NLN — 104 ClinVar variants
All ClinVar germline NLN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
1 Benign · 3 Likely benign · 100 Uncertain significance
Full NLN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NLN p.Ala120Glu Uncertain significance Single submitter
- NLN p.Ala218Val Uncertain significance Single submitter
- NLN p.Ala36Thr Uncertain significance Single submitter
- NLN p.Arg119Gln Uncertain significance Single submitter
- NLN p.Arg131Cys Uncertain significance Single submitter
- NLN p.Arg131His Uncertain significance Single submitter
- NLN p.Arg261Gly Uncertain significance Single submitter
- NLN p.Arg287Gln Uncertain significance Single submitter
- NLN p.Arg334Gln Uncertain significance Single submitter
- NLN p.Arg483His Uncertain significance Single submitter
- NLN p.Arg577Pro Uncertain significance Single submitter
- NLN p.Asn46Ser Uncertain significance Single submitter
- NLN p.Asp154Asn Uncertain significance Single submitter
- NLN p.Glu151Asp Uncertain significance Single submitter
- NLN p.Glu370Lys Uncertain significance Single submitter
- NLN p.Gly140Val Uncertain significance Single submitter
- NLN p.Gly453Arg Uncertain significance Single submitter
- NLN p.Gly517Arg Uncertain significance Single submitter
- NLN p.Gly674Arg Uncertain significance Single submitter
- NLN p.His299Gln Uncertain significance Single submitter
- NLN p.His497Arg Uncertain significance Single submitter
- NLN p.His504Tyr Uncertain significance Single submitter
- NLN p.Ile134Thr Uncertain significance Single submitter
- NLN p.Ile80Thr Uncertain significance Single submitter
- NLN p.Leu129Pro Uncertain significance Single submitter
- NLN p.Leu220Phe Uncertain significance Single submitter
- NLN p.Leu394Pro Uncertain significance Single submitter
- NLN p.Leu439His Uncertain significance Single submitter
- NLN p.Leu568Met Uncertain significance Single submitter
- NLN p.Leu686Phe Uncertain significance Single submitter
- NLN p.Leu89Pro Uncertain significance Single submitter
- NLN p.Lys127Glu Uncertain significance Single submitter
- NLN p.Lys292Arg Uncertain significance Single submitter
- NLN p.Met138Lys Uncertain significance Single submitter
- NLN p.Met503Ile Uncertain significance Single submitter
- NLN p.Met697Val Uncertain significance Single submitter
- NLN p.Phe384Leu Uncertain significance Single submitter
- NLN p.Phe405Tyr Uncertain significance Single submitter
- NLN p.Ser417Asn Uncertain significance Single submitter
- NLN p.Ser529Leu Uncertain significance Single submitter
- NLN p.Thr277Ser Uncertain significance Single submitter
- NLN p.Thr298Ser Uncertain significance Single submitter
- NLN p.Thr419Lys Uncertain significance Single submitter
- NLN p.Val303Ile Uncertain significance Single submitter
- NLN p.Val42Met Uncertain significance Single submitter
- NLN p.Val473Met Uncertain significance Single submitter
- NLN p.Val502Met Uncertain significance Single submitter
- NLN p.Val520Leu Uncertain significance Single submitter
- NLN p.Val539Leu Uncertain significance Single submitter
- NLN p.Val661Ile Uncertain significance Single submitter
Predictors split 50
The independent predictors disagree with each other — read with care.
- NLN p.Arg164Gln Uncertain significance Single submitter
- NLN p.Arg262Ile Uncertain significance Single submitter
- NLN p.Arg314Cys Uncertain significance Single submitter
- NLN p.Arg465Gln Uncertain significance Single submitter
- NLN p.Arg465Trp Uncertain significance Single submitter
- NLN p.Arg543Gln Uncertain significance Single submitter
- NLN p.Arg577His Uncertain significance Single submitter
- NLN p.Arg60Gly Uncertain significance Single submitter
- NLN p.Arg688Cys Uncertain significance Single submitter
- NLN p.Arg688His Uncertain significance Single submitter
- NLN p.Arg699Gly Uncertain significance Single submitter
- NLN p.Asp490Asn Uncertain significance Single submitter
- NLN p.Asp540Asn Uncertain significance Single submitter
- NLN p.Asp558Val Uncertain significance Single submitter
- NLN p.Asp73Asn Uncertain significance Single submitter
- NLN p.Cys199Arg Uncertain significance Single submitter
- NLN p.Glu259Ala Uncertain significance Single submitter
- NLN p.Glu391Gly Uncertain significance Single submitter
- NLN p.Glu406Lys Uncertain significance Single submitter
- NLN p.Gly453Ser Uncertain significance Single submitter
- NLN p.Gly463Ala Uncertain significance Single submitter
- NLN p.Gly482Ser Uncertain significance Single submitter
- NLN p.His299Tyr Uncertain significance Single submitter
- NLN p.Ile579Met Uncertain significance Single submitter
- NLN p.Ile579Val Uncertain significance Single submitter
