Sugi Variant

Sugi Variant/NEK2

NEK2 — 277 ClinVar variants

All ClinVar germline NEK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 141 flagged for review →

4 Likely pathogenic · 7 Conflicting · 7 Benign · 6 Benign/Likely benign · 76 Likely benign · 177 Uncertain significance

Full NEK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 141

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 107

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All NEK2 variants

Likely pathogenic 4

Conflicting classifications of pathogenicity 7

Benign 7

Benign/Likely benign 6

Likely benign 76

Uncertain significance 177