NMT1 — 31 ClinVar variants
All ClinVar germline NMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Likely benign · 30 Uncertain significance
Full NMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NMT1 p.Ala106Ser Uncertain significance Single submitter
- NMT1 p.Ala228Thr Uncertain significance Single submitter
- NMT1 p.Ala336Thr Uncertain significance Single submitter
- NMT1 p.Arg202Gln Uncertain significance Single submitter
- NMT1 p.Arg269Met Uncertain significance Single submitter
- NMT1 p.Asn389His Uncertain significance Single submitter
- NMT1 p.Gln77Lys Uncertain significance Single submitter
- NMT1 p.Gly167Asp Uncertain significance Single submitter
- NMT1 p.Gly392Arg Uncertain significance Single submitter
- NMT1 p.Ile469Val Uncertain significance Single submitter
- NMT1 p.Met435Thr Uncertain significance Single submitter
- NMT1 p.Pro208Leu Uncertain significance Single submitter
- NMT1 p.Pro48Leu Uncertain significance Single submitter
- NMT1 p.Ser73Leu Uncertain significance Single submitter
- NMT1 p.Thr332Ser Uncertain significance Single submitter
- NMT1 p.Thr354Ser Uncertain significance Single submitter
- NMT1 p.Thr363Met Uncertain significance Single submitter
- NMT1 p.Tyr376Cys Uncertain significance Single submitter
- NMT1 p.Val125Ile Uncertain significance Single submitter
- NMT1 p.Val291Ile Uncertain significance Single submitter
- NMT1 p.Val365Ile Uncertain significance Single submitter
- NMT1 p.Val79Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- NMT1 p.Leu198Trp Uncertain significance Single submitter
- NMT1 p.Lys241Met Uncertain significance Single submitter
- NMT1 p.Met435Leu Uncertain significance Single submitter
- NMT1 p.Thr174Ile Uncertain significance Single submitter
- NMT1 p.Thr402Met Uncertain significance Single submitter
- NMT1 p.Val168Met Uncertain significance Single submitter
All NMT1 variants
Likely benign 1
- p.Thr238= Single submitter
Uncertain significance 30
- p.Ala106Ser Single submitter ⚠
- p.Ala228Thr Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg269Met Single submitter ⚠
- p.Asn389His Single submitter ⚠
- p.Gln77Lys Single submitter ⚠
- p.Glu195fs Single submitter
- p.Gly167Asp Single submitter ⚠
- p.Gly392Arg Single submitter ⚠
- p.Ile469Val Single submitter ⚠
- p.Leu198Trp Single submitter ⚠
- p.Lys241Met Single submitter ⚠
- p.Met435Leu Single submitter ⚠
- p.Met435Thr Single submitter ⚠
- p.Pro208Leu Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Ser73Leu Single submitter ⚠
- p.Thr174Ile Single submitter ⚠
- p.Thr332Ser Single submitter ⚠
- p.Thr354Ser Single submitter ⚠
- p.Thr363Met Single submitter ⚠
- p.Thr402Met Single submitter ⚠
- p.Thr427Ile Single submitter
- p.Tyr376Cys Single submitter ⚠
- p.Val125Ile Single submitter ⚠
- p.Val168Met Single submitter ⚠
- p.Val291Ile Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val79Leu Single submitter ⚠