NOP2 — 133 ClinVar variants
All ClinVar germline NOP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
7 Benign · 10 Likely benign · 116 Uncertain significance
Full NOP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 93
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOP2 p.Ala158Val Uncertain significance Single submitter
- NOP2 p.Ala18Val Uncertain significance Single submitter
- NOP2 p.Ala381Glu Uncertain significance Single submitter
- NOP2 p.Ala52Thr Uncertain significance Single submitter
- NOP2 p.Ala645Val Uncertain significance Single submitter
- NOP2 p.Ala672Thr Uncertain significance Single submitter
- NOP2 p.Ala738Gly Uncertain significance Single submitter
- NOP2 p.Arg106His Uncertain significance Single submitter
- NOP2 p.Arg251Cys Uncertain significance Single submitter
- NOP2 p.Arg251His Uncertain significance Single submitter
- NOP2 p.Arg251Leu Uncertain significance Single submitter
- NOP2 p.Arg313Gln Uncertain significance Single submitter
- NOP2 p.Arg322Gln Uncertain significance Single submitter
- NOP2 p.Arg331Cys Uncertain significance Single submitter
- NOP2 p.Arg431Trp Uncertain significance Single submitter
- NOP2 p.Arg46Cys Uncertain significance Single submitter
- NOP2 p.Arg48Gln Uncertain significance Single submitter
- NOP2 p.Arg538Gln Uncertain significance Single submitter
- NOP2 p.Arg555Gln Uncertain significance Single submitter
- NOP2 p.Arg55Thr Uncertain significance Single submitter
- NOP2 p.Arg564Cys Uncertain significance Single submitter
- NOP2 p.Arg564His Uncertain significance Single submitter
- NOP2 p.Arg792Cys Uncertain significance Single submitter
- NOP2 p.Arg792His Uncertain significance Single submitter
- NOP2 p.Arg804Ser Uncertain significance Single submitter
- NOP2 p.Asn213Ser Uncertain significance Single submitter
- NOP2 p.Asn418Ser Uncertain significance Single submitter
- NOP2 p.Asn503Ser Uncertain significance Single submitter
- NOP2 p.Asn65Tyr Uncertain significance Single submitter
- NOP2 p.Asn774Lys Uncertain significance Single submitter
- NOP2 p.Asp137Asn Uncertain significance Single submitter
- NOP2 p.Asp187Asn Uncertain significance Single submitter
- NOP2 p.Asp245Asn Uncertain significance Single submitter
- NOP2 p.Asp37Glu Uncertain significance Single submitter
- NOP2 p.Asp724Glu Uncertain significance Single submitter
- NOP2 p.Asp775Asn Uncertain significance Single submitter
- NOP2 p.Gln169His Uncertain significance Single submitter
- NOP2 p.Gln232Glu Uncertain significance Single submitter
- NOP2 p.Gln737Arg Uncertain significance Single submitter
- NOP2 p.Gln737Glu Uncertain significance Single submitter
- NOP2 p.Glu135Lys Uncertain significance Single submitter
- NOP2 p.Glu38Lys Uncertain significance Single submitter
- NOP2 p.Glu493Gly Uncertain significance Single submitter
- NOP2 p.Glu687Lys Uncertain significance Single submitter
- NOP2 p.Gly209Ala Uncertain significance Single submitter
- NOP2 p.Gly628Arg Uncertain significance Single submitter
- NOP2 p.Gly696Arg Uncertain significance Single submitter
- NOP2 p.Gly90Asp Uncertain significance Single submitter
- NOP2 p.His430Arg Uncertain significance Single submitter
- NOP2 p.Ile178Asn Uncertain significance Single submitter
- NOP2 p.Leu368Pro Uncertain significance Single submitter
- NOP2 p.Leu609Val Uncertain significance Single submitter
- NOP2 p.Leu73Ser Uncertain significance Single submitter
- NOP2 p.Leu740Val Uncertain significance Single submitter
- NOP2 p.Lys471Arg Uncertain significance Single submitter
- NOP2 p.Lys53Arg Uncertain significance Single submitter
- NOP2 p.Lys721Asn Uncertain significance Single submitter
- NOP2 p.Lys800Gln Uncertain significance Single submitter