- NLN p.Leu329Val Uncertain significance Single submitter
- NLN p.Leu608Val Uncertain significance Single submitter
- NLN p.Leu78Arg Uncertain significance Single submitter
- NLN p.Lys171Thr Uncertain significance Single submitter
- NLN p.Lys325Asn Uncertain significance Single submitter
- NLN p.Lys550Glu Uncertain significance Single submitter
- NLN p.Met24Thr Uncertain significance Single submitter
- NLN p.Met644Ile Uncertain significance Single submitter
- NLN p.Pro484Ala Uncertain significance Single submitter
- NLN p.Pro484Ser Uncertain significance Single submitter
- NLN p.Pro54Leu Uncertain significance Single submitter
- NLN p.Pro619Ser Uncertain significance Single submitter
- NLN p.Pro659Leu Uncertain significance Single submitter
- NLN p.Ser323Gly Uncertain significance Single submitter
- NLN p.Ser587Phe Uncertain significance Single submitter
- NLN p.Ser605Pro Uncertain significance Single submitter
- NLN p.Thr123Arg Uncertain significance Single submitter
- NLN p.Thr211Ile Uncertain significance Single submitter
- NLN p.Thr270Ile Uncertain significance Single submitter
- NLN p.Thr298Ile Uncertain significance Single submitter
- NLN p.Thr428Ile Uncertain significance Single submitter
- NLN p.Tyr383Cys Uncertain significance Single submitter
- NLN p.Tyr648Cys Uncertain significance Single submitter
- NLN p.Tyr85Cys Uncertain significance Single submitter
- NLN p.Val101Glu Uncertain significance Single submitter
All NLN variants
Benign 1
- c.1527+15del Single submitter
Likely benign 3
- p.Arg314His Single submitter
- p.Thr288Ala Single submitter
- p.Val539Ile Single submitter
Uncertain significance 100
- p.Ala120Glu Single submitter ⚠
- p.Ala218Val Single submitter ⚠
- p.Ala36Thr Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg164Gln Single submitter ⚠
- p.Arg261Gly Single submitter ⚠
- p.Arg262Ile Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg483His Single submitter ⚠
- p.Arg543Gln Single submitter ⚠
- p.Arg577His Single submitter ⚠
- p.Arg577Pro Single submitter ⚠
- p.Arg60Gly Single submitter ⚠
- p.Arg688Cys Single submitter ⚠
- p.Arg688His Single submitter ⚠
- p.Arg699Gly Single submitter ⚠
- p.Asn46Ser Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp490Asn Single submitter ⚠
- p.Asp540Asn Single submitter ⚠
- p.Asp558Val Single submitter ⚠
- p.Asp73Asn Single submitter ⚠
- p.Cys199Arg Single submitter ⚠
- p.Glu151Asp Single submitter ⚠
- p.Glu259Ala Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu391Gly Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Gly140Val Single submitter ⚠
- p.Gly453Arg Single submitter ⚠
- p.Gly453Ser Single submitter ⚠
- p.Gly463Ala Single submitter ⚠
- p.Gly482Ser Single submitter ⚠
- p.Gly517Arg Single submitter ⚠
- p.Gly674Arg Single submitter ⚠
- p.His299Gln Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.His497Arg Single submitter ⚠
- p.His504Tyr Single submitter ⚠
- p.Ile134Thr Single submitter ⚠
- p.Ile579Met Single submitter ⚠
- p.Ile579Val Single submitter ⚠
- p.Ile80Thr Single submitter ⚠
- p.Leu129Pro Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Leu329Val Single submitter ⚠
- p.Leu394Pro Single submitter ⚠
- p.Leu439His Single submitter ⚠
- p.Leu568Met Single submitter ⚠
- p.Leu608Val Single submitter ⚠
- p.Leu686Phe Single submitter ⚠
- p.Leu78Arg Single submitter ⚠
- p.Leu89Pro Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys171Thr Single submitter ⚠
- p.Lys292Arg Single submitter ⚠
- p.Lys325Asn Single submitter ⚠
- p.Lys550Glu Single submitter ⚠
- p.Met138Lys Single submitter ⚠
- p.Met24Thr Single submitter ⚠
- p.Met503Ile Single submitter ⚠
- p.Met644Ile Single submitter ⚠
- p.Met697Val Single submitter ⚠
- p.Phe384Leu Single submitter ⚠
- p.Phe405Tyr Single submitter ⚠
- p.Pro484Ala Single submitter ⚠
- p.Pro484Ser Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro619Ser Single submitter ⚠
- p.Pro659Leu Single submitter ⚠
- p.Ser323Gly Single submitter ⚠
- p.Ser417Asn Single submitter ⚠
- p.Ser529Leu Single submitter ⚠
- p.Ser587Phe Single submitter ⚠
- p.Ser605Pro Single submitter ⚠
- p.Thr123Arg Single submitter ⚠
- p.Thr211Ile Single submitter ⚠
- p.Thr270Ile Single submitter ⚠
- p.Thr277Ser Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
- p.Thr298Ser Single submitter ⚠
- p.Thr419Lys Single submitter ⚠
- p.Thr428Ile Single submitter ⚠
- p.Tyr383Cys Single submitter ⚠
- p.Tyr648Cys Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Val101Glu Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val42Met Single submitter ⚠
- p.Val473Met Single submitter ⚠
- p.Val502Met Single submitter ⚠
- p.Val520Leu Single submitter ⚠
- p.Val539Leu Single submitter ⚠
- p.Val661Ile Single submitter ⚠