NLK — 32 ClinVar variants
All ClinVar germline NLK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
32 Uncertain significance
Full NLK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NLK p.Ala117Val Uncertain significance Single submitter
- NLK p.Ala119Gly Uncertain significance Single submitter
- NLK p.Ala343Gly Uncertain significance Single submitter
- NLK p.Ala343Ser Uncertain significance Single submitter
- NLK p.Ala423Thr Uncertain significance Single submitter
- NLK p.Ala8Val Uncertain significance Single submitter
- NLK p.Arg316His Uncertain significance Single submitter
- NLK p.Arg406Met Uncertain significance Single submitter
- NLK p.Arg475Gln Uncertain significance Single submitter
- NLK p.Arg7Thr Uncertain significance Single submitter
- NLK p.Asn320Ser Uncertain significance Single submitter
- NLK p.Gln66Arg Uncertain significance Single submitter
- NLK p.His296Pro Uncertain significance Single submitter
- NLK p.His62Arg Uncertain significance Single submitter
- NLK p.His62Gln Uncertain significance Single submitter
- NLK p.Ile138Val Uncertain significance Single submitter
- NLK p.Ile265Val Uncertain significance Single submitter
- NLK p.Leu3Val Uncertain significance Single submitter
- NLK p.Pro36Ser Uncertain significance Single submitter
- NLK p.Pro380Ala Uncertain significance Single submitter
- NLK p.Pro63Ala Uncertain significance Single submitter
- NLK p.Pro63Arg Uncertain significance Single submitter
- NLK p.Ser70Thr Uncertain significance Single submitter
- NLK p.Tyr216Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- NLK p.Ala76Thr Uncertain significance Single submitter
- NLK p.Ala77Gly Uncertain significance Single submitter
- NLK p.Glu213Asp Uncertain significance Single submitter
- NLK p.His28Gln Uncertain significance Single submitter
- NLK p.His29Asn Uncertain significance Single submitter
- NLK p.His45Arg Uncertain significance Single submitter
- NLK p.Pro40Arg Uncertain significance Single submitter
- NLK p.Thr445Ile Uncertain significance Single submitter
All NLK variants
Uncertain significance 32
- p.Ala117Val Single submitter ⚠
- p.Ala119Gly Single submitter ⚠
- p.Ala343Gly Single submitter ⚠
- p.Ala343Ser Single submitter ⚠
- p.Ala423Thr Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala77Gly Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg316His Single submitter ⚠
- p.Arg406Met Single submitter ⚠
- p.Arg475Gln Single submitter ⚠
- p.Arg7Thr Single submitter ⚠
- p.Asn320Ser Single submitter ⚠
- p.Gln66Arg Single submitter ⚠
- p.Glu213Asp Single submitter ⚠
- p.His28Gln Single submitter ⚠
- p.His296Pro Single submitter ⚠
- p.His29Asn Single submitter ⚠
- p.His45Arg Single submitter ⚠
- p.His62Arg Single submitter ⚠
- p.His62Gln Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Ile265Val Single submitter ⚠
- p.Leu3Val Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Pro380Ala Single submitter ⚠
- p.Pro40Arg Single submitter ⚠
- p.Pro63Ala Single submitter ⚠
- p.Pro63Arg Single submitter ⚠
- p.Ser70Thr Single submitter ⚠
- p.Thr445Ile Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