NEK7 — 22 ClinVar variants
All ClinVar germline NEK7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
22 Uncertain significance
Full NEK7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEK7 p.Ala21Ser Uncertain significance Single submitter
- NEK7 p.Asn108His Uncertain significance Single submitter
- NEK7 p.Asn90Ser Uncertain significance Single submitter
- NEK7 p.Gln19Arg Uncertain significance Single submitter
- NEK7 p.Gly7Arg Uncertain significance Single submitter
- NEK7 p.His262Gln Uncertain significance Single submitter
- NEK7 p.Met152Arg Uncertain significance Single submitter
- NEK7 p.Met152Thr Uncertain significance Single submitter
- NEK7 p.Pro59Gln Uncertain significance Single submitter
- NEK7 p.Ser147Gly Uncertain significance Single submitter
- NEK7 p.Ser46Asn Uncertain significance Single submitter
- NEK7 p.Tyr263Cys Uncertain significance Single submitter
- NEK7 p.Val143Ala Uncertain significance Single submitter
- NEK7 p.Val167Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- NEK7 p.Asn105Lys Uncertain significance Single submitter
- NEK7 p.Asp104His Uncertain significance Single submitter
- NEK7 p.Asp278Val Uncertain significance Single submitter
- NEK7 p.Asp284Gly Uncertain significance Single submitter
- NEK7 p.Gly57Arg Uncertain significance Single submitter
- NEK7 p.Met158Leu Uncertain significance Single submitter
- NEK7 p.Val65Met Uncertain significance Single submitter
All NEK7 variants
Uncertain significance 22
- p.Ala21Ser Single submitter ⚠
- p.Arg42Cys Single submitter
- p.Asn105Lys Single submitter ⚠
- p.Asn108His Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp104His Single submitter ⚠
- p.Asp278Val Single submitter ⚠
- p.Asp284Gly Single submitter ⚠
- p.Gln19Arg Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.His262Gln Single submitter ⚠
- p.Met152Arg Single submitter ⚠
- p.Met152Thr Single submitter ⚠
- p.Met158Leu Single submitter ⚠
- p.Pro59Gln Single submitter ⚠
- p.Ser147Gly Single submitter ⚠
- p.Ser46Asn Single submitter ⚠
- p.Tyr263Cys Single submitter ⚠
- p.Val143Ala Single submitter ⚠
- p.Val167Met Single submitter ⚠
- p.Val65Met Single submitter ⚠