NIM1K — 59 ClinVar variants
All ClinVar germline NIM1K variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Likely benign · 57 Uncertain significance
Full NIM1K gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NIM1K p.Ala237Pro Uncertain significance Single submitter
- NIM1K p.Ala3Thr Uncertain significance Single submitter
- NIM1K p.Arg18Gln Uncertain significance Single submitter
- NIM1K p.Arg18Pro Uncertain significance Single submitter
- NIM1K p.Arg380His Uncertain significance Single submitter
- NIM1K p.Arg421Cys Uncertain significance Single submitter
- NIM1K p.Arg427Ile Uncertain significance Single submitter
- NIM1K p.Arg43Cys Uncertain significance Single submitter
- NIM1K p.Asn190Lys Uncertain significance Single submitter
- NIM1K p.Asn7Ser Uncertain significance Single submitter
- NIM1K p.Asp23Asn Uncertain significance Single submitter
- NIM1K p.Asp317Asn Uncertain significance Single submitter
- NIM1K p.Glu121Gln Uncertain significance Single submitter
- NIM1K p.Glu369Gly Uncertain significance Single submitter
- NIM1K p.Gly154Ala Uncertain significance Single submitter
- NIM1K p.Gly154Val Uncertain significance Single submitter
- NIM1K p.Gly160Val Uncertain significance Single submitter
- NIM1K p.Gly304Ala Uncertain significance Single submitter
- NIM1K p.Gly40Glu Uncertain significance Single submitter
- NIM1K p.Gly9Ser Uncertain significance Single submitter
- NIM1K p.His129Gln Uncertain significance Single submitter
- NIM1K p.His299Arg Uncertain significance Single submitter
- NIM1K p.His343Tyr Uncertain significance Single submitter
- NIM1K p.Ile134Asn Uncertain significance Single submitter
- NIM1K p.Ile176Val Uncertain significance Single submitter
- NIM1K p.Ile319Val Uncertain significance Single submitter
- NIM1K p.Lys113Thr Uncertain significance Single submitter
- NIM1K p.Lys222Arg Uncertain significance Single submitter
- NIM1K p.Met226Ile Uncertain significance Single submitter
- NIM1K p.Met226Val Uncertain significance Single submitter
- NIM1K p.Phe215Ser Uncertain significance Single submitter
- NIM1K p.Phe271Ile Uncertain significance Single submitter
- NIM1K p.Pro171Ser Uncertain significance Single submitter
- NIM1K p.Pro47Ser Uncertain significance Single submitter
- NIM1K p.Ser282Gly Uncertain significance Single submitter
- NIM1K p.Ser359Gly Uncertain significance Single submitter
- NIM1K p.Ser359Ile Uncertain significance Single submitter
- NIM1K p.Ser402Arg Uncertain significance Single submitter
- NIM1K p.Thr66Met Uncertain significance Single submitter
- NIM1K p.Tyr152Cys Uncertain significance Single submitter
- NIM1K p.Tyr204His Uncertain significance Single submitter
- NIM1K p.Tyr5Cys Uncertain significance Single submitter
- NIM1K p.Val386Leu Uncertain significance Single submitter
- NIM1K p.Val4Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- NIM1K p.Asp322Val Uncertain significance Single submitter
- NIM1K p.Gly327Arg Uncertain significance Single submitter
- NIM1K p.Leu148Val Uncertain significance Single submitter
- NIM1K p.Pro47Arg Uncertain significance Single submitter
- NIM1K p.Ser169Phe Uncertain significance Single submitter
- NIM1K p.Val276Met Uncertain significance Single submitter
- NIM1K p.Val294Met Uncertain significance Single submitter
All NIM1K variants
Uncertain significance 57
- p.Ala153Ser Single submitter
- p.Ala237Pro Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Arg135His Single submitter
- p.Arg18Gln Single submitter ⚠
- p.Arg18Pro Single submitter ⚠
- p.Arg380His Single submitter ⚠
- p.Arg393Thr Single submitter
- p.Arg421Cys Single submitter ⚠
- p.Arg427Ile Single submitter ⚠
- p.Arg43Cys Single submitter ⚠
- p.Asn190Lys Single submitter ⚠
- p.Asn7Ser Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp317Asn Single submitter ⚠
- p.Asp322Val Single submitter ⚠
- p.Glu121Gln Single submitter ⚠
- p.Glu369Gly Single submitter ⚠
- p.Gly154Ala Single submitter ⚠
- p.Gly154Val Single submitter ⚠
- p.Gly160Val Single submitter ⚠
- p.Gly304Ala Single submitter ⚠
- p.Gly327Arg Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.His299Arg Single submitter ⚠
- p.His343Tyr Single submitter ⚠
- p.Ile134Asn Single submitter ⚠
- p.Ile176Val Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Leu148Val Single submitter ⚠
- p.Lys113Thr Single submitter ⚠
- p.Lys222Arg Single submitter ⚠
- p.Met226Ile Single submitter ⚠
- p.Met226Val Single submitter ⚠
- p.Phe215Ser Single submitter ⚠
- p.Phe271Ile Single submitter ⚠
- p.Pro171Ser Single submitter ⚠
- p.Pro47Arg Single submitter ⚠
- p.Pro47Ser Single submitter ⚠
- p.Ser169Phe Single submitter ⚠
- p.Ser282Gly Single submitter ⚠
- p.Ser359Gly Single submitter ⚠
- p.Ser359Ile Single submitter ⚠
- p.Ser402Arg Single submitter ⚠
- p.Thr46Met Single submitter
- p.Thr66Met Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr204His Single submitter ⚠
- p.Tyr5Cys Single submitter ⚠
- p.Val184Met Single submitter
- p.Val276Met Single submitter ⚠
- p.Val294Met Single submitter ⚠
- p.Val386Leu Single submitter ⚠
- p.Val386Phe Single submitter
- p.Val4Ala Single submitter ⚠