1094Ter Single submitter ciliary dyskinesia, primary, 44
Benign 12
- c.2505+22G>T Multiple submitters ciliary dyskinesia, primary, 44
- c.2869+140C>T Multiple submitters ciliary dyskinesia, primary, 44
- c.-37-9A>C Multiple submitters ciliary dyskinesia, primary, 44
- p.Asn401Ser Multiple submitters
- p.Asn597= Multiple submitters ciliary dyskinesia, primary, 44
- p.Asn659Ser Multiple submitters
- p.Gly558= Multiple submitters ciliary dyskinesia, primary, 44
- p.Leu513Ser Multiple submitters ciliary dyskinesia, primary, 44
- p.Thr670= Multiple submitters ciliary dyskinesia, primary, 44
- p.Thr687= Multiple submitters ciliary dyskinesia, primary, 44
- p.Val749= Multiple submitters ciliary dyskinesia, primary, 44
- p.Ala770Val Single submitter
Likely benign 14
- p.Lys425= Multiple submitters
- p.Val135= Multiple submitters
- c.1028+7A>G Single submitter
- c.2091-13184C>T Single submitter
- c.2291+14C>T Single submitter
- c.3243+6G>A Single submitter
- c.636+9C>G Single submitter
- p.Ala271= Single submitter
- p.Arg103His Single submitter
- p.Arg365Gln Single submitter
- p.Gly67Ser Single submitter
- p.His539Arg Single submitter
- p.Leu305= Single submitter
- p.Ser941= Single submitter
Uncertain significance 77
- p.Arg811Cys Multiple submitters ⚠
- p.Cys437Trp Multiple submitters ⚠
- c.2090+6G>A Single submitter
- p.Ala237Thr Single submitter ⚠
- p.Ala271Val Single submitter ⚠
- p.Ala362Pro Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg103Ser Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg329His Single submitter ⚠
- p.Arg378Gly Single submitter ⚠
- p.Arg476His Single submitter ⚠
- p.Arg564Gln Single submitter ciliary dyskinesia, primary, 44 ⚠
- p.Arg65Met Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Asn116Lys Single submitter ⚠
- p.Asn93Lys Single submitter ⚠
- p.Asp25Asn Single submitter ⚠
- p.Asp350Gly Single submitter ⚠
- p.Asp560Gly Single submitter ⚠
- p.Asp563Asn Single submitter ⚠
- p.Asp565Asn Single submitter ⚠
- p.Cys392Ser Single submitter ⚠
- p.Cys437Phe Single submitter
- p.Cys437Ser Single submitter ⚠
- p.Cys639Ser Single submitter
- p.Gln18His Single submitter ⚠
- p.Gln317His Single submitter ⚠
- p.Gln336His Single submitter ⚠
- p.Gln388His Single submitter ⚠
- p.Gln44Glu Single submitter ⚠
- p.Glu285Lys Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Glu397Gln Single submitter ⚠
- p.Glu495Lys Single submitter ⚠
- p.Glu504Lys Single submitter ⚠
- p.Glu882Lys Single submitter ⚠
- p.Gly174Ser Single submitter ⚠
- p.Gly333Val Single submitter ciliary dyskinesia, primary, 44 ⚠
- p.Gly664Arg Single submitter ⚠
- p.His131Gln Single submitter ⚠
- p.His339Tyr Single submitter ⚠
- p.His406Leu Single submitter ⚠
- p.His473Pro Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile258Val Single submitter ⚠
- p.Ile293Met Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile499Thr Single submitter ⚠
- p.Ile521Val Single submitter ⚠
- p.Leu233Val Single submitter ⚠
- p.Leu277Phe Single submitter ⚠
- p.Leu315Pro Single submitter ⚠
- p.Leu35Arg Single submitter
- p.Leu455Val Single submitter ⚠
- p.Leu496Pro Single submitter ⚠
- p.Leu513Ala Single submitter
- p.Met604Thr Single submitter ⚠
- p.Pro128Ser Single submitter ciliary dyskinesia, primary, 44 ⚠
- p.Pro322Leu Single submitter ⚠
- p.Pro377His Single submitter ⚠
- p.Pro454Thr Single submitter ⚠
- p.Pro728Leu Single submitter ⚠
- p.Ser1068Asn Single submitter ⚠
- p.Ser235Asn Single submitter ⚠
- p.Ser386Leu Single submitter ⚠
- p.Ser573Cys Single submitter ⚠
- p.Ser60Phe Single submitter ⚠
- p.Ser918Arg Single submitter ciliary dyskinesia, primary, 44 ⚠
- p.Thr416Ile Single submitter ⚠
- p.Trp123Ser Single submitter ⚠
- p.Val326Met Single submitter ⚠
- p.Val348Ile Single submitter ⚠
- p.Val568Ile Single submitter NEK10-related disorder ⚠