NOP58 — 56 ClinVar variants
All ClinVar germline NOP58 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
56 Uncertain significance
Full NOP58 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOP58 p.Ala344Val Uncertain significance Single submitter
- NOP58 p.Ala389Ser Uncertain significance Single submitter
- NOP58 p.Ala412Thr Uncertain significance Single submitter
- NOP58 p.Ala62Ser Uncertain significance Single submitter
- NOP58 p.Arg133Leu Uncertain significance Single submitter
- NOP58 p.Arg333Gly Uncertain significance Single submitter
- NOP58 p.Arg401Lys Uncertain significance Single submitter
- NOP58 p.Arg490Gly Uncertain significance Single submitter
- NOP58 p.Asn113Ser Uncertain significance Single submitter
- NOP58 p.Asn285Ser Uncertain significance Single submitter
- NOP58 p.Asn69Ser Uncertain significance Single submitter
- NOP58 p.Asp171Tyr Uncertain significance Single submitter
- NOP58 p.Asp213Asn Uncertain significance Single submitter
- NOP58 p.Asp373Asn Uncertain significance Single submitter
- NOP58 p.Asp452Glu Uncertain significance Single submitter
- NOP58 p.Asp52His Uncertain significance Single submitter
- NOP58 p.Cys439Arg Uncertain significance Single submitter
- NOP58 p.Glu131Lys Uncertain significance Single submitter
- NOP58 p.Glu82Ala Uncertain significance Single submitter
- NOP58 p.Gly129Ala Uncertain significance Single submitter
- NOP58 p.His343Pro Uncertain significance Single submitter
- NOP58 p.Ile41Leu Uncertain significance Single submitter
- NOP58 p.Ile41Val Uncertain significance Single submitter
- NOP58 p.Ile496Ser Uncertain significance Single submitter
- NOP58 p.Leu222Phe Uncertain significance Single submitter
- NOP58 p.Leu346Phe Uncertain significance Single submitter
- NOP58 p.Leu398Ser Uncertain significance Single submitter
- NOP58 p.Leu44Arg Uncertain significance Single submitter
- NOP58 p.Lys196Asn Uncertain significance Single submitter
- NOP58 p.Lys206Arg Uncertain significance Single submitter
- NOP58 p.Lys221Asn Uncertain significance Single submitter
- NOP58 p.Lys461Arg Uncertain significance Single submitter
- NOP58 p.Lys517Glu Uncertain significance Single submitter
- NOP58 p.Lys93Glu Uncertain significance Single submitter
- NOP58 p.Met383Val Uncertain significance Single submitter
- NOP58 p.Pro86Gln Uncertain significance Single submitter
- NOP58 p.Ser304Cys Uncertain significance Single submitter
- NOP58 p.Thr397Ser Uncertain significance Single submitter
- NOP58 p.Thr61Ile Uncertain significance Single submitter
- NOP58 p.Val316Ile Uncertain significance Single submitter
- NOP58 p.Val484Met Uncertain significance Single submitter
- NOP58 p.Val9Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- NOP58 p.Ala281Thr Uncertain significance Single submitter
- NOP58 p.Ala389Val Uncertain significance Single submitter
- NOP58 p.Glu266Lys Uncertain significance Single submitter
- NOP58 p.Lys418Asn Uncertain significance Single submitter
- NOP58 p.Met361Ile Uncertain significance Single submitter
- NOP58 p.Phe375Leu Uncertain significance Single submitter
- NOP58 p.Pro506Arg Uncertain significance Single submitter
- NOP58 p.Ser265Cys Uncertain significance Single submitter
- NOP58 p.Ser440Cys Uncertain significance Single submitter
- NOP58 p.Tyr419Asn Uncertain significance Single submitter
- NOP58 p.Val261Ala Uncertain significance Single submitter
All NOP58 variants
Uncertain significance 56
- p.Ala232del Single submitter
- p.Ala237Val Single submitter
- p.Ala281Thr Single submitter ⚠
- p.Ala344Val Single submitter ⚠
- p.Ala389Ser Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala62Ser Single submitter ⚠
- p.Arg133Leu Single submitter ⚠
- p.Arg333Gly Single submitter ⚠
- p.Arg401Lys Single submitter ⚠
- p.Arg490Gly Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asn285Ser Single submitter ⚠
- p.Asn69Ser Single submitter ⚠
- p.Asp171Tyr Single submitter ⚠
- p.Asp213Asn Single submitter ⚠
- p.Asp373Asn Single submitter ⚠
- p.Asp452Glu Single submitter ⚠
- p.Asp52His Single submitter ⚠
- p.Cys439Arg Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Glu82Ala Single submitter ⚠
- p.Gly129Ala Single submitter ⚠
- p.His343Pro Single submitter ⚠
- p.Ile41Leu Single submitter ⚠
- p.Ile41Val Single submitter ⚠
- p.Ile496Ser Single submitter ⚠
- p.Leu222Phe Single submitter ⚠
- p.Leu346Phe Single submitter ⚠
- p.Leu398Ser Single submitter ⚠
- p.Leu44Arg Single submitter ⚠
- p.Lys196Asn Single submitter ⚠
- p.Lys206Arg Single submitter ⚠
- p.Lys210Asn Single submitter
- p.Lys221Asn Single submitter ⚠
- p.Lys418Asn Single submitter ⚠
- p.Lys461Arg Single submitter ⚠
- p.Lys517Glu Single submitter ⚠
- p.Lys93Glu Single submitter ⚠
- p.Met361Ile Single submitter ⚠
- p.Met383Val Single submitter ⚠
- p.Phe375Leu Single submitter ⚠
- p.Pro506Arg Single submitter ⚠
- p.Pro86Gln Single submitter ⚠
- p.Ser265Cys Single submitter ⚠
- p.Ser304Cys Single submitter ⚠
- p.Ser440Cys Single submitter ⚠
- p.Thr397Ser Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Tyr419Asn Single submitter ⚠
- p.Val261Ala Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Val484Met Single submitter ⚠
- p.Val9Leu Single submitter ⚠