NEK6 — 45 ClinVar variants
All ClinVar germline NEK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 3 Likely benign · 41 Uncertain significance
Full NEK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK6 p.Ala159Thr Uncertain significance Single submitter
- NEK6 p.Ala43Val Uncertain significance Single submitter
- NEK6 p.Asn16Lys Uncertain significance Single submitter
- NEK6 p.Gln4Arg Uncertain significance Single submitter
- NEK6 p.Glu239Lys Uncertain significance Single submitter
- NEK6 p.Glu276Lys Uncertain significance Single submitter
- NEK6 p.Glu58Lys Uncertain significance Single submitter
- NEK6 p.Gly189Ser Uncertain significance Single submitter
- NEK6 p.Gly22Trp Uncertain significance Single submitter
- NEK6 p.Gly271Arg Uncertain significance Single submitter
- NEK6 p.His10Arg Uncertain significance Single submitter
- NEK6 p.His291Arg Uncertain significance Single submitter
- NEK6 p.His300Arg Uncertain significance Single submitter
- NEK6 p.His307Arg Uncertain significance Single submitter
- NEK6 p.His307Tyr Uncertain significance Single submitter
- NEK6 p.Ile106Val Uncertain significance Single submitter
- NEK6 p.Leu100Arg Uncertain significance Single submitter
- NEK6 p.Met252Ile Uncertain significance Single submitter
- NEK6 p.Met284Thr Uncertain significance Single submitter
- NEK6 p.Pro145Leu Uncertain significance Single submitter
- NEK6 p.Ser13Cys Uncertain significance Single submitter
- NEK6 p.Thr35Met Uncertain significance Single submitter
- NEK6 p.Tyr136His Uncertain significance Single submitter
- NEK6 p.Val160Met Uncertain significance Single submitter
- NEK6 p.Val178Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NEK6 variants
Benign 1
- p.Cys90= Single submitter
Likely benign 3
- p.Gly6Ser Single submitter
- p.Ser14Pro Single submitter
- p.Thr35Ala Single submitter
Uncertain significance 41
- c.-26G>A Single submitter
- c.-29-8925G>A Single submitter
- c.-29-8925G>T Single submitter
- c.-29-8957C>G Single submitter
- c.-29-8971G>A Single submitter
- c.-29-8974T>A Single submitter
- c.-29-8986A>G Single submitter
- c.-29-8992C>T Single submitter
- p.Ala159Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Asn16Lys Single submitter ⚠
- p.Gln4Arg Single submitter ⚠
- p.Glu239Lys Single submitter ⚠
- p.Glu276Lys Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Gly189Ser Single submitter ⚠
- p.Gly22Trp Single submitter ⚠
- p.Gly271Arg Single submitter ⚠
- p.His10Arg Single submitter ⚠
- p.His291Arg Single submitter ⚠
- p.His300Arg Single submitter ⚠
- p.His307Arg Single submitter ⚠
- p.His307Tyr Single submitter ⚠
- p.Ile106Val Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Ile230Met Single submitter ⚠
- p.Ile94Met Single submitter
- p.Leu100Arg Single submitter ⚠
- p.Met252Ile Single submitter ⚠
- p.Met284Thr Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro268Arg Single submitter ⚠
- p.Ser13Cys Single submitter ⚠
- p.Ser232Ala Single submitter
- p.Thr35Met Single submitter ⚠
- p.Tyr136His Single submitter ⚠
- p.Val160Met Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val299Met Single submitter