NOD1 — 163 ClinVar variants

All ClinVar germline NOD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 134 flagged for review →

6 Benign · 17 Likely benign · 140 Uncertain significance

Full NOD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 134

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 102

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All NOD1 variants

Benign 6

p.Ala574= Single submitter
p.Ala941= Single submitter
p.Arg297= Single submitter
p.Arg447His Single submitter
p.Asp372Asn Single submitter
p.Glu266Lys Single submitter

Likely benign 17

p.Arg214Gln Multiple submitters
c.377-10C>T Single submitter
p.Ala554Val Single submitter
p.Ala773= Single submitter
p.Arg405His Single submitter
p.Arg534Lys Single submitter
p.Arg605Gln Single submitter
p.Arg721Gln Single submitter
p.Gln132Lys Single submitter
p.Gln465Arg Single submitter
p.Gln877Lys Single submitter
p.Gly743Ser Single submitter
p.Pro573Leu Single submitter
p.Ser627= Single submitter
p.Ser922Asn Single submitter
p.Thr787Met Single submitter ⚠
p.Val776Ile Single submitter

Uncertain significance 140

p.Ala833Thr Multiple submitters ⚠
p.Ser16Phe Multiple submitters ⚠
p.Ala148Gly Single submitter ⚠
p.Ala279Ser Single submitter ⚠
p.Ala315Thr Single submitter ⚠
p.Ala467Thr Single submitter ⚠
p.Ala522Thr Single submitter ⚠
p.Ala52Val Single submitter ⚠
p.Ala55Thr Single submitter ⚠
p.Ala610Val Single submitter ⚠
p.Ala619Thr Single submitter ⚠
p.Ala694Pro Single submitter ⚠
p.Ala694Val Single submitter
p.Ala861Val Single submitter
p.Ala885Gly Single submitter ⚠
p.Arg223Trp Single submitter ⚠
p.Arg235His Single submitter ⚠
p.Arg237Cys Single submitter ⚠
p.Arg237His Single submitter ⚠
p.Arg247fs Single submitter
p.Arg263Trp Single submitter ⚠
p.Arg340Cys Single submitter ⚠
p.Arg344Trp Single submitter ⚠
p.Arg358Cys Single submitter ⚠
p.Arg35His Single submitter ⚠
p.Arg368Trp Single submitter ⚠
p.Arg399Gln Single submitter ⚠
p.Arg399Trp Single submitter ⚠
p.Arg444Gln Single submitter ⚠
p.Arg457Gln Single submitter ⚠
p.Arg469Gln Single submitter ⚠
p.Arg499Trp Single submitter ⚠
p.Arg575Gln Single submitter ⚠
p.Arg575Trp Single submitter ⚠
p.Arg657Cys Single submitter
p.Arg657His Single submitter ⚠
p.Arg69Cys Single submitter ⚠
p.Arg69His Single submitter ⚠
p.Arg705Trp Single submitter ⚠
p.Arg729His Single submitter ⚠
p.Arg774Ser Single submitter ⚠
p.Arg949Gln Single submitter ⚠
p.Asn171Ser Single submitter ⚠
p.Asn316Lys Single submitter ⚠
p.Asn36Thr Single submitter ⚠
p.Asn381Ser Single submitter ⚠
p.Asn589Ser Single submitter ⚠
p.Asn738Lys Single submitter ⚠
p.Asp264Val Single submitter ⚠
p.Asp300Asn Single submitter ⚠
p.Asp533Asn Single submitter ⚠
p.Asp709Gly Single submitter ⚠
p.Asp770His Single submitter ⚠
p.Asp99Asn Single submitter ⚠
p.Cys400Tyr Single submitter ⚠
p.Cys685Ser Single submitter ⚠
p.Cys692Tyr Single submitter ⚠
p.Gln194His Single submitter ⚠
p.Gln510Arg Single submitter ⚠
p.Gln538Lys Single submitter ⚠
p.Gln865Leu Single submitter ⚠
p.Glu337Lys Single submitter ⚠
p.Glu367Lys Single submitter ⚠
p.Glu503Gly Single submitter ⚠
p.Glu546Lys Single submitter ⚠
p.Glu890Val Single submitter ⚠
p.Gly285Ala Single submitter ⚠
p.Gly719Ser Single submitter ⚠
p.Gly744Glu Single submitter ⚠
p.Gly857Ala Single submitter ⚠
p.His136Arg Single submitter ⚠
p.His233Arg Single submitter ⚠
p.His277Asn Single submitter ⚠
p.His277Asp Single submitter ⚠
p.His290Gln Single submitter ⚠
p.His356Tyr Single submitter ⚠
p.His403Arg Single submitter ⚠
p.His584Gln Single submitter
p.His839Tyr Single submitter
p.Ile659Met Single submitter ⚠
p.Ile814Val Single submitter ⚠
p.Ile926Val Single submitter ⚠
p.Ile951Leu Single submitter ⚠
p.Leu254Pro Single submitter ⚠
p.Leu30Pro Single submitter ⚠
p.Leu322Val Single submitter ⚠
p.Leu475Arg Single submitter ⚠
p.Leu518Pro Single submitter ⚠
p.Leu578His Single submitter ⚠
p.Leu780Pro Single submitter ⚠
p.Leu935Arg Single submitter ⚠
p.Lys746Asn Single submitter ⚠
p.Lys746Gln Single submitter ⚠
p.Lys812Arg Single submitter ⚠
p.Lys893Glu Single submitter ⚠
p.Met164Ile Single submitter ⚠
p.Met210Val Single submitter ⚠
p.Met238Thr Single submitter ⚠
p.Phe143Leu Single submitter ⚠
p.Phe199Leu Single submitter ⚠
p.Phe515Cys Single submitter ⚠
p.Phe652Leu Single submitter ⚠
p.Pro102Leu Single submitter ⚠
p.Pro125Ser Single submitter
p.Pro310Thr Single submitter ⚠
p.Pro354Leu Single submitter ⚠
p.Pro438Leu Single submitter ⚠
p.Pro564Gln Single submitter ⚠
p.Pro609Leu Single submitter ⚠
p.Pro650Leu Single submitter ⚠
p.Pro65Ser Single submitter ⚠
p.Ser141Cys Single submitter ⚠
p.Ser16Thr Single submitter ⚠
p.Ser176Gly Single submitter ⚠
p.Ser51Leu Single submitter ⚠
p.Ser689Leu Single submitter ⚠
p.Ser77Asn Single submitter ⚠
p.Thr197Ser Single submitter ⚠
p.Thr429Ser Single submitter ⚠
p.Thr459Ile Single submitter ⚠
p.Thr537Ala Single submitter ⚠
p.Thr556Met Single submitter ⚠
p.Thr683Ile Single submitter ⚠
p.Thr843Ile Single submitter ⚠
p.Thr868Met Single submitter ⚠
p.Thr897Met Single submitter ⚠
p.Tyr147Asp Single submitter ⚠
p.Tyr159Phe Single submitter ⚠
p.Tyr260His Single submitter ⚠
p.Tyr775Phe Single submitter ⚠
p.Val144Leu Single submitter ⚠
p.Val167Ile Single submitter ⚠
p.Val206Met Single submitter ⚠
p.Val268Leu Single submitter ⚠
p.Val298Met Single submitter ⚠
p.Val450Met Single submitter ⚠
p.Val720Met Single submitter ⚠
p.Val82Leu Single submitter ⚠
p.Val884Glu Single submitter ⚠
p.Val943Gly Single submitter ⚠