NEK3 — 75 ClinVar variants
All ClinVar germline NEK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Benign · 5 Likely benign · 68 Uncertain significance
Full NEK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK3 p.Ala204Val Uncertain significance Single submitter
- NEK3 p.Ala258Val Uncertain significance Single submitter
- NEK3 p.Ala71Gly Uncertain significance Single submitter
- NEK3 p.Arg122Cys Uncertain significance Single submitter
- NEK3 p.Arg245His Uncertain significance Single submitter
- NEK3 p.Asn138Ser Uncertain significance Single submitter
- NEK3 p.Asn241Ser Uncertain significance Single submitter
- NEK3 p.Asn304Asp Uncertain significance Single submitter
- NEK3 p.Asn329Lys Uncertain significance Single submitter
- NEK3 p.Asn357Asp Uncertain significance Single submitter
- NEK3 p.Asn369Asp Uncertain significance Single submitter
- NEK3 p.Cys82Tyr Uncertain significance Single submitter
- NEK3 p.Gln137Arg Uncertain significance Single submitter
- NEK3 p.Gln94Arg Uncertain significance Single submitter
- NEK3 p.Glu268Lys Uncertain significance Single submitter
- NEK3 p.Glu311Asp Uncertain significance Single submitter
- NEK3 p.Glu70Ala Uncertain significance Single submitter
- NEK3 p.Glu80Val Uncertain significance Single submitter
- NEK3 p.Gly217Ala Uncertain significance Single submitter
- NEK3 p.His286Asp Uncertain significance Single submitter
- NEK3 p.His286Pro Uncertain significance Single submitter
-
NEK3 p.Ile10Asn
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- NEK3 p.Ile128Thr Uncertain significance Single submitter
- NEK3 p.Ile128Val Uncertain significance Single submitter
- NEK3 p.Ile269Met Uncertain significance Single submitter
- NEK3 p.Ile281Leu Uncertain significance Single submitter
- NEK3 p.Leu53Ile Uncertain significance Single submitter
- NEK3 p.Lys129Glu Uncertain significance Single submitter
- NEK3 p.Lys33Glu Uncertain significance Single submitter
- NEK3 p.Lys343Glu Uncertain significance Single submitter
- NEK3 p.Lys346Gln Uncertain significance Single submitter
- NEK3 p.Lys365Gln Uncertain significance Single submitter
- NEK3 p.Lys97Asn Uncertain significance Single submitter
- NEK3 p.Met111Val Uncertain significance Single submitter
- NEK3 p.Met156Thr Uncertain significance Single submitter
- NEK3 p.Met271Leu Uncertain significance Single submitter
- NEK3 p.Met88Ile Uncertain significance Single submitter
- NEK3 p.Met9Ile Uncertain significance Single submitter
- NEK3 p.Pro171Ala Uncertain significance Single submitter
- NEK3 p.Pro436Ser Uncertain significance Single submitter
- NEK3 p.Ser14Pro Uncertain significance Single submitter
- NEK3 p.Ser383Tyr Uncertain significance Single submitter
- NEK3 p.Thr250Met Uncertain significance Single submitter
- NEK3 p.Tyr162Cys Uncertain significance Single submitter
- NEK3 p.Tyr167Cys Uncertain significance Single submitter
- NEK3 p.Tyr179His Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- NEK3 p.Arg150Cys Uncertain significance Single submitter
- NEK3 p.Arg150His Uncertain significance Single submitter
- NEK3 p.Arg259Trp Uncertain significance Single submitter
- NEK3 p.Gln22Pro Uncertain significance Single submitter
- NEK3 p.Gly255Val Uncertain significance Single submitter
- NEK3 p.His59Gln Uncertain significance Single submitter
- NEK3 p.Ile104Met Uncertain significance Single submitter
- NEK3 p.Ile10Thr Uncertain significance Single submitter
- NEK3 p.Leu372Pro Uncertain significance Single submitter
- NEK3 p.Met79Ile Uncertain significance Single submitter
- NEK3 p.Phe99Leu Uncertain significance Single submitter
- NEK3 p.Pro201Thr Uncertain significance Single submitter
- NEK3 p.Pro223Leu Uncertain significance Single submitter
- NEK3 p.Tyr4Cys Uncertain significance Single submitter
All NEK3 variants
Benign 2
- p.Arg259Gly Multiple submitters
- p.Thr293fs Single submitter
Likely benign 5
- p.Gly444= Single submitter
- p.Gly473Arg Single submitter
- p.His23Gln Single submitter
- p.Met103Thr Single submitter
- p.Val257Leu Single submitter
Uncertain significance 68
- p.Ala204Val Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala55Val Single submitter
- p.Ala71Gly Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Asn138Ser Single submitter ⚠
- p.Asn241Ser Single submitter ⚠
- p.Asn304Asp Single submitter ⚠
- p.Asn329Lys Single submitter ⚠
- p.Asn357Asp Single submitter ⚠
- p.Asn369Asp Single submitter ⚠
- p.Cys82Tyr Single submitter ⚠
- p.Gln137Arg Single submitter ⚠
- p.Gln22Pro Single submitter ⚠
- p.Gln94Arg Single submitter ⚠
- p.Glu268Lys Single submitter ⚠
- p.Glu311Asp Single submitter ⚠
- p.Glu70Ala Single submitter ⚠
- p.Glu80Val Single submitter ⚠
- p.Gly217Ala Single submitter ⚠
- p.Gly255Val Single submitter ⚠
- p.His286Asp Single submitter ⚠
- p.His286Pro Single submitter ⚠
- p.His59Gln Single submitter ⚠
- p.Ile104Met Single submitter ⚠
- p.Ile10Asn Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Ile10Thr Single submitter ⚠
- p.Ile128Thr Single submitter ⚠
- p.Ile128Val Single submitter ⚠
- p.Ile269Met Single submitter ⚠
- p.Ile281Leu Single submitter ⚠
- p.Ile62Met Single submitter
- p.Leu152Ile Single submitter
- p.Leu372Pro Single submitter ⚠
- p.Leu53Ile Single submitter ⚠
- p.Lys129Glu Single submitter ⚠
- p.Lys33Glu Single submitter ⚠
- p.Lys343Glu Single submitter ⚠
- p.Lys346Gln Single submitter ⚠
- p.Lys365Gln Single submitter ⚠
- p.Lys97Asn Single submitter ⚠
- p.Met111Val Single submitter ⚠
- p.Met156Thr Single submitter ⚠
- p.Met271Leu Single submitter ⚠
- p.Met79Ile Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Met9Ile Single submitter ⚠
- p.Phe99Leu Single submitter ⚠
- p.Pro171Ala Single submitter ⚠
- p.Pro178Leu Single submitter
- p.Pro201Thr Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro436Ser Single submitter ⚠
- p.Pro445Ser Single submitter
- p.Ser14Pro Single submitter ⚠
- p.Ser247Leu Single submitter
- p.Ser383Tyr Single submitter ⚠
- p.Thr136Ile Single submitter
- p.Thr250Met Single submitter ⚠
- p.Tyr162Cys Single submitter ⚠
- p.Tyr167Cys Single submitter ⚠
- p.Tyr179His Single submitter ⚠
- p.Tyr4Cys Single submitter ⚠
- p.Val78Ala Single submitter