NFRKB — 172 ClinVar variants

All ClinVar germline NFRKB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 155 flagged for review →

1 Conflicting · 9 Likely benign · 162 Uncertain significance

Full NFRKB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 155

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

NFRKB p.Thr863Met Conflicting Single submitter

Predictors lean, ClinVar uncertain 130

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All NFRKB variants

Conflicting classifications of pathogenicity 1

p.Thr863Met Single submitter ⚠

Likely benign 9

p.Ala742Ser Single submitter
p.Ala860= Single submitter
p.Asn137Ser Single submitter
p.Asn285Ser Single submitter
p.Pro817Thr Single submitter
p.Ser1116= Single submitter
p.Ser700Gly Single submitter
p.Val343Ile Single submitter
p.Val504= Single submitter

Uncertain significance 162

p.Arg792Gln Multiple submitters ⚠
c.641-27A>C Single submitter
p.Ala1057Thr Single submitter ⚠
p.Ala1118Val Single submitter ⚠
p.Ala1128Val Single submitter ⚠
p.Ala1148Pro Single submitter ⚠
p.Ala1159Ser Single submitter ⚠
p.Ala230Val Single submitter ⚠
p.Ala247Thr Single submitter ⚠
p.Ala293Val Single submitter ⚠
p.Ala334Asp Single submitter ⚠
p.Ala349Asp Single submitter ⚠
p.Ala357Thr Single submitter ⚠
p.Ala575Ser Single submitter ⚠
p.Ala670Thr Single submitter ⚠
p.Ala742Val Single submitter ⚠
p.Ala755Pro Single submitter ⚠
p.Ala791Ser Single submitter ⚠
p.Ala791Thr Single submitter ⚠
p.Ala815Pro Single submitter ⚠
p.Arg124Trp Single submitter ⚠
p.Arg1260His Single submitter ⚠
p.Arg145Trp Single submitter ⚠
p.Arg162Gln Single submitter ⚠
p.Arg174Cys Single submitter ⚠
p.Arg179Cys Single submitter ⚠
p.Arg179His Single submitter ⚠
p.Arg184Trp Single submitter ⚠
p.Arg187Gln Single submitter ⚠
p.Arg225Cys Single submitter ⚠
p.Arg234Trp Single submitter ⚠
p.Arg24His Single submitter ⚠
p.Arg35Ser Single submitter ⚠
p.Arg526Cys Single submitter ⚠
p.Arg539Cys Single submitter ⚠
p.Arg539His Single submitter ⚠
p.Arg570Cys Single submitter
p.Arg584Pro Single submitter ⚠
p.Arg597Trp Single submitter ⚠
p.Arg652Cys Single submitter ⚠
p.Arg67His Single submitter ⚠
p.Arg792Leu Single submitter ⚠
p.Arg806Gln Single submitter ⚠
p.Arg946His Single submitter ⚠
p.Asn1209Ser Single submitter ⚠
p.Asn137Thr Single submitter ⚠
p.Asn292Asp Single submitter ⚠
p.Asn373Asp Single submitter ⚠
p.Asn373Ser Single submitter ⚠
p.Asn97Ser Single submitter ⚠
p.Asp1021Asn Single submitter ⚠
p.Asp572Asn Single submitter ⚠
p.Cys487Ser Single submitter ⚠
p.Gln140Arg Single submitter ⚠
p.Gln463Lys Single submitter ⚠
p.Gln705His Single submitter ⚠
p.Gln788Lys Single submitter ⚠
p.Gln819Arg Single submitter ⚠
p.Glu185Asp Single submitter ⚠
p.Glu266Lys Single submitter ⚠
p.Glu335Lys Single submitter ⚠
p.Glu450Val Single submitter ⚠
p.Gly1073Arg Single submitter ⚠
p.Gly165Val Single submitter ⚠
p.Gly515Ala Single submitter ⚠
p.Gly747Ala Single submitter ⚠
p.Gly801Arg Single submitter ⚠