- NOP2 p.Lys800Thr Uncertain significance Single submitter
- NOP2 p.Met125Ile Uncertain significance Single submitter
- NOP2 p.Met125Thr Uncertain significance Single submitter
- NOP2 p.Met576Val Uncertain significance Single submitter
- NOP2 p.Phe300Cys Uncertain significance Single submitter
- NOP2 p.Phe647Tyr Uncertain significance Single submitter
- NOP2 p.Phe770Leu Uncertain significance Single submitter
- NOP2 p.Pro201Ala Uncertain significance Single submitter
- NOP2 p.Pro218Leu Uncertain significance Single submitter
- NOP2 p.Pro218Ser Uncertain significance Single submitter
- NOP2 p.Pro222Leu Uncertain significance Single submitter
- NOP2 p.Pro337His Uncertain significance Single submitter
- NOP2 p.Pro592Ser Uncertain significance Single submitter
- NOP2 p.Pro62Arg Uncertain significance Single submitter
- NOP2 p.Pro719Ser Uncertain significance Single submitter
- NOP2 p.Pro733Ser Uncertain significance Single submitter
- NOP2 p.Pro780Arg Uncertain significance Single submitter
- NOP2 p.Pro78Ser Uncertain significance Single submitter
- NOP2 p.Pro94Leu Uncertain significance Single submitter
- NOP2 p.Ser150Thr Uncertain significance Single submitter
- NOP2 p.Ser279Phe Uncertain significance Single submitter
- NOP2 p.Ser295Ala Uncertain significance Single submitter
- NOP2 p.Ser620Arg Uncertain significance Single submitter
- NOP2 p.Ser675Ile Uncertain significance Single submitter
- NOP2 p.Ser707Cys Uncertain significance Single submitter
- NOP2 p.Ser732Pro Uncertain significance Single submitter
- NOP2 p.Thr725Ile Uncertain significance Single submitter
- NOP2 p.Thr736Ile Uncertain significance Single submitter
- NOP2 p.Thr736Ser Uncertain significance Single submitter
- NOP2 p.Thr8Lys Uncertain significance Single submitter
- NOP2 p.Thr8Ser Uncertain significance Single submitter
- NOP2 p.Tyr280Cys Uncertain significance Single submitter
- NOP2 p.Tyr366Cys Uncertain significance Single submitter
- NOP2 p.Val220Met Uncertain significance Single submitter
- NOP2 p.Val426Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- NOP2 p.Arg106Cys Uncertain significance Single submitter
- NOP2 p.Arg167Trp Uncertain significance Single submitter
- NOP2 p.Arg242Gln Uncertain significance Single submitter
- NOP2 p.Arg387Gln Uncertain significance Single submitter
- NOP2 p.Arg387Trp Uncertain significance Single submitter
- NOP2 p.Asn334His Uncertain significance Single submitter
- NOP2 p.Asn415Ser Uncertain significance Single submitter
- NOP2 p.Glu186Lys Uncertain significance Single submitter
- NOP2 p.Gly13Ala Uncertain significance Single submitter
- NOP2 p.Leu291Phe Uncertain significance Single submitter
- NOP2 p.Leu335Val Uncertain significance Single submitter
- NOP2 p.Lys407Gln Uncertain significance Single submitter
- NOP2 p.Phe283Leu Uncertain significance Single submitter
- NOP2 p.Pro234Ala Uncertain significance Single submitter
- NOP2 p.Pro234Ser Uncertain significance Single submitter
- NOP2 p.Pro376Ala Uncertain significance Single submitter
- NOP2 p.Ser96Cys Uncertain significance Single submitter
- NOP2 p.Val347Leu Uncertain significance Single submitter
All NOP2 variants
Benign 7
- p.Ala158Thr Multiple submitters
- p.Arg701Gln Multiple submitters
- p.Leu267= Multiple submitters
- p.Thr140Met Multiple submitters
- p.Trp180Cys Multiple submitters
- c.1560+8C>T Single submitter
- p.Ser786fs Single submitter
Likely benign 10
- c.475-246G>A Single submitter
- c.475-261A>G Single submitter
- c.475-291G>A Single submitter
- p.Ala171Val Single submitter
- p.Arg172Gln Single submitter
- p.Gln726Glu Single submitter
- p.Leu650Pro Single submitter
- p.Leu740Pro Single submitter
