Sugi Variant

Sugi Variant/NOS3

NOS3 — 221 ClinVar variants

All ClinVar germline NOS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 133 flagged for review →

2 Likely pathogenic · 3 Conflicting · 42 Benign · 3 Benign/Likely benign · 36 Likely benign · 135 Uncertain significance

Full NOS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 133

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All NOS3 variants

Likely pathogenic 2

Conflicting classifications of pathogenicity 3

Benign 42

Benign/Likely benign 3

Likely benign 36

Uncertain significance 135