NLRP14 — 230 ClinVar variants
All ClinVar germline NLRP14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 160 flagged for review →
46 Benign · 18 Likely benign · 166 Uncertain significance
Full NLRP14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 160
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 134
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NLRP14 p.Ala1054Pro Uncertain significance Single submitter
- NLRP14 p.Ala109Pro Uncertain significance Single submitter
- NLRP14 p.Ala155Gly Uncertain significance Single submitter
- NLRP14 p.Ala301Pro Uncertain significance Single submitter
- NLRP14 p.Ala593Thr Uncertain significance Single submitter
- NLRP14 p.Ala593Val Uncertain significance Single submitter
- NLRP14 p.Ala598Gly Uncertain significance Single submitter
- NLRP14 p.Ala944Val Uncertain significance Single submitter
- NLRP14 p.Ala99Val Uncertain significance Single submitter
- NLRP14 p.Arg127Ser Uncertain significance Single submitter
- NLRP14 p.Arg546Gly Uncertain significance Single submitter
- NLRP14 p.Arg629Gly Uncertain significance Single submitter
- NLRP14 p.Arg632Ser Uncertain significance Single submitter
- NLRP14 p.Arg844Ile Uncertain significance Single submitter
- NLRP14 p.Arg881Cys Uncertain significance Single submitter
- NLRP14 p.Asn265Lys Uncertain significance Single submitter
- NLRP14 p.Asn446Ser Uncertain significance Single submitter
- NLRP14 p.Asn48Lys Uncertain significance Single submitter
- NLRP14 p.Asn549Lys Uncertain significance Single submitter
- NLRP14 p.Asn549Ser Uncertain significance Single submitter
- NLRP14 p.Asn608His Uncertain significance Single submitter
- NLRP14 p.Asn96Lys Uncertain significance Single submitter
- NLRP14 p.Asp1056Glu Uncertain significance Single submitter
- NLRP14 p.Asp115His Uncertain significance Single submitter
- NLRP14 p.Asp139Tyr Uncertain significance Single submitter
- NLRP14 p.Asp158Ala Uncertain significance Single submitter
- NLRP14 p.Asp169Asn Uncertain significance Single submitter
- NLRP14 p.Asp57Asn Uncertain significance Single submitter
- NLRP14 p.Asp679Glu Uncertain significance Single submitter
- NLRP14 p.Asp800Asn Uncertain significance Single submitter
- NLRP14 p.Asp922Glu Uncertain significance Single submitter
- NLRP14 p.Asp922Val Uncertain significance Single submitter
- NLRP14 p.Asp968Tyr Uncertain significance Single submitter
- NLRP14 p.Cys1002Ser Uncertain significance Single submitter
- NLRP14 p.Cys610Tyr Uncertain significance Single submitter
- NLRP14 p.Gln113Glu Uncertain significance Single submitter
- NLRP14 p.Gln175Arg Uncertain significance Single submitter
- NLRP14 p.Gln317Arg Uncertain significance Single submitter
- NLRP14 p.Gln467His Uncertain significance Single submitter
- NLRP14 p.Gln590Leu Uncertain significance Single submitter
- NLRP14 p.Gln597Lys Uncertain significance Single submitter
- NLRP14 p.Gln989His Uncertain significance Single submitter
- NLRP14 p.Glu148Lys Uncertain significance Single submitter
- NLRP14 p.Glu156Lys Uncertain significance Single submitter
- NLRP14 p.Glu56Val Uncertain significance Single submitter
- NLRP14 p.Glu696Asp Uncertain significance Single submitter
- NLRP14 p.Glu766Gln Uncertain significance Single submitter
- NLRP14 p.Gly1027Arg Uncertain significance Single submitter
- NLRP14 p.Gly153Arg Uncertain significance Single submitter
- NLRP14 p.Gly173Ser Uncertain significance Single submitter
- NLRP14 p.Gly80Asp Uncertain significance Single submitter
- NLRP14 p.His151Arg Uncertain significance Single submitter
- NLRP14 p.His152Tyr Uncertain significance Single submitter
- NLRP14 p.His624Gln Uncertain significance Single submitter