- p.Lys627Arg Single submitter
- p.Val310Ile Single submitter
Uncertain significance 116
- p.Ala158Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala303Val Single submitter
- p.Ala381Glu Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala645Val Single submitter ⚠
- p.Ala672Thr Single submitter ⚠
- p.Ala738Gly Single submitter ⚠
- p.Arg106Cys Single submitter ⚠
- p.Arg106His Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg251Cys Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Arg251Leu Single submitter ⚠
- p.Arg257Trp Single submitter
- p.Arg313Gln Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Arg331Cys Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg431Trp Single submitter ⚠
- p.Arg46Cys Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg538Gly Single submitter
- p.Arg555Gln Single submitter ⚠
- p.Arg55Thr Single submitter ⚠
- p.Arg564Cys Single submitter ⚠
- p.Arg564His Single submitter ⚠
- p.Arg792Cys Single submitter ⚠
- p.Arg792His Single submitter ⚠
- p.Arg804Ser Single submitter ⚠
- p.Asn213Ser Single submitter ⚠
- p.Asn334His Single submitter ⚠
- p.Asn415Ser Single submitter ⚠
- p.Asn418Ser Single submitter ⚠
- p.Asn503Ser Single submitter ⚠
- p.Asn589Tyr Single submitter
- p.Asn65Tyr Single submitter ⚠
- p.Asn774Lys Single submitter ⚠
- p.Asp137Asn Single submitter ⚠
- p.Asp187Asn Single submitter ⚠
- p.Asp245Asn Single submitter ⚠
- p.Asp37Glu Single submitter ⚠
- p.Asp724Glu Single submitter ⚠
- p.Asp775Asn Single submitter ⚠
- p.Gln169His Single submitter ⚠
- p.Gln232Glu Single submitter ⚠
- p.Gln737Arg Single submitter ⚠
- p.Gln737Glu Single submitter ⚠
- p.Glu135Lys Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu493Gly Single submitter ⚠
- p.Glu687Lys Single submitter ⚠
- p.Gly13Ala Single submitter ⚠
- p.Gly209Ala Single submitter ⚠
- p.Gly628Arg Single submitter ⚠
- p.Gly696Arg Single submitter ⚠
- p.Gly90Asp Single submitter ⚠
- p.His430Arg Single submitter ⚠
- p.Ile178Asn Single submitter ⚠
- p.Leu291Phe Single submitter ⚠
- p.Leu335Val Single submitter ⚠
- p.Leu368Pro Single submitter ⚠
- p.Leu609Val Single submitter ⚠
- p.Leu73Ser Single submitter ⚠
- p.Leu740Val Single submitter ⚠
- p.Lys407Gln Single submitter ⚠
- p.Lys471Arg Single submitter ⚠
- p.Lys53Arg Single submitter ⚠
- p.Lys721Asn Single submitter ⚠
- p.Lys800Gln Single submitter ⚠
- p.Lys800Thr Single submitter ⚠
- p.Met125Ile Single submitter ⚠
- p.Met125Thr Single submitter ⚠
- p.Met576Val Single submitter ⚠
- p.Phe283Leu Single submitter ⚠
- p.Phe300Cys Single submitter ⚠
- p.Phe647Tyr Single submitter ⚠
- p.Phe770Leu Single submitter ⚠
- p.Pro201Ala Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Pro218Ser Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Pro234Ala Single submitter ⚠
- p.Pro234Ser Single submitter ⚠
- p.Pro337His Single submitter ⚠
- p.Pro359Ala Single submitter
- p.Pro376Ala Single submitter ⚠
- p.Pro592Ser Single submitter ⚠
- p.Pro62Arg Single submitter ⚠
- p.Pro719Ser Single submitter ⚠
- p.Pro733Ser Single submitter ⚠
- p.Pro780Arg Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser150Thr Single submitter ⚠
- p.Ser279Phe Single submitter ⚠
- p.Ser295Ala Single submitter ⚠
- p.Ser620Arg Single submitter ⚠
- p.Ser675Ile Single submitter ⚠
- p.Ser707Cys Single submitter ⚠
- p.Ser732Pro Single submitter ⚠
- p.Ser96Cys Single submitter ⚠
- p.Thr725Ile Single submitter ⚠
- p.Thr736Ile Single submitter ⚠
- p.Thr736Ser Single submitter ⚠
- p.Thr8Lys Single submitter ⚠
- p.Thr8Ser Single submitter ⚠
- p.Tyr280Cys Single submitter ⚠
- p.Tyr366Cys Single submitter ⚠
- p.Val220Met Single submitter ⚠
- p.Val347Leu Single submitter ⚠
- p.Val426Ala Single submitter ⚠