NOX4 — 81 ClinVar variants
All ClinVar germline NOX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
4 Benign · 5 Likely benign · 72 Uncertain significance
Full NOX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOX4 p.Ala10Thr Uncertain significance Single submitter
- NOX4 p.Ala333Thr Uncertain significance Single submitter
- NOX4 p.Arg231Gln Uncertain significance Single submitter
- NOX4 p.Arg325Gln Uncertain significance Single submitter
- NOX4 p.Arg334Lys Uncertain significance Single submitter
- NOX4 p.Arg6Lys Uncertain significance Single submitter
- NOX4 p.Asn230Ser Uncertain significance Single submitter
- NOX4 p.Asp137Gly Uncertain significance Single submitter
- NOX4 p.Asp150Val Uncertain significance Single submitter
- NOX4 p.Asp447Glu Uncertain significance Single submitter
- NOX4 p.Cys55Arg Uncertain significance Single submitter
- NOX4 p.Gln87Arg Uncertain significance Single submitter
- NOX4 p.Glu297Lys Uncertain significance Single submitter
- NOX4 p.Gly53Glu Uncertain significance Single submitter
- NOX4 p.Ile106Met Uncertain significance Single submitter
- NOX4 p.Ile269Leu Uncertain significance Single submitter
- NOX4 p.Ile324Asn Uncertain significance Single submitter
- NOX4 p.Ile441Val Uncertain significance Single submitter
- NOX4 p.Leu171Pro Uncertain significance Single submitter
- NOX4 p.Leu206Phe Uncertain significance Single submitter
- NOX4 p.Leu23Val Uncertain significance Single submitter
- NOX4 p.Leu291Trp Uncertain significance Single submitter
- NOX4 p.Leu457Pro Uncertain significance Single submitter
- NOX4 p.Lys328Thr Uncertain significance Single submitter
- NOX4 p.Met315Val Uncertain significance Single submitter
- NOX4 p.Met322Thr Uncertain significance Single submitter
- NOX4 p.Phe104Cys Uncertain significance Single submitter
- NOX4 p.Pro250Thr Uncertain significance Single submitter
- NOX4 p.Pro258Leu Uncertain significance Single submitter
- NOX4 p.Pro74Ser Uncertain significance Single submitter
- NOX4 p.Pro90Arg Uncertain significance Single submitter
- NOX4 p.Ser288Ala Uncertain significance Single submitter
- NOX4 p.Ser316Asn Uncertain significance Single submitter
- NOX4 p.Ser401Pro Uncertain significance Single submitter
- NOX4 p.Ser401Tyr Uncertain significance Single submitter
- NOX4 p.Ser57Asn Uncertain significance Single submitter
- NOX4 p.Thr193Ile Uncertain significance Single submitter
- NOX4 p.Thr568Arg Uncertain significance Single submitter
- NOX4 p.Thr78Ala Uncertain significance Single submitter
- NOX4 p.Trp286Cys Uncertain significance Single submitter
- NOX4 p.Tyr423Cys Uncertain significance Single submitter
- NOX4 p.Val118Met Uncertain significance Single submitter
- NOX4 p.Val168Ala Uncertain significance Single submitter
- NOX4 p.Val321Ile Uncertain significance Single submitter
- NOX4 p.Val462Ile Uncertain significance Single submitter
- NOX4 p.Val492Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- NOX4 p.Arg304Trp Uncertain significance Single submitter
- NOX4 p.Arg334Ile Uncertain significance Single submitter
- NOX4 p.Arg523Cys Uncertain significance Single submitter
- NOX4 p.Glu42Asp Uncertain significance Single submitter
- NOX4 p.Gly368Arg Uncertain significance Single submitter
- NOX4 p.Leu421Gln Uncertain significance Single submitter
- NOX4 p.Leu442Val Uncertain significance Single submitter
- NOX4 p.Leu559Arg Uncertain significance Single submitter
- NOX4 p.Lys15Glu Uncertain significance Single submitter
- NOX4 p.Lys214Arg Uncertain significance Single submitter
