NME4 — 37 ClinVar variants
All ClinVar germline NME4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
2 Benign · 1 Likely benign · 34 Uncertain significance
Full NME4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NME4 p.Ala187Val Uncertain significance Single submitter
- NME4 p.Arg118His Uncertain significance Single submitter
- NME4 p.Arg161Trp Uncertain significance Single submitter
- NME4 p.Arg37Trp Uncertain significance Single submitter
- NME4 p.Arg39Gln Uncertain significance Single submitter
- NME4 p.Arg52Gln Uncertain significance Single submitter
- NME4 p.Arg99Cys Uncertain significance Single submitter
- NME4 p.Asp128Asn Uncertain significance Single submitter
- NME4 p.Asp47Asn Uncertain significance Single submitter
- NME4 p.Asp56Gly Uncertain significance Single submitter
- NME4 p.Gly158Glu Uncertain significance Single submitter
- NME4 p.Gly178Arg Uncertain significance Single submitter
- NME4 p.Gly55Ala Uncertain significance Single submitter
- NME4 p.Ile124Met Uncertain significance Single submitter
- NME4 p.Leu74Val Uncertain significance Single submitter
- NME4 p.Leu97Val Uncertain significance Single submitter
- NME4 p.Ser153Arg Uncertain significance Single submitter
- NME4 p.Ser169Arg Uncertain significance Single submitter
- NME4 p.Ser170Asn Uncertain significance Single submitter
- NME4 p.Ser174Asn Uncertain significance Single submitter
- NME4 p.Ser79Asn Uncertain significance Single submitter
- NME4 p.Tyr114Asn Uncertain significance Single submitter
- NME4 p.Val117Phe Uncertain significance Single submitter
- NME4 p.Val54Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NME4 variants
Benign 2
- c.328-73G>C Multiple submitters
- p.Ala82= Multiple submitters
Likely benign 1
- p.Val80Ile Single submitter
Uncertain significance 34
- p.Ala152Thr Single submitter ⚠
- p.Ala187Val Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg51Gln Single submitter
- p.Arg52Gln Single submitter ⚠
- p.Arg52Trp Single submitter
- p.Arg64Gln Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Asp128Asn Single submitter ⚠
- p.Asp128His Single submitter
- p.Asp47Asn Single submitter ⚠
- p.Asp56Gly Single submitter ⚠
- p.Gly158Glu Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly55Ala Single submitter ⚠
- p.Ile124Met Single submitter ⚠
- p.Leu74Val Single submitter ⚠
- p.Leu97Val Single submitter ⚠
- p.Met101Ile Single submitter ⚠
- p.Met71Ile Single submitter ⚠
- p.Ser129Leu Single submitter
- p.Ser153Arg Single submitter ⚠
- p.Ser169Arg Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser174Asn Single submitter ⚠
- p.Ser79Asn Single submitter ⚠
- p.Thr67Pro Single submitter ⚠
- p.Trp35Cys Single submitter
- p.Tyr114Asn Single submitter ⚠
- p.Val117Phe Single submitter ⚠
- p.Val54Ile Single submitter ⚠