NMBR — 68 ClinVar variants
All ClinVar germline NMBR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
1 Benign · 1 Benign/Likely benign · 7 Likely benign · 59 Uncertain significance
Full NMBR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NMBR p.Ala136Asp Uncertain significance Single submitter
- NMBR p.Ala179Val Uncertain significance Single submitter
- NMBR p.Ala185Val Uncertain significance Single submitter
- NMBR p.Ala32Gly Uncertain significance Single submitter
- NMBR p.Ala369Val Uncertain significance Single submitter
- NMBR p.Ala389Val Uncertain significance Single submitter
- NMBR p.Ala73Ser Uncertain significance Single submitter
- NMBR p.Arg261Trp Uncertain significance Single submitter
- NMBR p.Arg263His Uncertain significance Single submitter
- NMBR p.Arg263Pro Uncertain significance Single submitter
- NMBR p.Arg289Gln Uncertain significance Single submitter
- NMBR p.Arg310Gln Uncertain significance Single submitter
- NMBR p.Arg43His Uncertain significance Single submitter
- NMBR p.Asn245His Uncertain significance Single submitter
- NMBR p.Glu26Ala Uncertain significance Single submitter
- NMBR p.Gly128Arg Uncertain significance Single submitter
- NMBR p.Gly128Val Uncertain significance Single submitter
- NMBR p.Gly381Arg Uncertain significance Single submitter
- NMBR p.Gly57Ala Uncertain significance Single submitter
- NMBR p.Ile145Thr Uncertain significance Single submitter
- NMBR p.Ile223Met Uncertain significance Single submitter
- NMBR p.Ile42Phe Uncertain significance Single submitter
- NMBR p.Leu174Gln Uncertain significance Single submitter
- NMBR p.Leu285Ile Uncertain significance Single submitter
- NMBR p.Leu327Val Uncertain significance Single submitter
- NMBR p.Leu354Pro Uncertain significance Single submitter
- NMBR p.Leu355Val Uncertain significance Single submitter
- NMBR p.Leu51Met Uncertain significance Single submitter
- NMBR p.Leu91Val Uncertain significance Single submitter
- NMBR p.Lys117Arg Uncertain significance Single submitter
- NMBR p.Lys237Gln Uncertain significance Single submitter
- NMBR p.Lys255Glu Uncertain significance Single submitter
- NMBR p.Lys344Thr Uncertain significance Single submitter
- NMBR p.Met151Leu Uncertain significance Single submitter
- NMBR p.Phe275Ile Uncertain significance Single submitter
- NMBR p.Pro148Ala Uncertain significance Single submitter
- NMBR p.Pro202Leu Uncertain significance Single submitter
- NMBR p.Pro224Ala Uncertain significance Single submitter
- NMBR p.Ser10Trp Uncertain significance Single submitter
- NMBR p.Ser138Arg Uncertain significance Single submitter
- NMBR p.Ser171Pro Uncertain significance Single submitter
- NMBR p.Ser299Thr Uncertain significance Single submitter
- NMBR p.Ser313Arg Uncertain significance Single submitter
- NMBR p.Ser313Thr Uncertain significance Single submitter
- NMBR p.Ser48Thr Uncertain significance Single submitter
- NMBR p.Thr306Ala Uncertain significance Single submitter
- NMBR p.Thr36Ala Uncertain significance Single submitter
- NMBR p.Thr38Met Uncertain significance Single submitter
- NMBR p.Tyr201His Uncertain significance Single submitter
- NMBR p.Tyr288Asn Uncertain significance Single submitter
- NMBR p.Val127Ala Uncertain significance Single submitter
- NMBR p.Val131Met Uncertain significance Single submitter
- NMBR p.Val172Met Uncertain significance Single submitter
- NMBR p.Val305Leu Uncertain significance Single submitter
- NMBR p.Val97Asp Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All NMBR variants
Benign 1
- p.Leu390Met Single submitter
Benign/Likely benign 1
- p.Ile46= Multiple submitters
Likely benign 7
- p.Arg310Trp Multiple submitters
- p.Ser358= Multiple submitters
- p.Ala359= Single submitter
- p.Ile167Val Single submitter
- p.Met151Ile Single submitter
- p.Met384Val Single submitter
- p.Ser76Asn Single submitter
Uncertain significance 59
- p.Ala136Asp Single submitter ⚠
- p.Ala179Val Single submitter ⚠
- p.Ala185Val Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala32Gly Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala73Ser Single submitter ⚠
- p.Arg261Trp Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg263Pro Single submitter ⚠
- p.Arg289Gln Single submitter ⚠
- p.Arg289Trp Single submitter
- p.Arg310Gln Single submitter ⚠
- p.Arg43His Single submitter ⚠
- p.Asn245His Single submitter ⚠
- p.Glu26Ala Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly128Val Single submitter ⚠
- p.Gly381Arg Single submitter ⚠
- p.Gly57Ala Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile223Met Single submitter ⚠
- p.Ile42Phe Single submitter ⚠
- p.Leu174Gln Single submitter ⚠
- p.Leu285Ile Single submitter ⚠
- p.Leu327Val Single submitter ⚠
- p.Leu354Pro Single submitter ⚠
- p.Leu355Val Single submitter ⚠
- p.Leu51Met Single submitter ⚠
- p.Leu91Val Single submitter ⚠
- p.Lys117Arg Single submitter ⚠
- p.Lys237Gln Single submitter ⚠
- p.Lys255Glu Single submitter ⚠
- p.Lys344Thr Single submitter ⚠
- p.Met151Leu Single submitter ⚠
- p.Phe275Ile Single submitter ⚠
- p.Pro148Ala Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro224Ala Single submitter ⚠
- p.Ser10Trp Single submitter ⚠
- p.Ser138Arg Single submitter ⚠
- p.Ser154Leu Single submitter ⚠
- p.Ser171Pro Single submitter ⚠
- p.Ser299Thr Single submitter ⚠
- p.Ser313Arg Single submitter ⚠
- p.Ser313Thr Single submitter ⚠
- p.Ser48Thr Single submitter ⚠
- p.Thr306Ala Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Tyr201His Single submitter ⚠
- p.Tyr288Asn Single submitter ⚠
- p.Val127Ala Single submitter ⚠
- p.Val131Met Single submitter ⚠
- p.Val172Met Single submitter ⚠
- p.Val305Leu Single submitter ⚠
- p.Val45Met Single submitter ⚠
- p.Val97Asp Single submitter ⚠