NOLC1 — 122 ClinVar variants
All ClinVar germline NOLC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
4 Benign · 14 Likely benign · 104 Uncertain significance
Full NOLC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOLC1 p.Ala106Val Uncertain significance Single submitter
- NOLC1 p.Ala205Gly Uncertain significance Single submitter
- NOLC1 p.Ala250Val Uncertain significance Single submitter
- NOLC1 p.Ala256Val Uncertain significance Single submitter
- NOLC1 p.Ala297Pro Uncertain significance Single submitter
- NOLC1 p.Ala359Gly Uncertain significance Single submitter
- NOLC1 p.Ala392Val Uncertain significance Single submitter
- NOLC1 p.Ala489Thr Uncertain significance Single submitter
- NOLC1 p.Ala573Val Uncertain significance Single submitter
- NOLC1 p.Ala621Ser Uncertain significance Single submitter
- NOLC1 p.Ala621Val Uncertain significance Single submitter
- NOLC1 p.Ala640Thr Uncertain significance Single submitter
- NOLC1 p.Ala646Asp Uncertain significance Single submitter
- NOLC1 p.Ala651Ser Uncertain significance Single submitter
- NOLC1 p.Ala75Ser Uncertain significance Single submitter
- NOLC1 p.Ala78Gly Uncertain significance Single submitter
- NOLC1 p.Ala82Gly Uncertain significance Single submitter
- NOLC1 p.Arg111Gln Uncertain significance Single submitter
- NOLC1 p.Arg204Gln Uncertain significance Single submitter
- NOLC1 p.Arg586Gln Uncertain significance Single submitter
- NOLC1 p.Arg620Gly Uncertain significance Single submitter
- NOLC1 p.Arg627Gly Uncertain significance Single submitter
- NOLC1 p.Arg671Gln Uncertain significance Single submitter
- NOLC1 p.Arg679Gln Uncertain significance Single submitter
- NOLC1 p.Asn46Ser Uncertain significance Single submitter
- NOLC1 p.Asn556Asp Uncertain significance Single submitter
- NOLC1 p.Asp134Asn Uncertain significance Single submitter
- NOLC1 p.Asp134Gly Uncertain significance Single submitter
- NOLC1 p.Asp140Asn Uncertain significance Single submitter
- NOLC1 p.Asp364Glu Uncertain significance Single submitter
- NOLC1 p.Asp524Ala Uncertain significance Single submitter
- NOLC1 p.Asp641Gly Uncertain significance Single submitter
- NOLC1 p.Glu139Gln Uncertain significance Single submitter
- NOLC1 p.Glu320Gly Uncertain significance Single submitter
- NOLC1 p.Glu375Val Uncertain significance Single submitter
- NOLC1 p.Glu565Val Uncertain significance Single submitter
- NOLC1 p.Glu566Gly Uncertain significance Single submitter
- NOLC1 p.Glu594Val Uncertain significance Single submitter
- NOLC1 p.Glu656Asp Uncertain significance Single submitter
- NOLC1 p.Glu673Lys Uncertain significance Single submitter
- NOLC1 p.Gly113Asp Uncertain significance Single submitter
- NOLC1 p.Gly287Val Uncertain significance Single submitter
- NOLC1 p.Gly537Val Uncertain significance Single submitter
- NOLC1 p.Gly680Asp Uncertain significance Single submitter
- NOLC1 p.Ile187Met Uncertain significance Single submitter
- NOLC1 p.Ile687Val Uncertain significance Single submitter
- NOLC1 p.Leu457Val Uncertain significance Single submitter
- NOLC1 p.Leu583Ser Uncertain significance Single submitter
- NOLC1 p.Lys142Asn Uncertain significance Single submitter
- NOLC1 p.Lys280Asn Uncertain significance Single submitter
- NOLC1 p.Lys283Arg Uncertain significance Single submitter
- NOLC1 p.Lys338Arg Uncertain significance Single submitter
- NOLC1 p.Lys420Arg Uncertain significance Single submitter
- NOLC1 p.Lys448Arg Uncertain significance Single submitter
