NMRAL1 — 68 ClinVar variants
All ClinVar germline NMRAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Likely benign · 65 Uncertain significance
Full NMRAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NMRAL1 p.Ala126Ser Uncertain significance Single submitter
- NMRAL1 p.Ala127Thr Uncertain significance Single submitter
- NMRAL1 p.Ala128Thr Uncertain significance Single submitter
- NMRAL1 p.Ala43Thr Uncertain significance Single submitter
- NMRAL1 p.Ala43Val Uncertain significance Single submitter
- NMRAL1 p.Ala68Thr Uncertain significance Single submitter
- NMRAL1 p.Arg141Gln Uncertain significance Single submitter
- NMRAL1 p.Arg141Trp Uncertain significance Single submitter
- NMRAL1 p.Arg255Trp Uncertain significance Single submitter
- NMRAL1 p.Arg262His Uncertain significance Single submitter
- NMRAL1 p.Arg270Leu Uncertain significance Single submitter
- NMRAL1 p.Arg40Thr Uncertain significance Single submitter
- NMRAL1 p.Asn297Thr Uncertain significance Single submitter
- NMRAL1 p.Asp238Asn Uncertain significance Single submitter
- NMRAL1 p.Asp286Glu Uncertain significance Single submitter
- NMRAL1 p.Asp99Glu Uncertain significance Single submitter
- NMRAL1 p.Gln56Arg Uncertain significance Single submitter
- NMRAL1 p.Glu222Asp Uncertain significance Single submitter
- NMRAL1 p.Glu273Asp Uncertain significance Single submitter
- NMRAL1 p.Gly132Ser Uncertain significance Single submitter
- NMRAL1 p.Gly134Ala Uncertain significance Single submitter
- NMRAL1 p.Gly294Arg Uncertain significance Single submitter
- NMRAL1 p.His129Gln Uncertain significance Single submitter
- NMRAL1 p.His162Leu Uncertain significance Single submitter
- NMRAL1 p.Ile143Thr Uncertain significance Single submitter
- NMRAL1 p.Ile212Val Uncertain significance Single submitter
- NMRAL1 p.Leu106His Uncertain significance Single submitter
- NMRAL1 p.Lys133Glu Uncertain significance Single submitter
- NMRAL1 p.Lys172Gln Uncertain significance Single submitter
- NMRAL1 p.Lys31Thr Uncertain significance Single submitter
- NMRAL1 p.Lys42Thr Uncertain significance Single submitter
- NMRAL1 p.Lys45Glu Uncertain significance Single submitter
- NMRAL1 p.Met147Val Uncertain significance Single submitter
- NMRAL1 p.Phe30Ser Uncertain significance Single submitter
- NMRAL1 p.Ser191Cys Uncertain significance Single submitter
- NMRAL1 p.Thr121Lys Uncertain significance Single submitter
- NMRAL1 p.Thr13Pro Uncertain significance Single submitter
- NMRAL1 p.Thr75Ile Uncertain significance Single submitter
- NMRAL1 p.Tyr108His Uncertain significance Single submitter
- NMRAL1 p.Tyr111Cys Uncertain significance Single submitter
- NMRAL1 p.Val110Ala Uncertain significance Single submitter
- NMRAL1 p.Val183Ile Uncertain significance Single submitter
- NMRAL1 p.Val20Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- NMRAL1 p.Arg22Cys Uncertain significance Single submitter
- NMRAL1 p.Arg270His Likely benign Single submitter
- NMRAL1 p.Asn80Ser Uncertain significance Single submitter
- NMRAL1 p.Asp170Glu Uncertain significance Single submitter
- NMRAL1 p.Asp256Gly Uncertain significance Single submitter
- NMRAL1 p.Glu223Lys Uncertain significance Single submitter
- NMRAL1 p.Gly171Arg Uncertain significance Single submitter
- NMRAL1 p.His231Asp Uncertain significance Single submitter
- NMRAL1 p.Ile143Phe Uncertain significance Single submitter
- NMRAL1 p.Ile212Phe Uncertain significance Single submitter
- NMRAL1 p.Ile212Thr Uncertain significance Single submitter
- NMRAL1 p.Leu198Phe Uncertain significance Single submitter
- NMRAL1 p.Met185Thr Uncertain significance Single submitter
- NMRAL1 p.Thr121Met Uncertain significance Single submitter
- NMRAL1 p.Val190Met Uncertain significance Single submitter
- NMRAL1 p.Val55Ala Uncertain significance Single submitter
All NMRAL1 variants
Likely benign 3
- p.Arg103His Single submitter
- p.Arg270His Single submitter ⚠
- p.Val208Ile Single submitter
Uncertain significance 65
- p.Ala126Ser Single submitter ⚠
- p.Ala127Thr Single submitter ⚠
- p.Ala128Thr Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Ala98Thr Single submitter
- p.Arg141Gln Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg151Trp Single submitter
- p.Arg22Cys Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg262His Single submitter ⚠
- p.Arg270Leu Single submitter ⚠
- p.Arg37Gln Single submitter
- p.Arg40Thr Single submitter ⚠
- p.Asn297Thr Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asp170Glu Single submitter ⚠
- p.Asp238Asn Single submitter ⚠
- p.Asp256Gly Single submitter ⚠
- p.Asp286Glu Single submitter ⚠
- p.Asp99Glu Single submitter ⚠
- p.Gln56Arg Single submitter ⚠
- p.Glu222Asp Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu273Asp Single submitter ⚠
- p.Gly113Ser Single submitter
- p.Gly132Ser Single submitter ⚠
- p.Gly134Ala Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly171Val Single submitter
- p.Gly294Arg Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.His162Leu Single submitter ⚠
- p.His231Asp Single submitter ⚠
- p.Ile143Phe Single submitter ⚠
- p.Ile143Thr Single submitter ⚠
- p.Ile212Phe Single submitter ⚠
- p.Ile212Thr Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Leu106His Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Lys133Glu Single submitter ⚠
- p.Lys172Gln Single submitter ⚠
- p.Lys31Thr Single submitter ⚠
- p.Lys42Thr Single submitter ⚠
- p.Lys45Glu Single submitter ⚠
- p.Met147Val Single submitter ⚠
- p.Met185Thr Single submitter ⚠
- p.Phe30Ser Single submitter ⚠
- p.Pro204Leu Single submitter
- p.Ser191Cys Single submitter ⚠
- p.Thr121Lys Single submitter ⚠
- p.Thr121Met Single submitter ⚠
- p.Thr13Pro Single submitter ⚠
- p.Thr216Ile Single submitter
- p.Thr75Ile Single submitter ⚠
- p.Tyr108His Single submitter ⚠
- p.Tyr111Cys Single submitter ⚠
- p.Val110Ala Single submitter ⚠
- p.Val183Ile Single submitter ⚠
- p.Val190Met Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val55Ala Single submitter ⚠