- NLRP14 p.His695Tyr Uncertain significance Single submitter
- NLRP14 p.His755Gln Uncertain significance Single submitter
- NLRP14 p.His869Gln Uncertain significance Single submitter
- NLRP14 p.His904Arg Uncertain significance Single submitter
- NLRP14 p.Ile1011Thr Uncertain significance Single submitter
- NLRP14 p.Ile154Thr Uncertain significance Single submitter
- NLRP14 p.Ile178Val Uncertain significance Single submitter
- NLRP14 p.Ile233Leu Uncertain significance Single submitter
- NLRP14 p.Ile244Val Uncertain significance Single submitter
- NLRP14 p.Ile257Val Uncertain significance Single submitter
- NLRP14 p.Ile339Met Uncertain significance Single submitter
- NLRP14 p.Ile631Phe Uncertain significance Single submitter
- NLRP14 p.Ile643Leu Uncertain significance Single submitter
- NLRP14 p.Ile783Val Uncertain significance Single submitter
- NLRP14 p.Ile95Met Uncertain significance Single submitter
- NLRP14 p.Ile988Phe Uncertain significance Single submitter
- NLRP14 p.Leu1001Phe Uncertain significance Single submitter
- NLRP14 p.Leu1063Pro Uncertain significance Single submitter
- NLRP14 p.Leu205Val Uncertain significance Single submitter
- NLRP14 p.Leu232Phe Uncertain significance Single submitter
- NLRP14 p.Leu44Arg Uncertain significance Single submitter
- NLRP14 p.Leu615Val Uncertain significance Single submitter
- NLRP14 p.Leu616Phe Uncertain significance Single submitter
- NLRP14 p.Leu61Trp Uncertain significance Single submitter
- NLRP14 p.Leu887Phe Uncertain significance Single submitter
- NLRP14 p.Leu896Pro Uncertain significance Single submitter
- NLRP14 p.Lys1014Glu Uncertain significance Single submitter
- NLRP14 p.Lys52Arg Uncertain significance Single submitter
- NLRP14 p.Lys592Gln Uncertain significance Single submitter
- NLRP14 p.Lys612Asn Uncertain significance Single submitter
- NLRP14 p.Lys737Thr Uncertain significance Single submitter
- NLRP14 p.Lys77Glu Uncertain significance Single submitter
- NLRP14 p.Met248Val Uncertain significance Single submitter
- NLRP14 p.Met289Leu Uncertain significance Single submitter
- NLRP14 p.Met350Val Uncertain significance Single submitter
- NLRP14 p.Met461Ile Uncertain significance Single submitter
- NLRP14 p.Met461Thr Uncertain significance Single submitter
- NLRP14 p.Met552Ile Uncertain significance Single submitter
- NLRP14 p.Met564Ile Uncertain significance Single submitter
- NLRP14 p.Met732Ile Uncertain significance Single submitter
- NLRP14 p.Met863Thr Uncertain significance Single submitter
- NLRP14 p.Met937Ile Uncertain significance Single submitter
- NLRP14 p.Phe1055Val Uncertain significance Single submitter
- NLRP14 p.Phe10Cys Uncertain significance Single submitter
- NLRP14 p.Phe353Leu Uncertain significance Single submitter
- NLRP14 p.Phe924Ser Uncertain significance Single submitter
- NLRP14 p.Pro176Ser Uncertain significance Single submitter
- NLRP14 p.Pro271Thr Uncertain significance Single submitter
- NLRP14 p.Pro40Thr Uncertain significance Single submitter
- NLRP14 p.Pro507Ala Uncertain significance Single submitter
- NLRP14 p.Pro700Ser Uncertain significance Single submitter
- NLRP14 p.Ser1069Arg Uncertain significance Single submitter
- NLRP14 p.Ser1069Cys Uncertain significance Single submitter
- NLRP14 p.Ser228Arg Uncertain significance Single submitter
- NLRP14 p.Ser364Thr Uncertain significance Single submitter
- NLRP14 p.Ser4Thr Uncertain significance Single submitter
- NLRP14 p.Ser558Thr Uncertain significance Single submitter
- NLRP14 p.Ser570Arg Uncertain significance Single submitter
- NLRP14 p.Ser683Gly Uncertain significance Single submitter