- NOLC1 p.Lys452Gln Uncertain significance Single submitter
- NOLC1 p.Lys460Arg Uncertain significance Single submitter
- NOLC1 p.Lys513Arg Uncertain significance Single submitter
- NOLC1 p.Lys572Arg Uncertain significance Single submitter
- NOLC1 p.Lys619Glu Uncertain significance Single submitter
- NOLC1 p.Pro116Ser Uncertain significance Single submitter
- NOLC1 p.Pro189Ser Uncertain significance Single submitter
- NOLC1 p.Pro189Thr Uncertain significance Single submitter
- NOLC1 p.Pro199Ser Uncertain significance Single submitter
- NOLC1 p.Pro253Ala Uncertain significance Single submitter
- NOLC1 p.Pro260Ala Uncertain significance Single submitter
- NOLC1 p.Pro260Leu Uncertain significance Single submitter
- NOLC1 p.Pro294Leu Uncertain significance Single submitter
- NOLC1 p.Pro299Arg Uncertain significance Single submitter
- NOLC1 p.Pro339Thr Uncertain significance Single submitter
- NOLC1 p.Pro494Thr Uncertain significance Single submitter
- NOLC1 p.Pro539Thr Uncertain significance Single submitter
- NOLC1 p.Pro608Leu Uncertain significance Single submitter
- NOLC1 p.Ser475Gly Uncertain significance Single submitter
- NOLC1 p.Ser48Phe Uncertain significance Single submitter
- NOLC1 p.Ser508Phe Uncertain significance Single submitter
- NOLC1 p.Ser519Asn Uncertain significance Single submitter
- NOLC1 p.Ser55Thr Uncertain significance Single submitter
- NOLC1 p.Ser578Ala Uncertain significance Single submitter
- NOLC1 p.Ser681Gly Uncertain significance Single submitter
- NOLC1 p.Ser688Thr Uncertain significance Single submitter
- NOLC1 p.Thr349Ser Uncertain significance Single submitter
- NOLC1 p.Trp654Arg Uncertain significance Single submitter
- NOLC1 p.Val190Leu Uncertain significance Single submitter
- NOLC1 p.Val393Leu Uncertain significance Single submitter
- NOLC1 p.Val575Met Uncertain significance Single submitter
- NOLC1 p.Val576Ile Uncertain significance Single submitter
- NOLC1 p.Val689Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- NOLC1 p.Arg586Trp Uncertain significance Single submitter
- NOLC1 p.Glu178Gln Uncertain significance Single submitter
- NOLC1 p.Glu434Lys Uncertain significance Single submitter
- NOLC1 p.Glu630Gly Uncertain significance Single submitter
- NOLC1 p.Glu92Lys Uncertain significance Single submitter
- NOLC1 p.Gly500Cys Uncertain significance Single submitter
- NOLC1 p.Gly652Arg Uncertain significance Single submitter
- NOLC1 p.Lys505Glu Uncertain significance Single submitter
- NOLC1 p.Pro244Arg Uncertain significance Single submitter
- NOLC1 p.Ser126Cys Uncertain significance Single submitter
- NOLC1 p.Ser432Phe Uncertain significance Single submitter
- NOLC1 p.Ser477Ile Uncertain significance Single submitter
- NOLC1 p.Ser486Cys Uncertain significance Single submitter
- NOLC1 p.Ser84Thr Uncertain significance Single submitter
- NOLC1 p.Ser91Arg Uncertain significance Single submitter
All NOLC1 variants
Benign 4
- p.Gly412Val Multiple submitters
- p.Lys315= Multiple submitters
- p.Ser637= Multiple submitters
- p.Ser580Leu Single submitter
Likely benign 14
- c.1099+10A>G Multiple submitters
- c.1849-9C>T Single submitter
- p.Ala157Val Single submitter
- p.Ala405Thr Single submitter
- p.Ala449Val Single submitter
- p.Arg262Gln Single submitter
- p.Arg683Gln Single submitter
- p.Asp524Asn Single submitter
- p.Glu336= Single submitter
- p.Gly113Ser Single submitter
- p.Lys615= Single submitter
