NEK11 — 98 ClinVar variants
All ClinVar germline NEK11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
2 Benign · 11 Likely benign · 85 Uncertain significance
Full NEK11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK11 p.Thr191Ile Uncertain significance Multiple submitters
- NEK11 p.Ala314Thr Uncertain significance Single submitter
- NEK11 p.Ala480Thr Uncertain significance Single submitter
- NEK11 p.Ala526Val Uncertain significance Single submitter
- NEK11 p.Arg114Gln Uncertain significance Single submitter
- NEK11 p.Arg381Gln Uncertain significance Single submitter
- NEK11 p.Arg381Trp Uncertain significance Single submitter
- NEK11 p.Arg570Leu Uncertain significance Single submitter
- NEK11 p.Arg605Cys Uncertain significance Single submitter
- NEK11 p.Asn163Ser Uncertain significance Single submitter
- NEK11 p.Asn518Lys Uncertain significance Single submitter
- NEK11 p.Asn533Asp Uncertain significance Single submitter
- NEK11 p.Asp118Asn Uncertain significance Single submitter
- NEK11 p.Asp389Glu Uncertain significance Single submitter
- NEK11 p.Asp431Glu Uncertain significance Single submitter
- NEK11 p.Asp448Asn Uncertain significance Single submitter
- NEK11 p.Cys105Phe Uncertain significance Single submitter
- NEK11 p.Cys186Phe Uncertain significance Single submitter
- NEK11 p.Cys310Gly Uncertain significance Single submitter
- NEK11 p.Cys487Gly Uncertain significance Single submitter
- NEK11 p.Gln207Arg Uncertain significance Single submitter
- NEK11 p.Gln385Arg Uncertain significance Single submitter
- NEK11 p.Gln577Lys Uncertain significance Single submitter
- NEK11 p.Gln5Lys Uncertain significance Single submitter
- NEK11 p.Glu100Gln Uncertain significance Single submitter
- NEK11 p.Glu259Gln Uncertain significance Single submitter
- NEK11 p.Glu467Gly Uncertain significance Single submitter
- NEK11 p.Glu492Asp Uncertain significance Single submitter
- NEK11 p.Glu55Gln Uncertain significance Single submitter
- NEK11 p.Glu586Lys Uncertain significance Single submitter
- NEK11 p.Glu601Lys Uncertain significance Single submitter
- NEK11 p.Gly13Val Uncertain significance Single submitter
- NEK11 p.Gly208Ala Uncertain significance Single submitter
- NEK11 p.Gly234Val Uncertain significance Single submitter
- NEK11 p.Gly536Asp Uncertain significance Single submitter
- NEK11 p.Gly536Val Uncertain significance Single submitter
- NEK11 p.His150Arg Uncertain significance Single submitter
- NEK11 p.His156Leu Uncertain significance Single submitter
- NEK11 p.His396Arg Uncertain significance Single submitter
- NEK11 p.Ile120Thr Uncertain significance Single submitter
- NEK11 p.Ile25Thr Uncertain significance Single submitter
- NEK11 p.Ile279Met Uncertain significance Single submitter
- NEK11 p.Ile497Met Uncertain significance Single submitter
- NEK11 p.Ile524Val Uncertain significance Single submitter
- NEK11 p.Leu143Pro Uncertain significance Single submitter
- NEK11 p.Leu144Pro Uncertain significance Single submitter
- NEK11 p.Leu260Pro Uncertain significance Single submitter
- NEK11 p.Leu260Val Uncertain significance Single submitter
- NEK11 p.Leu350Phe Uncertain significance Single submitter
- NEK11 p.Leu527Met Uncertain significance Single submitter
- NEK11 p.Lys22Glu Uncertain significance Single submitter
- NEK11 p.Lys258Glu Uncertain significance Single submitter
- NEK11 p.Lys504Arg Uncertain significance Single submitter
- NEK11 p.Lys578Arg Uncertain significance Single submitter
- NEK11 p.Met183Ile Uncertain significance Single submitter
- NEK11 p.Met228Lys Uncertain significance Single submitter
- NEK11 p.Met267Thr Uncertain significance Single submitter
- NEK11 p.Met568Ile Uncertain significance Single submitter
- NEK11 p.Phe176Cys Uncertain significance Single submitter
- NEK11 p.Phe559Tyr Uncertain significance Single submitter
- NEK11 p.Pro131Ser Uncertain significance Single submitter
- NEK11 p.Pro257Ser Uncertain significance Single submitter
- NEK11 p.Pro613Ser Uncertain significance Single submitter
- NEK11 p.Ser161Pro Uncertain significance Single submitter
- NEK11 p.Ser553Cys Uncertain significance Single submitter
- NEK11 p.Ser600Gly Uncertain significance Single submitter
