NME1 — 8 ClinVar variants
All ClinVar germline NME1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
4 Benign · 1 Likely benign · 3 Uncertain significance
Full NME1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All NME1 variants
Benign 4
- c.341+10T>G Multiple submitters
- c.342-53C>A Single submitter
- c.-5+600C>G Single submitter
- c.-5+604G>A Single submitter
Likely benign 1
- p.Thr143Met Single submitter ⚠
Uncertain significance 3
- p.Tyr151Cys Single submitter ⚠
- p.Tyr52Ter Single submitter
- c.-5+762del No assertion criteria