NNMT — 48 ClinVar variants
All ClinVar germline NNMT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Likely benign · 47 Uncertain significance
Full NNMT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NNMT p.Ala169Thr Uncertain significance Single submitter
- NNMT p.Ala179Ser Uncertain significance Single submitter
- NNMT p.Ala179Val Uncertain significance Single submitter
- NNMT p.Ala198Thr Uncertain significance Single submitter
- NNMT p.Arg18Gln Uncertain significance Single submitter
- NNMT p.Arg18Trp Uncertain significance Single submitter
- NNMT p.Arg218Gln Uncertain significance Single submitter
- NNMT p.Asn120Asp Uncertain significance Single submitter
- NNMT p.Cys141Phe Uncertain significance Single submitter
- NNMT p.Cys141Ser Uncertain significance Single submitter
- NNMT p.Gln89Pro Uncertain significance Single submitter
- NNMT p.Glu126Asp Uncertain significance Single submitter
- NNMT p.Glu95Gly Uncertain significance Single submitter
- NNMT p.Gly53Cys Uncertain significance Single submitter
- NNMT p.Gly56Arg Uncertain significance Single submitter
- NNMT p.Gly65Asp Uncertain significance Single submitter
- NNMT p.His14Gln Uncertain significance Single submitter
- NNMT p.His40Pro Uncertain significance Single submitter
- NNMT p.Leu117Pro Uncertain significance Single submitter
- NNMT p.Leu164Pro Uncertain significance Single submitter
- NNMT p.Leu180His Uncertain significance Single submitter
- NNMT p.Leu186Pro Uncertain significance Single submitter
- NNMT p.Leu187Arg Uncertain significance Single submitter
- NNMT p.Leu187Gln Uncertain significance Single submitter
- NNMT p.Leu38Phe Uncertain significance Single submitter
- NNMT p.Leu71Ile Uncertain significance Single submitter
- NNMT p.Lys210Thr Uncertain significance Single submitter
- NNMT p.Lys26Glu Uncertain significance Single submitter
- NNMT p.Met205Val Uncertain significance Single submitter
- NNMT p.Pro155Ser Uncertain significance Single submitter
- NNMT p.Ser212Phe Uncertain significance Single submitter
- NNMT p.Ser64Phe Uncertain significance Single submitter
- NNMT p.Thr67Ile Uncertain significance Single submitter
- NNMT p.Val82Phe Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- NNMT p.Ala257Val Uncertain significance Single submitter
- NNMT p.Arg218Trp Uncertain significance Single submitter
- NNMT p.Asn182Lys Uncertain significance Single submitter
- NNMT p.Asp172Glu Uncertain significance Single submitter
- NNMT p.Leu149Arg Uncertain significance Single submitter
- NNMT p.Lys127Glu Uncertain significance Single submitter
- NNMT p.Phe235Leu Uncertain significance Single submitter
- NNMT p.Tyr230His Uncertain significance Single submitter
- NNMT p.Val143Met Uncertain significance Single submitter
- NNMT p.Val160Met Uncertain significance Single submitter
- NNMT p.Val194Met Uncertain significance Single submitter
- NNMT p.Val237Met Uncertain significance Single submitter
All NNMT variants
Likely benign 1
- p.Val160Leu Single submitter
Uncertain significance 47
- p.Ala169Thr Single submitter ⚠
- p.Ala179Ser Single submitter ⚠
- p.Ala179Val Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala257Val Single submitter ⚠
- p.Arg18Gln Single submitter ⚠
- p.Arg18Trp Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Asn120Asp Single submitter ⚠
- p.Asn182Lys Single submitter ⚠
- p.Asp172Glu Single submitter ⚠
- p.Cys141Phe Single submitter ⚠
- p.Cys141Ser Single submitter ⚠
- p.Gln89Pro Single submitter ⚠
- p.Glu126Asp Single submitter ⚠
- p.Glu95Gly Single submitter ⚠
- p.Gly53Cys Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Gly65Asp Single submitter ⚠
- p.His14Gln Single submitter ⚠
- p.His40Pro Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu149Arg Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu180His Single submitter ⚠
- p.Leu186Pro Single submitter ⚠
- p.Leu187Arg Single submitter ⚠
- p.Leu187Gln Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Leu71Ile Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys210Thr Single submitter ⚠
- p.Lys26Glu Single submitter ⚠
- p.Met205Val Single submitter ⚠
- p.Phe235Leu Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Ser212Phe Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Thr67Ile Single submitter ⚠
- p.Tyr230His Single submitter ⚠
- p.Tyr69Cys Single submitter
- p.Val143Met Single submitter ⚠
- p.Val160Met Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val237Met Single submitter ⚠
- p.Val82Phe Single submitter ⚠