NEU2 — 61 ClinVar variants
All ClinVar germline NEU2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
5 Likely benign · 56 Uncertain significance
Full NEU2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEU2 p.Ala145Glu Uncertain significance Single submitter
- NEU2 p.Ala150Val Uncertain significance Single submitter
- NEU2 p.Ala17Thr Uncertain significance Single submitter
- NEU2 p.Ala333Thr Uncertain significance Single submitter
- NEU2 p.Ala38Val Uncertain significance Single submitter
- NEU2 p.Ala61Thr Uncertain significance Single submitter
- NEU2 p.Ala93Val Uncertain significance Single submitter
- NEU2 p.Arg152Trp Uncertain significance Single submitter
- NEU2 p.Arg182Trp Uncertain significance Single submitter
- NEU2 p.Arg21Lys Uncertain significance Single submitter
- NEU2 p.Arg230Lys Uncertain significance Single submitter
- NEU2 p.Arg283Cys Uncertain significance Single submitter
- NEU2 p.Arg283Gly Uncertain significance Single submitter
- NEU2 p.Arg283Leu Uncertain significance Single submitter
- NEU2 p.Arg304Thr Uncertain significance Single submitter
- NEU2 p.Arg41Trp Uncertain significance Single submitter
- NEU2 p.Arg56Lys Uncertain significance Single submitter
- NEU2 p.Arg83Gln Uncertain significance Single submitter
- NEU2 p.Asn250Ser Uncertain significance Single submitter
- NEU2 p.Asp345Val Uncertain significance Single submitter
- NEU2 p.Gln113Arg Uncertain significance Single submitter
- NEU2 p.Gln31Glu Uncertain significance Single submitter
- NEU2 p.Gln40Glu Uncertain significance Single submitter
- NEU2 p.Glu360Lys Uncertain significance Single submitter
- NEU2 p.Gly227Arg Uncertain significance Single submitter
- NEU2 p.Gly330Cys Uncertain significance Single submitter
- NEU2 p.Gly57Glu Uncertain significance Single submitter
- NEU2 p.His185Gln Uncertain significance Single submitter
- NEU2 p.Ile52Thr Uncertain significance Single submitter
- NEU2 p.Leu240Arg Uncertain significance Single submitter
- NEU2 p.Leu337Phe Uncertain significance Single submitter
- NEU2 p.Phe102Val Uncertain significance Single submitter
- NEU2 p.Pro282Leu Uncertain significance Single submitter
- NEU2 p.Pro62Ala Uncertain significance Single submitter
- NEU2 p.Ser173Cys Uncertain significance Single submitter
- NEU2 p.Ser199Gly Uncertain significance Single submitter
- NEU2 p.Ser284Leu Uncertain significance Single submitter
- NEU2 p.Ser288Cys Uncertain significance Single submitter
- NEU2 p.Ser331Ile Uncertain significance Single submitter
- NEU2 p.Thr233Asn Uncertain significance Single submitter
- NEU2 p.Trp154Leu Uncertain significance Single submitter
- NEU2 p.Val265Glu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- NEU2 p.Ala178Thr Uncertain significance Single submitter
- NEU2 p.Ala222Thr Uncertain significance Single submitter
- NEU2 p.Ala375Pro Uncertain significance Single submitter
- NEU2 p.Arg123Trp Uncertain significance Single submitter
- NEU2 p.Arg134Ser Uncertain significance Single submitter
- NEU2 p.Asp345Glu Uncertain significance Single submitter
- NEU2 p.Gln273His Likely benign Single submitter
- NEU2 p.Gly330Ser Uncertain significance Single submitter
- NEU2 p.Thr110Met Uncertain significance Single submitter
- NEU2 p.Thr296Ala Uncertain significance Single submitter
- NEU2 p.Thr95Met Uncertain significance Single submitter
All NEU2 variants
Likely benign 5
- p.Arg172Gln Single submitter
- p.Arg204His Single submitter
- p.Asp169Asn Single submitter
- p.Asp306Asn Single submitter
- p.Gln273His Single submitter ⚠
Uncertain significance 56
- p.Ala145Glu Single submitter ⚠
- p.Ala150Val Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala375Pro Single submitter ⚠
- p.Ala38Val Single submitter ⚠
- p.Ala61Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg123Trp Single submitter ⚠
- p.Arg134Ser Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg21Lys Single submitter ⚠
- p.Arg230Lys Single submitter ⚠
- p.Arg283Cys Single submitter ⚠
- p.Arg283Gly Single submitter ⚠
- p.Arg283Leu Single submitter ⚠
- p.Arg304Thr Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg56Lys Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Asn250Ser Single submitter ⚠
- p.Asp345Glu Single submitter ⚠
- p.Asp345Val Single submitter ⚠
- p.Gln113Arg Single submitter ⚠
- p.Gln31Glu Single submitter ⚠
- p.Gln40Glu Single submitter ⚠
- p.Glu360Lys Single submitter ⚠
- p.Glu47Gly Single submitter
- p.Gly227Arg Single submitter ⚠
- p.Gly330Cys Single submitter ⚠
- p.Gly330Ser Single submitter ⚠
- p.Gly57Glu Single submitter ⚠
- p.His185Gln Single submitter ⚠
- p.Ile52Thr Single submitter ⚠
- p.Leu240Arg Single submitter ⚠
- p.Leu253Pro Single submitter
- p.Leu337Phe Single submitter ⚠
- p.Phe102Val Single submitter ⚠
- p.Pro282Leu Single submitter ⚠
- p.Pro62Ala Single submitter ⚠
- p.Ser173Cys Single submitter ⚠
- p.Ser199Gly Single submitter ⚠
- p.Ser284Leu Single submitter ⚠
- p.Ser288Cys Single submitter ⚠
- p.Ser331Ile Single submitter ⚠
- p.Thr110Met Single submitter ⚠
- p.Thr122Met Single submitter
- p.Thr233Asn Single submitter ⚠
- p.Thr296Ala Single submitter ⚠
- p.Thr95Met Single submitter ⚠
- p.Trp154Leu Single submitter ⚠
- p.Val244Gly Single submitter
- p.Val265Glu Single submitter ⚠