- NLRP14 p.Ser73Gly Uncertain significance Single submitter
- NLRP14 p.Ser748Leu Uncertain significance Single submitter
- NLRP14 p.Ser901Cys Uncertain significance Single submitter
- NLRP14 p.Thr190Lys Uncertain significance Single submitter
- NLRP14 p.Thr409Ile Uncertain significance Single submitter
- NLRP14 p.Thr437Ser Uncertain significance Single submitter
- NLRP14 p.Thr453Ile Uncertain significance Single submitter
- NLRP14 p.Thr518Ile Uncertain significance Single submitter
- NLRP14 p.Thr526Ile Uncertain significance Single submitter
- NLRP14 p.Thr762Ser Uncertain significance Single submitter
- NLRP14 p.Thr903Arg Uncertain significance Single submitter
- NLRP14 p.Trp653Cys Uncertain significance Single submitter
- NLRP14 p.Tyr206Phe Uncertain significance Single submitter
- NLRP14 p.Tyr572Cys Uncertain significance Single submitter
- NLRP14 p.Tyr572His Uncertain significance Single submitter
- NLRP14 p.Val1032Gly Uncertain significance Single submitter
- NLRP14 p.Val119Glu Uncertain significance Single submitter
- NLRP14 p.Val168Met Uncertain significance Single submitter
- NLRP14 p.Val457Ile Uncertain significance Single submitter
- NLRP14 p.Val50Leu Uncertain significance Single submitter
- NLRP14 p.Val940Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- NLRP14 p.Leu1010Phe Benign Multiple submitters
- NLRP14 p.Ala489Gly Uncertain significance Single submitter
- NLRP14 p.Ala980Gly Uncertain significance Single submitter
- NLRP14 p.Ala980Thr Uncertain significance Single submitter
- NLRP14 p.Arg629Trp Uncertain significance Single submitter
- NLRP14 p.Arg925Trp Uncertain significance Single submitter
- NLRP14 p.Asn956Tyr Uncertain significance Single submitter
- NLRP14 p.Asp262Asn Uncertain significance Single submitter
- NLRP14 p.Gln761Pro Uncertain significance Single submitter
- NLRP14 p.Glu36Val Uncertain significance Single submitter
- NLRP14 p.Glu545Gly Uncertain significance Single submitter
- NLRP14 p.Gly742Ala Uncertain significance Single submitter
- NLRP14 p.Gly992Arg Uncertain significance Single submitter
- NLRP14 p.Ile692Asn Uncertain significance Single submitter
- NLRP14 p.Leu560Ser Uncertain significance Single submitter
- NLRP14 p.Leu675Ser Uncertain significance Single submitter
- NLRP14 p.Leu897Pro Uncertain significance Single submitter
- NLRP14 p.Met438Ile Uncertain significance Single submitter
- NLRP14 p.Phe342Leu Uncertain significance Single submitter
- NLRP14 p.Phe491Leu Uncertain significance Single submitter
- NLRP14 p.Ser455Phe Uncertain significance Single submitter
- NLRP14 p.Ser722Pro Uncertain significance Single submitter
- NLRP14 p.Ser779Pro Uncertain significance Single submitter
- NLRP14 p.Thr307Arg Uncertain significance Single submitter
- NLRP14 p.Tyr492Cys Uncertain significance Single submitter
- NLRP14 p.Tyr587Cys Uncertain significance Single submitter
All NLRP14 variants
Benign 46
- c.1958+74C>A Multiple submitters
- c.2124-36G>A Multiple submitters
- c.2292-104A>C Multiple submitters
- c.3146+85C>A Multiple submitters
- c.361+46T>G Multiple submitters
- c.-21-48T>A Multiple submitters
- p.Ala432Ser Multiple submitters
- p.Arg55Gln Multiple submitters
- p.Asn48Thr Multiple submitters
- p.Asn967= Multiple submitters
- p.Glu751= Multiple submitters
- p.Glu808Lys Multiple submitters
- p.Leu1010Phe Multiple submitters ⚠
- p.Lys108Ter Multiple submitters spermatogenic failure
- p.Lys92Arg Multiple submitters
- p.Phe166= Multiple submitters
- p.Phe400= Multiple submitters
- p.Tyr338= Multiple submitters
- c.1959-198G>T Single submitter
- c.2123+105C>T Single submitter
- c.2124-179G>T Single submitter
- c.2124-244A>T Single submitter