- NOX4 p.Lys214Asn Uncertain significance Single submitter
- NOX4 p.Lys406Glu Uncertain significance Single submitter
- NOX4 p.Phe156Ile Uncertain significance Single submitter
- NOX4 p.Phe172Leu Uncertain significance Single submitter
- NOX4 p.Phe459Ile Uncertain significance Single submitter
- NOX4 p.Phe459Leu Uncertain significance Single submitter
- NOX4 p.Ser313Leu Uncertain significance Single submitter
- NOX4 p.Ser499Gly Uncertain significance Single submitter
- NOX4 p.Thr361Ala Uncertain significance Single submitter
- NOX4 p.Tyr338His Uncertain significance Single submitter
- NOX4 p.Tyr491Cys Uncertain significance Single submitter
- NOX4 p.Val165Phe Uncertain significance Single submitter
- NOX4 p.Val170Met Uncertain significance Single submitter
- NOX4 p.Val346Ile Uncertain significance Single submitter
- NOX4 p.Val462Leu Uncertain significance Single submitter
All NOX4 variants
Benign 4
- c.1218-6C>T Multiple submitters
- p.Arg470Cys Multiple submitters
- c.57+224_57+226dup Single submitter
- p.Ala296= Single submitter
Likely benign 5
- p.Arg95= Multiple submitters
- p.Leu97Phe Multiple submitters
- p.Pro224= Multiple submitters
- p.His44Tyr Single submitter
- p.Met271Val Single submitter
Uncertain significance 72
- p.Ala10Thr Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg304Trp Single submitter ⚠
- p.Arg325Gln Single submitter ⚠
- p.Arg334Ile Single submitter ⚠
- p.Arg334Lys Single submitter ⚠
- p.Arg523Cys Single submitter ⚠
- p.Arg6Lys Single submitter ⚠
- p.Asn230Ser Single submitter ⚠
- p.Asp137Gly Single submitter ⚠
- p.Asp150Val Single submitter ⚠
- p.Asp447Glu Single submitter ⚠
- p.Cys55Arg Single submitter ⚠
- p.Gln87Arg Single submitter ⚠
- p.Glu297Lys Single submitter ⚠
- p.Glu42Asp Single submitter ⚠
- p.Gly368Arg Single submitter ⚠
- p.Gly53Glu Single submitter ⚠
- p.Ile106Met Single submitter ⚠
- p.Ile269Leu Single submitter ⚠
- p.Ile324Asn Single submitter ⚠
- p.Ile441Val Single submitter ⚠
- p.Leu171Pro Single submitter ⚠
- p.Leu206Phe Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu291Trp Single submitter ⚠
- p.Leu421Gln Single submitter ⚠
- p.Leu442Val Single submitter ⚠
- p.Leu457Pro Single submitter ⚠
- p.Leu559Arg Single submitter ⚠
- p.Lys15Glu Single submitter ⚠
- p.Lys214Arg Single submitter ⚠
- p.Lys214Asn Single submitter ⚠
- p.Lys328Thr Single submitter ⚠
- p.Lys406Glu Single submitter ⚠
- p.Met315Val Single submitter ⚠
- p.Met322Thr Single submitter ⚠
- p.Phe104Cys Single submitter ⚠
- p.Phe156Ile Single submitter ⚠
- p.Phe172Leu Single submitter ⚠
- p.Phe459Ile Single submitter ⚠
- p.Phe459Leu Single submitter ⚠
- p.Pro250Thr Single submitter ⚠
- p.Pro258Leu Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Pro90Arg Single submitter ⚠
- p.Ser288Ala Single submitter ⚠
- p.Ser313Leu Single submitter ⚠
- p.Ser316Asn Single submitter ⚠
- p.Ser401Pro Single submitter ⚠
- p.Ser401Tyr Single submitter ⚠
- p.Ser499Gly Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Thr193Ile Single submitter ⚠
- p.Thr361Ala Single submitter ⚠
- p.Thr568Arg Single submitter ⚠
- p.Thr78Ala Single submitter ⚠
- p.Trp286Cys Single submitter ⚠
- p.Tyr338His Single submitter ⚠
- p.Tyr423Cys Single submitter ⚠
- p.Tyr491Cys Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val165Phe Single submitter ⚠
- p.Val168Ala Single submitter ⚠
- p.Val168Leu Single submitter
- p.Val170Met Single submitter ⚠
- p.Val321Ile Single submitter ⚠
- p.Val346Ile Single submitter ⚠
- p.Val462Ile Single submitter ⚠
- p.Val462Leu Single submitter ⚠
- p.Val492Ile Single submitter ⚠