NGFR — 78 ClinVar variants
All ClinVar germline NGFR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
6 Benign · 1 Benign/Likely benign · 4 Likely benign · 67 Uncertain significance
Full NGFR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NGFR p.Ala110Ser Uncertain significance Single submitter
- NGFR p.Ala229Val Uncertain significance Single submitter
- NGFR p.Ala380Asp Uncertain significance Single submitter
- NGFR p.Ala385Thr Uncertain significance Single submitter
- NGFR p.Ala400Thr Uncertain significance Single submitter
- NGFR p.Arg198Gln Uncertain significance Single submitter
- NGFR p.Arg198Trp Uncertain significance Single submitter
- NGFR p.Arg245Gln Uncertain significance Single submitter
- NGFR p.Arg288Trp Uncertain significance Single submitter
- NGFR p.Arg384His Uncertain significance Single submitter
- NGFR p.Arg406Cys Uncertain significance Single submitter
- NGFR p.Arg406His Uncertain significance Single submitter
- NGFR p.Asn60Ser Uncertain significance Single submitter
- NGFR p.Asp116Glu Uncertain significance Single submitter
- NGFR p.Asp151Glu Uncertain significance Single submitter
- NGFR p.Asp249Asn Uncertain significance Single submitter
- NGFR p.Asp399Glu Uncertain significance Single submitter
- NGFR p.Cys149Ser Uncertain significance Single submitter
- NGFR p.Gln176Arg Uncertain significance Single submitter
- NGFR p.Glu129Lys Uncertain significance Single submitter
- NGFR p.Glu189Gln Uncertain significance Single submitter
- NGFR p.Gly246Ala Uncertain significance Single submitter
- NGFR p.Gly27Cys Uncertain significance Single submitter
- NGFR p.Gly331Ser Uncertain significance Single submitter
- NGFR p.Gly353Ser Uncertain significance Single submitter
- NGFR p.Gly367Cys Uncertain significance Single submitter
- NGFR p.Gly41Ser Uncertain significance Single submitter
- NGFR p.His160Tyr Uncertain significance Single submitter
- NGFR p.Leu251Pro Uncertain significance Single submitter
- NGFR p.Lys330Arg Uncertain significance Single submitter
- NGFR p.Pro166Ser Uncertain significance Single submitter
- NGFR p.Pro201Ala Uncertain significance Single submitter
- NGFR p.Pro202Thr Uncertain significance Single submitter
- NGFR p.Pro210Ser Uncertain significance Single submitter
- NGFR p.Pro340Ser Uncertain significance Single submitter
- NGFR p.Ser325Leu Uncertain significance Single submitter
- NGFR p.Ser395Gly Uncertain significance Single submitter
- NGFR p.Ser395Thr Uncertain significance Single submitter
- NGFR p.Ser416Gly Uncertain significance Single submitter
- NGFR p.Thr173Ala Uncertain significance Single submitter
- NGFR p.Thr212Asn Uncertain significance Single submitter
- NGFR p.Thr244Asn Uncertain significance Single submitter
- NGFR p.Thr247Ile Uncertain significance Single submitter
- NGFR p.Tyr336Phe Uncertain significance Single submitter
- NGFR p.Val161Met Uncertain significance Single submitter
- NGFR p.Val23Met Uncertain significance Single submitter
- NGFR p.Val427Met Uncertain significance Single submitter
- NGFR p.Val76Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- NGFR p.Ala28Asp Uncertain significance Single submitter
- NGFR p.Arg108Cys Uncertain significance Single submitter
- NGFR p.Arg178Leu Uncertain significance Single submitter
- NGFR p.Arg274Trp Uncertain significance Single submitter
- NGFR p.Arg410Gln Uncertain significance Single submitter
- NGFR p.Asn276Asp Uncertain significance Single submitter
- NGFR p.Asp185Asn Uncertain significance Single submitter
- NGFR p.Asp357Tyr Uncertain significance Single submitter
- NGFR p.Glu297Gly Uncertain significance Single submitter
- NGFR p.Gly298Arg Uncertain significance Single submitter
- NGFR p.Ile408Thr Uncertain significance Single submitter
- NGFR p.Leu251Phe Uncertain significance Single submitter
- NGFR p.Ser24Tyr Uncertain significance Single submitter
- NGFR p.Val309Met Uncertain significance Single submitter
- NGFR p.Val63Met Uncertain significance Single submitter
All NGFR variants
Benign 6
- c.67-4C>T Multiple submitters
- p.Ser132Leu Multiple submitters
- p.Thr293= Multiple submitters
- p.Tyr111= Multiple submitters
- c.822-10C>G Single submitter
- p.Gly364= Single submitter
Benign/Likely benign 1
- p.Ser395= Multiple submitters
Likely benign 4
- c.568+9G>A Single submitter
- p.Ala363= Single submitter
- p.Pro210= Single submitter
- p.Val106= Single submitter
Uncertain significance 67
- p.Ala110Ser Single submitter ⚠
- p.Ala229Val Single submitter ⚠
- p.Ala28Asp Single submitter ⚠
- p.Ala380Asp Single submitter ⚠
- p.Ala385Thr Single submitter ⚠
- p.Ala400Thr Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg178Leu Single submitter ⚠
- p.Arg182Cys Single submitter
- p.Arg198Gln Single submitter ⚠
- p.Arg198Trp Single submitter ⚠
- p.Arg245Gln Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg288Trp Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg410Gln Single submitter ⚠
- p.Asn276Asp Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Asp116Glu Single submitter ⚠
- p.Asp151Glu Single submitter ⚠
- p.Asp172His Single submitter
- p.Asp185Asn Single submitter ⚠
- p.Asp249Asn Single submitter ⚠
- p.Asp357Tyr Single submitter ⚠
- p.Asp399Glu Single submitter ⚠
- p.Cys149Ser Single submitter ⚠
- p.Gln176Arg Single submitter ⚠
- p.Glu129Lys Single submitter ⚠
- p.Glu189Gln Single submitter ⚠
- p.Glu297Gly Single submitter ⚠
- p.Gly152Asp Single submitter
- p.Gly246Ala Single submitter ⚠
- p.Gly27Cys Single submitter ⚠
- p.Gly298Arg Single submitter ⚠
- p.Gly331Ser Single submitter ⚠
- p.Gly353Ser Single submitter ⚠
- p.Gly367Cys Single submitter ⚠
- p.Gly41Ser Single submitter ⚠
- p.His160Tyr Single submitter ⚠
- p.Ile408Thr Single submitter ⚠
- p.Leu251Phe Single submitter ⚠
- p.Leu251Pro Single submitter ⚠
- p.Lys330Arg Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro201Ala Single submitter ⚠
- p.Pro202Thr Single submitter ⚠
- p.Pro210Ser Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Ser137Cys Single submitter
- p.Ser24Tyr Single submitter ⚠
- p.Ser325Leu Single submitter ⚠
- p.Ser395Gly Single submitter ⚠
- p.Ser395Thr Single submitter ⚠
- p.Ser416Gly Single submitter ⚠
- p.Thr173Ala Single submitter ⚠
- p.Thr212Asn Single submitter ⚠
- p.Thr244Asn Single submitter ⚠
- p.Thr247Ile Single submitter ⚠
- p.Tyr336Phe Single submitter ⚠
- p.Val161Met Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val309Met Single submitter ⚠
- p.Val427Met Single submitter ⚠
- p.Val63Met Single submitter ⚠
- p.Val76Ala Single submitter ⚠