- p.Ser219= Single submitter
- p.Thr258Ala Single submitter
- p.Thr418Met Single submitter
Uncertain significance 104
- p.Ala106Val Single submitter ⚠
- p.Ala205Gly Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Ala297Pro Single submitter ⚠
- p.Ala359Gly Single submitter ⚠
- p.Ala392Val Single submitter ⚠
- p.Ala489Thr Single submitter ⚠
- p.Ala573Val Single submitter ⚠
- p.Ala621Ser Single submitter ⚠
- p.Ala621Val Single submitter ⚠
- p.Ala640Thr Single submitter ⚠
- p.Ala646Asp Single submitter ⚠
- p.Ala651Ser Single submitter ⚠
- p.Ala75Ser Single submitter ⚠
- p.Ala78Gly Single submitter ⚠
- p.Ala82Gly Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg586Gln Single submitter ⚠
- p.Arg586Trp Single submitter ⚠
- p.Arg620Gly Single submitter ⚠
- p.Arg627Gly Single submitter ⚠
- p.Arg671Gln Single submitter ⚠
- p.Arg679Gln Single submitter ⚠
- p.Asn46Ser Single submitter ⚠
- p.Asn556Asp Single submitter ⚠
- p.Asn692Ser Single submitter
- p.Asp134Asn Single submitter ⚠
- p.Asp134Gly Single submitter ⚠
- p.Asp140Asn Single submitter ⚠
- p.Asp364Glu Single submitter ⚠
- p.Asp524Ala Single submitter ⚠
- p.Asp641Gly Single submitter ⚠
- p.Glu139Gln Single submitter ⚠
- p.Glu178Gln Single submitter ⚠
- p.Glu320Gly Single submitter ⚠
- p.Glu375Val Single submitter ⚠
- p.Glu434Lys Single submitter ⚠
- p.Glu565Val Single submitter ⚠
- p.Glu566Gly Single submitter ⚠
- p.Glu594Val Single submitter ⚠
- p.Glu630Gly Single submitter ⚠
- p.Glu656Asp Single submitter ⚠
- p.Glu673Lys Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly113Asp Single submitter ⚠
- p.Gly287Val Single submitter ⚠
- p.Gly500Cys Single submitter ⚠
- p.Gly537Val Single submitter ⚠
- p.Gly652Arg Single submitter ⚠
- p.Gly680Asp Single submitter ⚠
- p.Ile187Met Single submitter ⚠
- p.Ile687Val Single submitter ⚠
- p.Leu457Val Single submitter ⚠
- p.Leu583Ser Single submitter ⚠
- p.Lys142Asn Single submitter ⚠
- p.Lys280Asn Single submitter ⚠
- p.Lys283Arg Single submitter ⚠
- p.Lys338Arg Single submitter ⚠
- p.Lys420Arg Single submitter ⚠
- p.Lys448Arg Single submitter ⚠
- p.Lys452Gln Single submitter ⚠
- p.Lys460Arg Single submitter ⚠
- p.Lys505Glu Single submitter ⚠
- p.Lys513Arg Single submitter ⚠
- p.Lys572Arg Single submitter ⚠
- p.Lys619Glu Single submitter ⚠
- p.Lys668Arg Single submitter
- p.Pro116Ser Single submitter ⚠
- p.Pro189Ser Single submitter ⚠
- p.Pro189Thr Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro244Arg Single submitter ⚠
- p.Pro253Ala Single submitter ⚠
- p.Pro260Ala Single submitter ⚠
- p.Pro260Leu Single submitter ⚠
- p.Pro294Leu Single submitter ⚠
- p.Pro299Arg Single submitter ⚠
- p.Pro339Thr Single submitter ⚠
- p.Pro494Thr Single submitter ⚠
- p.Pro539Thr Single submitter ⚠
- p.Pro608Leu Single submitter ⚠
- p.Ser126Cys Single submitter ⚠
- p.Ser432Phe Single submitter ⚠
- p.Ser475Gly Single submitter ⚠
- p.Ser477Ile Single submitter ⚠
- p.Ser486Cys Single submitter ⚠
- p.Ser48Phe Single submitter ⚠
- p.Ser508Phe Single submitter ⚠
- p.Ser519Asn Single submitter ⚠
- p.Ser55Thr Single submitter ⚠
- p.Ser578Ala Single submitter ⚠
- p.Ser681Gly Single submitter ⚠
- p.Ser688Thr Single submitter ⚠
- p.Ser84Thr Single submitter ⚠
- p.Ser91Arg Single submitter ⚠
- p.Thr349Ser Single submitter ⚠
- p.Trp654Arg Single submitter ⚠
- p.Val190Leu Single submitter ⚠
- p.Val393Leu Single submitter ⚠
- p.Val575Met Single submitter ⚠
- p.Val576Ile Single submitter ⚠
- p.Val689Leu Single submitter ⚠