NEK4 — 116 ClinVar variants
All ClinVar germline NEK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
1 Likely pathogenic · 13 Likely benign · 102 Uncertain significance
Full NEK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK4 p.Ala271Gly Uncertain significance Single submitter
- NEK4 p.Ala730Val Uncertain significance Single submitter
- NEK4 p.Arg10Gln Uncertain significance Single submitter
- NEK4 p.Arg26Gln Uncertain significance Single submitter
- NEK4 p.Arg47Trp Uncertain significance Single submitter
- NEK4 p.Arg534Gln Uncertain significance Single submitter
- NEK4 p.Arg534Leu Uncertain significance Single submitter
- NEK4 p.Arg537Trp Uncertain significance Single submitter
- NEK4 p.Arg590His Uncertain significance Single submitter
- NEK4 p.Arg636Ser Uncertain significance Single submitter
- NEK4 p.Arg743Gln Uncertain significance Single submitter
- NEK4 p.Arg788Cys Uncertain significance Single submitter
- NEK4 p.Arg93Gln Uncertain significance Single submitter
- NEK4 p.Asn207Ser Uncertain significance Single submitter
- NEK4 p.Asp188Glu Uncertain significance Single submitter
- NEK4 p.Asp188Val Uncertain significance Single submitter
- NEK4 p.Asp610His Uncertain significance Single submitter
- NEK4 p.Asp652Glu Uncertain significance Single submitter
- NEK4 p.Asp689Glu Uncertain significance Single submitter
- NEK4 p.Asp694Gly Uncertain significance Single submitter
- NEK4 p.Asp809Val Uncertain significance Single submitter
- NEK4 p.Cys401Arg Uncertain significance Single submitter
- NEK4 p.Cys675Tyr Uncertain significance Single submitter
- NEK4 p.Gln309His Uncertain significance Single submitter
- NEK4 p.Gln445Arg Uncertain significance Single submitter
- NEK4 p.Gln456Arg Uncertain significance Single submitter
- NEK4 p.Gln456Glu Uncertain significance Single submitter
- NEK4 p.Gln538Arg Uncertain significance Single submitter
- NEK4 p.Gln583Arg Uncertain significance Single submitter
- NEK4 p.Gln653His Uncertain significance Single submitter
- NEK4 p.Gln98Arg Uncertain significance Single submitter
- NEK4 p.Glu51Gln Uncertain significance Single submitter
- NEK4 p.Glu704Gly Uncertain significance Single submitter
- NEK4 p.Gly151Arg Uncertain significance Single submitter
- NEK4 p.Gly221Glu Uncertain significance Single submitter
- NEK4 p.Gly399Arg Uncertain significance Single submitter
- NEK4 p.Gly644Arg Uncertain significance Single submitter
- NEK4 p.Gly88Glu Uncertain significance Single submitter
- NEK4 p.His126Asn Uncertain significance Single submitter
- NEK4 p.His129Arg Uncertain significance Single submitter
- NEK4 p.His159Leu Uncertain significance Single submitter
- NEK4 p.His25Tyr Uncertain significance Single submitter
- NEK4 p.His546Arg Uncertain significance Single submitter
- NEK4 p.Ile115Val Uncertain significance Single submitter
- NEK4 p.Ile145Val Uncertain significance Single submitter
- NEK4 p.Ile34Val Uncertain significance Single submitter
- NEK4 p.Ile367Val Uncertain significance Single submitter
- NEK4 p.Ile369Val Uncertain significance Single submitter
- NEK4 p.Ile511Thr Uncertain significance Single submitter
- NEK4 p.Ile511Val Uncertain significance Single submitter
- NEK4 p.Ile768Val Uncertain significance Single submitter