- c.2124-272T>C Single submitter
- c.2462+183A>G Single submitter
- c.2463-172C>T Single submitter
- c.2634-254T>G Single submitter
- c.2804+125_2804+128del Single submitter
- c.2805-305A>G Single submitter
- c.289+131del Single submitter
- c.289+262_289+275del Single submitter
- c.290-275A>T Single submitter
- c.2976-111A>C Single submitter
- c.2976-160A>C Single submitter
- c.362-320T>C Single submitter
- c.362-322A>G Single submitter
- p.Asp86Val Single submitter spermatogenic failure
- p.Val179Met Single submitter
- p.Ala432= No assertion criteria NLRP14-related disorder
- p.Asp3Gly No assertion criteria NLRP14-related disorder
- p.Gly242Asp No assertion criteria NLRP14-related disorder
- p.Leu16= No assertion criteria NLRP14-related disorder
- p.Leu954Ser No assertion criteria NLRP14-related disorder
- p.Lys51Arg No assertion criteria NLRP14-related disorder
- p.Met1019Ile No assertion criteria NLRP14-related disorder
- p.Ser951Thr No assertion criteria NLRP14-related disorder
- p.Ser98Leu No assertion criteria NLRP14-related disorder
Likely benign 18
- p.Arg626Gln Single submitter
- p.Arg657His Single submitter
- p.Arg881His Single submitter
- p.Asp1086Asn Single submitter
- p.Leu1006= Single submitter
- p.Lys1036Glu Single submitter
- p.Lys612Glu Single submitter
- p.Met248Ile Single submitter
- p.Phe33Leu Single submitter
- p.Thr311Ala Single submitter
- c.1958+6T>C No assertion criteria NLRP14-related disorder
- p.Asp12= No assertion criteria NLRP14-related disorder
- p.Cys750Tyr No assertion criteria NLRP14-related disorder
- p.Gln484= No assertion criteria NLRP14-related disorder
- p.Glu21Lys No assertion criteria NLRP14-related disorder
- p.Thr191= No assertion criteria NLRP14-related disorder
- p.Thr397Ile No assertion criteria NLRP14-related disorder
- p.Val441Met No assertion criteria NLRP14-related disorder
Uncertain significance 166
- p.Ala1054Pro Single submitter ⚠
- p.Ala109Pro Single submitter ⚠
- p.Ala155Gly Single submitter ⚠
- p.Ala301Pro Single submitter ⚠
- p.Ala489Gly Single submitter ⚠
- p.Ala593Thr Single submitter ⚠
- p.Ala593Val Single submitter ⚠
- p.Ala598Gly Single submitter ⚠
- p.Ala944Val Single submitter ⚠
- p.Ala980Gly Single submitter ⚠
- p.Ala980Thr Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg127Ser Single submitter ⚠
- p.Arg546Gly Single submitter ⚠
- p.Arg629Gly Single submitter ⚠
- p.Arg629Trp Single submitter ⚠
- p.Arg632Ser Single submitter ⚠
- p.Arg844Ile Single submitter ⚠
- p.Arg881Cys Single submitter ⚠
- p.Arg925Trp Single submitter ⚠
- p.Asn265Lys Single submitter ⚠
- p.Asn446Ser Single submitter ⚠
- p.Asn48Lys Single submitter ⚠
- p.Asn549Lys Single submitter ⚠
- p.Asn549Ser Single submitter ⚠
- p.Asn608His Single submitter ⚠
- p.Asn956Tyr Single submitter ⚠
- p.Asn96Lys Single submitter ⚠
- p.Asp1056Glu Single submitter ⚠
- p.Asp115His Single submitter ⚠
- p.Asp139Tyr Single submitter ⚠
- p.Asp158Ala Single submitter ⚠
- p.Asp169Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp57Asn Single submitter ⚠
- p.Asp679Glu Single submitter ⚠
- p.Asp735Val Single submitter
- p.Asp800Asn Single submitter ⚠
- p.Asp922Glu Single submitter ⚠
- p.Asp922Val Single submitter ⚠
- p.Asp963Gly Single submitter
- p.Asp968Tyr Single submitter ⚠
- p.Cys1002Ser Single submitter ⚠
- p.Cys610Tyr Single submitter ⚠
- p.Gln113Glu Single submitter ⚠
- p.Gln175Arg Single submitter ⚠
- p.Gln317Arg Single submitter ⚠
- p.Gln467His Single submitter ⚠
- p.Gln590Leu Single submitter ⚠
- p.Gln597Lys Single submitter ⚠
- p.Gln761Pro Single submitter ⚠
- p.Gln989His Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu36Val Single submitter ⚠
