NMUR2 — 57 ClinVar variants
All ClinVar germline NMUR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Conflicting · 2 Benign · 4 Likely benign · 50 Uncertain significance
Full NMUR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NMUR2 p.Ala124Val Uncertain significance Single submitter
- NMUR2 p.Ala154Val Uncertain significance Single submitter
- NMUR2 p.Ala395Glu Uncertain significance Single submitter
- NMUR2 p.Arg108His Uncertain significance Single submitter
- NMUR2 p.Arg153Leu Uncertain significance Single submitter
- NMUR2 p.Arg162Trp Uncertain significance Single submitter
- NMUR2 p.Asn63Asp Uncertain significance Single submitter
- NMUR2 p.Asp252Asn Uncertain significance Single submitter
- NMUR2 p.Gln385Arg Uncertain significance Single submitter
- NMUR2 p.Gln72His Uncertain significance Single submitter
- NMUR2 p.Glu5Ala Uncertain significance Single submitter
- NMUR2 p.Gly118Asp Uncertain significance Single submitter
- NMUR2 p.Gly168Val Uncertain significance Single submitter
- NMUR2 p.His190Arg Uncertain significance Single submitter
- NMUR2 p.Ile61Thr Uncertain significance Single submitter
- NMUR2 p.Leu243Pro Uncertain significance Single submitter
- NMUR2 p.Leu270Pro Uncertain significance Single submitter
- NMUR2 p.Met239Leu Uncertain significance Single submitter
- NMUR2 p.Met76Arg Uncertain significance Single submitter
- NMUR2 p.Phe271Ser Uncertain significance Single submitter
- NMUR2 p.Pro111Ser Uncertain significance Single submitter
- NMUR2 p.Pro111Thr Uncertain significance Single submitter
- NMUR2 p.Pro261Thr Uncertain significance Single submitter
- NMUR2 p.Pro283Leu Uncertain significance Single submitter
- NMUR2 p.Pro324Leu Uncertain significance Single submitter
- NMUR2 p.Pro380Ser Uncertain significance Single submitter
- NMUR2 p.Ser351Pro Uncertain significance Single submitter
- NMUR2 p.Ser403Leu Uncertain significance Single submitter
- NMUR2 p.Thr123Met Uncertain significance Single submitter
- NMUR2 p.Thr375Pro Uncertain significance Single submitter
- NMUR2 p.Trp171Cys Uncertain significance Single submitter
- NMUR2 p.Val129Ala Uncertain significance Single submitter
- NMUR2 p.Val140Phe Uncertain significance Single submitter
- NMUR2 p.Val146Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- NMUR2 p.Ala132Val Uncertain significance Single submitter
- NMUR2 p.Arg333Cys Uncertain significance Single submitter
- NMUR2 p.Asn194Ser Uncertain significance Single submitter
- NMUR2 p.Asn306Lys Uncertain significance Single submitter
- NMUR2 p.His353Pro Uncertain significance Single submitter
- NMUR2 p.Phe126Ser Uncertain significance Single submitter
- NMUR2 p.Phe271Leu Uncertain significance Single submitter
- NMUR2 p.Tyr104Cys Uncertain significance Single submitter
- NMUR2 p.Val129Leu Uncertain significance Single submitter
- NMUR2 p.Val274Ile Uncertain significance Single submitter
All NMUR2 variants
Conflicting classifications of pathogenicity 1
- p.Lys155Glu Single submitter
Likely benign 4
- p.Glu368Gln Single submitter
- p.Leu93= Single submitter
- p.Phe152fs Single submitter
- p.Ser399Thr Single submitter
Uncertain significance 50
- p.Ala124Val Single submitter ⚠
- p.Ala132Val Single submitter ⚠
- p.Ala147Thr Single submitter
- p.Ala154Val Single submitter ⚠
- p.Ala395Glu Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg41Pro Single submitter
- p.Asn194Ser Single submitter ⚠
- p.Asn306Lys Single submitter ⚠
- p.Asn63Asp Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Asp287Asn Single submitter
- p.Gln385Arg Single submitter ⚠
- p.Gln72His Single submitter ⚠
- p.Glu5Ala Single submitter ⚠
- p.Gly118Asp Single submitter ⚠
- p.Gly168Val Single submitter ⚠
- p.His190Arg Single submitter ⚠
- p.His309Tyr Single submitter
- p.His353Pro Single submitter ⚠
- p.Ile61Thr Single submitter ⚠
- p.Leu243Pro Single submitter ⚠
- p.Leu270Pro Single submitter ⚠
- p.Met239Leu Single submitter ⚠
- p.Met76Arg Single submitter ⚠
- p.Phe126Ser Single submitter ⚠
- p.Phe271Leu Single submitter ⚠
- p.Phe271Ser Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro111Thr Single submitter ⚠
- p.Pro261Thr Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro380Ser Single submitter ⚠
- p.Ser201Leu Single submitter
- p.Ser351Pro Single submitter ⚠
- p.Ser403Leu Single submitter ⚠
- p.Thr123Met Single submitter ⚠
- p.Thr182Ile Single submitter
- p.Thr375Pro Single submitter ⚠
- p.Trp171Cys Single submitter ⚠
- p.Tyr104Cys Single submitter ⚠
- p.Val129Ala Single submitter ⚠
- p.Val129Leu Single submitter ⚠
- p.Val140Phe Single submitter ⚠
- p.Val146Leu Single submitter ⚠
- p.Val274Ile Single submitter ⚠