- NEK4 p.Leu234Pro Uncertain significance Single submitter
- NEK4 p.Leu269Ser Uncertain significance Single submitter
- NEK4 p.Leu311Phe Uncertain significance Single submitter
- NEK4 p.Leu613Ser Uncertain significance Single submitter
- NEK4 p.Lys146Glu Uncertain significance Single submitter
- NEK4 p.Lys513Glu Uncertain significance Single submitter
- NEK4 p.Lys717Arg Uncertain significance Single submitter
- NEK4 p.Phe267Val Uncertain significance Single submitter
- NEK4 p.Pro371Ser Uncertain significance Single submitter
- NEK4 p.Pro421Leu Uncertain significance Single submitter
- NEK4 p.Pro523Leu Uncertain significance Single submitter
- NEK4 p.Ser164Gly Uncertain significance Single submitter
- NEK4 p.Ser179Leu Uncertain significance Single submitter
- NEK4 p.Ser316Phe Uncertain significance Single submitter
- NEK4 p.Ser343Asn Uncertain significance Single submitter
- NEK4 p.Ser402Thr Uncertain significance Single submitter
- NEK4 p.Ser570Tyr Uncertain significance Single submitter
- NEK4 p.Ser596Phe Uncertain significance Single submitter
- NEK4 p.Ser629Thr Uncertain significance Single submitter
- NEK4 p.Ser682Thr Uncertain significance Single submitter
- NEK4 p.Ser826Thr Uncertain significance Single submitter
- NEK4 p.Thr240Ala Uncertain significance Single submitter
- NEK4 p.Thr240Pro Uncertain significance Single submitter
- NEK4 p.Thr544Ser Uncertain significance Single submitter
- NEK4 p.Thr67Ala Uncertain significance Single submitter
- NEK4 p.Thr702Arg Uncertain significance Single submitter
- NEK4 p.Tyr6His Uncertain significance Single submitter
- NEK4 p.Val365Ile Uncertain significance Single submitter
- NEK4 p.Val378Met Uncertain significance Single submitter
- NEK4 p.Val709Ile Uncertain significance Single submitter
- NEK4 p.Val727Ile Uncertain significance Single submitter
- NEK4 p.Val733Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- NEK4 p.Ala116Val Uncertain significance Single submitter
- NEK4 p.Arg263Trp Uncertain significance Single submitter
- NEK4 p.Arg611Gly Uncertain significance Single submitter
- NEK4 p.Arg620Gln Uncertain significance Single submitter
- NEK4 p.Asn180Lys Uncertain significance Single submitter
- NEK4 p.Asp210Asn Uncertain significance Single submitter
- NEK4 p.Gly750Glu Uncertain significance Single submitter
- NEK4 p.Leu711Trp Uncertain significance Single submitter
- NEK4 p.Met211Ile Uncertain significance Single submitter
- NEK4 p.Ser174Cys Uncertain significance Single submitter
- NEK4 p.Thr685Ile Uncertain significance Single submitter
- NEK4 p.Val113Ala Uncertain significance Single submitter
All NEK4 variants
Likely pathogenic 1
- p.Ile673fs No assertion criteria ciliopathy
Likely benign 13
- p.Arg590Cys Single submitter
- p.Arg590Ser Single submitter
- p.Arg658Gln Single submitter
- p.Arg659Trp Single submitter
- p.Arg788His Single submitter
- p.Arg813His Single submitter
- p.Arg815Gln Single submitter
- p.Asn525Ser Single submitter
- p.Asp520Gly Single submitter
- p.Leu795= Single submitter
- p.Met427Thr Single submitter
- p.Met605Ile Single submitter
- p.Lys463Arg No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 102
- p.Ala116Val Single submitter ⚠