- NEK11 p.Ser64Thr Uncertain significance Single submitter
- NEK11 p.Thr193Ala Uncertain significance Single submitter
- NEK11 p.Thr23Ala Uncertain significance Single submitter
- NEK11 p.Thr249Ala Uncertain significance Single submitter
- NEK11 p.Thr302Ile Uncertain significance Single submitter
- NEK11 p.Thr302Ser Uncertain significance Single submitter
- NEK11 p.Thr329Ala Uncertain significance Single submitter
- NEK11 p.Thr634Met Uncertain significance Single submitter
- NEK11 p.Val364Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- NEK11 p.Ala599Pro Uncertain significance Single submitter
- NEK11 p.Asp87Gly Uncertain significance Single submitter
- NEK11 p.Glu137Ala Uncertain significance Single submitter
- NEK11 p.Glu629Lys Uncertain significance Single submitter
- NEK11 p.Ile173Met Uncertain significance Single submitter
- NEK11 p.Met568Lys Benign Single submitter
- NEK11 p.Tyr588Cys Uncertain significance Single submitter
All NEK11 variants
Benign 2
- c.1399+13845A>G Single submitter
- p.Met568Lys Single submitter ⚠
Likely benign 11
- p.Ala498= Single submitter
- p.Ala498Val Single submitter
- p.Ala526= Single submitter
- p.Arg570His Single submitter
- p.Gln32= Single submitter
- p.Ile317Leu Single submitter
- p.Leu632= Single submitter
- p.Lys361= Single submitter
- p.Ser213= Single submitter
- p.Ser600= Single submitter
- p.Ser616= Single submitter
Uncertain significance 85
- p.Thr191Ile Multiple submitters ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala480Thr Single submitter ⚠
- p.Ala526Val Single submitter ⚠
- p.Ala599Pro Single submitter ⚠
- p.Arg114Gln Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg381Trp Single submitter ⚠
- p.Arg570Leu Single submitter ⚠
- p.Arg605Cys Single submitter ⚠
- p.Arg605Pro Single submitter
- p.Asn163Ser Single submitter ⚠
- p.Asn518Lys Single submitter ⚠
- p.Asn533Asp Single submitter ⚠
- p.Asp118Asn Single submitter ⚠
- p.Asp389Glu Single submitter ⚠
- p.Asp431Glu Single submitter ⚠
- p.Asp448Asn Single submitter ⚠
- p.Asp87Gly Single submitter ⚠
- p.Cys105Phe Single submitter ⚠
- p.Cys186Phe Single submitter ⚠
- p.Cys310Gly Single submitter ⚠
- p.Cys487Gly Single submitter ⚠
- p.Gln207Arg Single submitter ⚠
- p.Gln385Arg Single submitter ⚠
- p.Gln577Lys Single submitter ⚠
- p.Gln5Lys Single submitter ⚠
- p.Glu100Gln Single submitter ⚠
- p.Glu137Ala Single submitter ⚠
- p.Glu259Gln Single submitter ⚠
- p.Glu467Gly Single submitter ⚠
- p.Glu492Asp Single submitter ⚠
- p.Glu55Gln Single submitter ⚠
- p.Glu586Lys Single submitter ⚠
- p.Glu601Lys Single submitter ⚠
- p.Glu629Lys Single submitter ⚠
- p.Gly13Val Single submitter ⚠
- p.Gly208Ala Single submitter ⚠
- p.Gly234Val Single submitter ⚠
- p.Gly536Asp Single submitter ⚠
- p.Gly536Val Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.His156Leu Single submitter ⚠
- p.His396Arg Single submitter ⚠
- p.Ile120Thr Single submitter ⚠
- p.Ile173Met Single submitter ⚠
- p.Ile25Thr Single submitter ⚠
- p.Ile279Met Single submitter ⚠
- p.Ile497Met Single submitter ⚠
- p.Ile524Val Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu144Pro Single submitter ⚠
- p.Leu260Pro Single submitter ⚠
- p.Leu260Val Single submitter ⚠
- p.Leu350Phe Single submitter ⚠
- p.Leu527Met Single submitter ⚠
- p.Lys22Glu Single submitter ⚠
- p.Lys258Glu Single submitter ⚠
- p.Lys504Arg Single submitter ⚠
- p.Lys578Arg Single submitter ⚠
- p.Met183Ile Single submitter ⚠
- p.Met228Lys Single submitter ⚠
- p.Met267Thr Single submitter ⚠
- p.Met568Ile Single submitter ⚠
- p.Phe176Cys Single submitter ⚠
- p.Phe559Tyr Single submitter ⚠
- p.Pro131Ser Single submitter ⚠
- p.Pro257Ser Single submitter ⚠
- p.Pro613Ser Single submitter ⚠
- p.Ser161Pro Single submitter ⚠
- p.Ser39Ile Single submitter
- p.Ser553Cys Single submitter ⚠
- p.Ser600Gly Single submitter ⚠
- p.Ser616Arg Single submitter
- p.Ser64Thr Single submitter ⚠
- p.Thr108Ala Single submitter
- p.Thr193Ala Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Thr249Ala Single submitter ⚠
- p.Thr302Ile Single submitter ⚠
- p.Thr302Ser Single submitter ⚠
- p.Thr329Ala Single submitter ⚠
- p.Thr634Met Single submitter ⚠
- p.Tyr588Cys Single submitter ⚠
- p.Val364Leu Single submitter ⚠