p.Gly873Glu Single submitter ⚠
p.His1011Gln Single submitter ⚠
p.His265Asp Single submitter ⚠
p.His270Arg Single submitter ⚠
p.His274Gln Single submitter ⚠
p.Ile106Val Single submitter ⚠
p.Ile1105Val Single submitter ⚠
p.Ile1221Val Single submitter
p.Ile287Val Single submitter ⚠
p.Ile323Met Single submitter ⚠
p.Ile386Met Single submitter ⚠
p.Ile735Val Single submitter ⚠
p.Ile947Val Single submitter ⚠
p.Ile960Val Single submitter ⚠
p.Leu1210Phe Single submitter ⚠
p.Leu1269Pro Single submitter
p.Leu14Phe Single submitter ⚠
p.Leu261Phe Single submitter ⚠
p.Leu370Ile Single submitter ⚠
p.Leu4Ser Single submitter ⚠
p.Leu55Arg Single submitter ⚠
p.Leu802Pro Single submitter ⚠
p.Leu8Pro Single submitter ⚠
p.Leu90Ser Single submitter ⚠
p.Lys1004Arg Single submitter ⚠
p.Lys1025Glu Single submitter ⚠
p.Lys1043Arg Single submitter ⚠
p.Lys1074Arg Single submitter ⚠
p.Lys249Glu Single submitter ⚠
p.Lys258Glu Single submitter ⚠
p.Lys310Ile Single submitter ⚠
p.Lys459Glu Single submitter ⚠
p.Lys982Asn Single submitter ⚠
p.Met1195Leu Single submitter ⚠
p.Met1Val Single submitter
p.Met715Ile Single submitter ⚠
p.Met775Val Single submitter ⚠
p.Met976Val Single submitter ⚠
p.Phe111Val Single submitter ⚠
p.Phe448Leu Single submitter ⚠
p.Pro1032Leu Single submitter ⚠
p.Pro1046Leu Single submitter ⚠
p.Pro1099Ser Single submitter ⚠
p.Pro1160Arg Single submitter ⚠
p.Pro1238Ser Single submitter ⚠
p.Pro1296Leu Single submitter ⚠
p.Pro166Ser Single submitter ⚠
p.Pro16Leu Single submitter ⚠
p.Pro275Leu Single submitter
p.Pro336Leu Single submitter ⚠
p.Pro500Ala Single submitter ⚠
p.Pro500Ser Single submitter ⚠
p.Pro502Ser Single submitter
p.Pro702Ser Single submitter ⚠
p.Pro717His Single submitter ⚠
p.Pro725Ser Single submitter ⚠
p.Pro739Leu Single submitter ⚠
p.Pro748Ser Single submitter ⚠
p.Pro754Ala Single submitter ⚠
p.Pro823Leu Single submitter ⚠
p.Pro888Leu Single submitter ⚠
p.Pro957Ser Single submitter ⚠
p.Pro974Leu Single submitter ⚠
p.Ser1116Leu Single submitter ⚠
p.Ser1275Cys Single submitter ⚠
p.Ser138Ala Single submitter ⚠
p.Ser155Arg Single submitter ⚠
p.Ser164Arg Single submitter ⚠
p.Ser376Thr Single submitter ⚠
p.Ser736Phe Single submitter ⚠
p.Ser759Leu Single submitter ⚠
p.Ser787Tyr Single submitter ⚠
p.Ser797Pro Single submitter ⚠
p.Ser820Leu Single submitter ⚠
p.Thr1104Ala Single submitter ⚠
p.Thr1123Asn Single submitter ⚠
p.Thr1174Met Single submitter ⚠
p.Thr1225Pro Single submitter ⚠
p.Thr238Ile Single submitter ⚠
p.Thr23Met Single submitter ⚠
p.Thr455Ile Single submitter ⚠
p.Thr514Met Single submitter
p.Thr750Ala Single submitter ⚠
p.Thr851Ala Single submitter ⚠
p.Thr894Met Single submitter ⚠
p.Thr906Met Single submitter ⚠
p.Val1162Met Single submitter ⚠
p.Val1190Leu Single submitter ⚠
p.Val1200Met Single submitter ⚠
p.Val236Met Single submitter ⚠
p.Val623Met Single submitter ⚠
p.Val723Ile Single submitter ⚠
p.Val794Leu Single submitter ⚠
p.Val794Met Single submitter ⚠
p.Val858Ile Single submitter ⚠