- p.Ala271Gly Single submitter ⚠
- p.Ala730Val Single submitter ⚠
- p.Arg10Gln Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg47Trp Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg534Leu Single submitter ⚠
- p.Arg537Trp Single submitter ⚠
- p.Arg590His Single submitter ⚠
- p.Arg611Gly Single submitter ⚠
- p.Arg620Gln Single submitter ⚠
- p.Arg636Ser Single submitter ⚠
- p.Arg740Trp Single submitter
- p.Arg743Gln Single submitter ⚠
- p.Arg788Cys Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn180Lys Single submitter ⚠
- p.Asn207Ser Single submitter ⚠
- p.Asp188Glu Single submitter ⚠
- p.Asp188Val Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp610His Single submitter ⚠
- p.Asp652Glu Single submitter ⚠
- p.Asp689Glu Single submitter ⚠
- p.Asp694Gly Single submitter ⚠
- p.Asp785Glu Single submitter
- p.Asp809Val Single submitter ⚠
- p.Cys401Arg Single submitter ⚠
- p.Cys675Tyr Single submitter ⚠
- p.Gln309His Single submitter ⚠
- p.Gln445Arg Single submitter ⚠
- p.Gln456Arg Single submitter ⚠
- p.Gln456Glu Single submitter ⚠
- p.Gln538Arg Single submitter ⚠
- p.Gln583Arg Single submitter ⚠
- p.Gln653His Single submitter ⚠
- p.Gln98Arg Single submitter ⚠
- p.Glu19Ala Single submitter
- p.Glu51Gln Single submitter ⚠
- p.Glu704Gly Single submitter ⚠
- p.Gly151Arg Single submitter ⚠
- p.Gly221Glu Single submitter ⚠
- p.Gly399Arg Single submitter ⚠
- p.Gly644Arg Single submitter ⚠
- p.Gly750Glu Single submitter ⚠
- p.Gly88Glu Single submitter ⚠
- p.His126Asn Single submitter ⚠
- p.His129Arg Single submitter ⚠
- p.His159Leu Single submitter ⚠
- p.His25Tyr Single submitter ⚠
- p.His546Arg Single submitter ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Ile34Val Single submitter ⚠
- p.Ile362Asn Single submitter
- p.Ile367Val Single submitter ⚠
- p.Ile369Val Single submitter ⚠
- p.Ile511Thr Single submitter ⚠
- p.Ile511Val Single submitter ⚠
- p.Ile768Val Single submitter ⚠
- p.Leu234Pro Single submitter ⚠
- p.Leu269Ser Single submitter ⚠
- p.Leu311Phe Single submitter ⚠
- p.Leu613Ser Single submitter ⚠
- p.Leu711Trp Single submitter ⚠
- p.Leu718Pro Single submitter
- p.Lys146Glu Single submitter ⚠
- p.Lys513Glu Single submitter ⚠
- p.Lys717Arg Single submitter ⚠
- p.Lys737Ile Single submitter
- p.Met211Ile Single submitter ⚠
- p.Phe267Val Single submitter ⚠
- p.Pro371Ser Single submitter ⚠
- p.Pro421Leu Single submitter ⚠
- p.Pro523Leu Single submitter ⚠
- p.Ser164Gly Single submitter ⚠
- p.Ser174Cys Single submitter ⚠
- p.Ser179Leu Single submitter ⚠
- p.Ser316Phe Single submitter ⚠
- p.Ser343Asn Single submitter ⚠
- p.Ser402Thr Single submitter ⚠
- p.Ser570Tyr Single submitter ⚠
- p.Ser596Phe Single submitter ⚠
- p.Ser629Thr Single submitter ⚠
- p.Ser682Thr Single submitter ⚠
- p.Ser826Thr Single submitter ⚠
- p.Thr240Ala Single submitter ⚠
- p.Thr240Pro Single submitter ⚠
- p.Thr544Ser Single submitter ⚠
- p.Thr67Ala Single submitter ⚠
- p.Thr685Ile Single submitter ⚠
- p.Thr702Arg Single submitter ⚠
- p.Tyr6His Single submitter ⚠
- p.Tyr80Cys Single submitter
- p.Val113Ala Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val378Met Single submitter ⚠
- p.Val709Ile Single submitter ⚠
- p.Val727Ile Single submitter ⚠
- p.Val733Leu Single submitter ⚠