- p.Glu545Gly Single submitter ⚠
- p.Glu56Val Single submitter ⚠
- p.Glu696Asp Single submitter ⚠
- p.Glu766Gln Single submitter ⚠
- p.Gly1027Arg Single submitter ⚠
- p.Gly153Arg Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.Gly451Trp Single submitter
- p.Gly742Ala Single submitter ⚠
- p.Gly80Asp Single submitter ⚠
- p.Gly992Arg Single submitter ⚠
- p.His151Arg Single submitter ⚠
- p.His152Tyr Single submitter ⚠
- p.His624Gln Single submitter ⚠
- p.His695Tyr Single submitter ⚠
- p.His699Gln Single submitter
- p.His755Gln Single submitter ⚠
- p.His869Gln Single submitter ⚠
- p.His904Arg Single submitter ⚠
- p.Ile1011Thr Single submitter ⚠
- p.Ile154Thr Single submitter ⚠
- p.Ile178Val Single submitter ⚠
- p.Ile233Leu Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile257Val Single submitter ⚠
- p.Ile339Met Single submitter ⚠
- p.Ile631Phe Single submitter ⚠
- p.Ile643Leu Single submitter ⚠
- p.Ile692Asn Single submitter ⚠
- p.Ile783Val Single submitter ⚠
- p.Ile95Met Single submitter ⚠
- p.Ile988Phe Single submitter ⚠
- p.Leu1001Phe Single submitter ⚠
- p.Leu1063Pro Single submitter ⚠
- p.Leu161Pro Single submitter
- p.Leu205Val Single submitter ⚠
- p.Leu232Phe Single submitter ⚠
- p.Leu44Arg Single submitter ⚠
- p.Leu560Ser Single submitter ⚠
- p.Leu615Val Single submitter ⚠
- p.Leu616Phe Single submitter ⚠
- p.Leu61Trp Single submitter ⚠
- p.Leu675Ser Single submitter ⚠
- p.Leu887Phe Single submitter ⚠
- p.Leu896Pro Single submitter ⚠
- p.Leu897Pro Single submitter ⚠
- p.Lys1014Glu Single submitter ⚠
- p.Lys52Arg Single submitter ⚠
- p.Lys592Gln Single submitter ⚠
- p.Lys612Asn Single submitter ⚠
- p.Lys737Thr Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Met248Val Single submitter ⚠
- p.Met289Leu Single submitter ⚠
- p.Met350Val Single submitter ⚠
- p.Met438Ile Single submitter ⚠
- p.Met461Ile Single submitter ⚠
- p.Met461Thr Single submitter ⚠
- p.Met552Ile Single submitter ⚠
- p.Met564Ile Single submitter ⚠
- p.Met732Ile Single submitter ⚠
- p.Met863Thr Single submitter ⚠
- p.Met937Ile Single submitter ⚠
- p.Phe1055Val Single submitter ⚠
- p.Phe10Cys Single submitter ⚠
- p.Phe342Leu Single submitter ⚠
- p.Phe353Leu Single submitter ⚠
- p.Phe491Leu Single submitter ⚠
- p.Phe924Ser Single submitter ⚠
- p.Pro176Ser Single submitter ⚠
- p.Pro271Thr Single submitter ⚠
- p.Pro369Thr Single submitter
- p.Pro40Thr Single submitter ⚠
- p.Pro507Ala Single submitter ⚠
- p.Pro700Ser Single submitter ⚠
- p.Ser1069Arg Single submitter ⚠
- p.Ser1069Cys Single submitter ⚠
- p.Ser228Arg Single submitter ⚠
- p.Ser364Thr Single submitter ⚠
- p.Ser455Phe Single submitter ⚠
- p.Ser4Thr Single submitter ⚠
- p.Ser558Thr Single submitter ⚠
- p.Ser570Arg Single submitter ⚠
- p.Ser619Tyr Single submitter
- p.Ser683Gly Single submitter ⚠
- p.Ser722Pro Single submitter ⚠
- p.Ser73Gly Single submitter ⚠
- p.Ser748Leu Single submitter ⚠
- p.Ser779Pro Single submitter ⚠
- p.Ser901Cys Single submitter ⚠
- p.Thr190Lys Single submitter ⚠
- p.Thr307Arg Single submitter ⚠
- p.Thr409Ile Single submitter ⚠
- p.Thr437Ser Single submitter ⚠
- p.Thr453Ile Single submitter ⚠
- p.Thr518Ile Single submitter ⚠
- p.Thr526Ile Single submitter ⚠
- p.Thr762Ser Single submitter ⚠
- p.Thr903Arg Single submitter ⚠
- p.Trp653Cys Single submitter ⚠
- p.Tyr206Phe Single submitter ⚠
- p.Tyr492Cys Single submitter ⚠
- p.Tyr572Cys Single submitter ⚠
- p.Tyr572His Single submitter ⚠
- p.Tyr587Cys Single submitter ⚠
- p.Val1032Gly Single submitter ⚠
- p.Val119Glu Single submitter ⚠
- p.Val168Met Single submitter ⚠
- p.Val457Ile Single submitter ⚠
- p.Val50Leu Single submitter ⚠
- p.Val940Ile Single submitter ⚠