NOX5 — 122 ClinVar variants
All ClinVar germline NOX5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 105 flagged for review →
4 Benign · 8 Likely benign · 110 Uncertain significance
Full NOX5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 105
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 85
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOX5 p.Ala285Val Uncertain significance Single submitter
- NOX5 p.Ala344Pro Uncertain significance Single submitter
- NOX5 p.Ala373Thr Uncertain significance Single submitter
- NOX5 p.Ala661Ser Uncertain significance Single submitter
- NOX5 p.Ala664Ser Uncertain significance Single submitter
- NOX5 p.Ala729Thr Uncertain significance Single submitter
- NOX5 p.Ala8Gly Uncertain significance Single submitter
- NOX5 p.Ala8Thr Uncertain significance Single submitter
- NOX5 p.Arg191Leu Uncertain significance Single submitter
- NOX5 p.Arg220Cys Uncertain significance Single submitter
- NOX5 p.Arg223Leu Uncertain significance Single submitter
- NOX5 p.Arg223Trp Uncertain significance Single submitter
- NOX5 p.Arg297Gln Uncertain significance Single submitter
- NOX5 p.Arg390Cys Uncertain significance Single submitter
- NOX5 p.Arg465Trp Uncertain significance Single submitter
- NOX5 p.Arg542Ser Uncertain significance Single submitter
- NOX5 p.Arg644Gln Uncertain significance Single submitter
- NOX5 p.Arg64Leu Uncertain significance Single submitter
- NOX5 p.Arg668His Uncertain significance Single submitter
- NOX5 p.Arg712Cys Uncertain significance Single submitter
- NOX5 p.Arg712His Uncertain significance Single submitter
- NOX5 p.Arg717Gln Uncertain significance Single submitter
- NOX5 p.Asn480His Uncertain significance Single submitter
- NOX5 p.Asn640Lys Uncertain significance Single submitter
- NOX5 p.Asn699Ser Uncertain significance Single submitter
- NOX5 p.Asp192Asn Uncertain significance Single submitter
- NOX5 p.Asp262Asn Uncertain significance Single submitter
- NOX5 p.Asp262Glu Uncertain significance Single submitter
- NOX5 p.Asp72Asn Uncertain significance Single submitter
- NOX5 p.Cys241Trp Uncertain significance Single submitter
- NOX5 p.Gln33Arg Uncertain significance Single submitter
- NOX5 p.Glu13Asp Uncertain significance Single submitter
- NOX5 p.Glu175Lys Uncertain significance Single submitter
- NOX5 p.Glu22Lys Uncertain significance Single submitter
- NOX5 p.Glu623Lys Uncertain significance Single submitter
- NOX5 p.Glu647Lys Uncertain significance Single submitter
- NOX5 p.Glu662Lys Uncertain significance Single submitter
- NOX5 p.Glu754Gly Uncertain significance Single submitter
- NOX5 p.Gly11Cys Uncertain significance Single submitter
- NOX5 p.Gly11Val Uncertain significance Single submitter
- NOX5 p.Gly272Arg Uncertain significance Single submitter
- NOX5 p.Gly365Ser Uncertain significance Single submitter
- NOX5 p.Gly529Asp Uncertain significance Single submitter
- NOX5 p.Gly592Ser Uncertain significance Single submitter
- NOX5 p.Gly681Arg Uncertain significance Single submitter
- NOX5 p.Gly708Arg Uncertain significance Single submitter
- NOX5 p.Ile185Val Uncertain significance Single submitter
- NOX5 p.Ile567Val Uncertain significance Single submitter
- NOX5 p.Leu146Pro Uncertain significance Single submitter
- NOX5 p.Leu190Pro Uncertain significance Single submitter
- NOX5 p.Leu239Met Uncertain significance Single submitter
- NOX5 p.Leu47Val Uncertain significance Single submitter
- NOX5 p.Leu631Pro Uncertain significance Single submitter
- NOX5 p.Leu86Gln Uncertain significance Single submitter
- NOX5 p.Leu98Phe Uncertain significance Single submitter
- NOX5 p.Lys99Asn Uncertain significance Single submitter
- NOX5 p.Met381Val Uncertain significance Single submitter
- NOX5 p.Met541Ile Uncertain significance Single submitter
- NOX5 p.Met541Thr Uncertain significance Single submitter
- NOX5 p.Phe395Val Uncertain significance Single submitter
- NOX5 p.Phe469Ser Uncertain significance Single submitter
- NOX5 p.Phe596Ile Uncertain significance Single submitter
- NOX5 p.Phe66Leu Uncertain significance Single submitter
- NOX5 p.Phe738Ser Uncertain significance Single submitter
- NOX5 p.Pro127Leu Uncertain significance Single submitter
- NOX5 p.Pro217Thr Uncertain significance Single submitter
- NOX5 p.Pro221Arg Uncertain significance Single submitter
- NOX5 p.Pro369Leu Uncertain significance Single submitter
- NOX5 p.Pro94Leu Uncertain significance Single submitter
- NOX5 p.Ser152Leu Uncertain significance Single submitter
- NOX5 p.Ser176Leu Uncertain significance Single submitter
- NOX5 p.Ser366Leu Uncertain significance Single submitter
- NOX5 p.Ser496Asn Uncertain significance Single submitter
- NOX5 p.Ser521Phe Uncertain significance Single submitter
- NOX5 p.Ser598Thr Uncertain significance Single submitter
- NOX5 p.Ser74Asn Uncertain significance Single submitter
- NOX5 p.Thr148Ala Uncertain significance Single submitter
- NOX5 p.Thr515Ala Uncertain significance Single submitter
- NOX5 p.Thr707Met Uncertain significance Single submitter
- NOX5 p.Trp27Ser Uncertain significance Single submitter
- NOX5 p.Trp362Leu Uncertain significance Single submitter
- NOX5 p.Val109Ala Uncertain significance Single submitter
- NOX5 p.Val320Met Uncertain significance Single submitter
- NOX5 p.Val330Glu Uncertain significance Single submitter
- NOX5 p.Val585Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- NOX5 p.Ala172Glu Uncertain significance Single submitter
- NOX5 p.Arg147Ser Uncertain significance Single submitter
- NOX5 p.Arg191Gly Uncertain significance Single submitter
- NOX5 p.Arg261Pro Uncertain significance Single submitter
- NOX5 p.Arg291Cys Uncertain significance Single submitter
- NOX5 p.Arg668Cys Uncertain significance Single submitter
- NOX5 p.Asp178Asn Uncertain significance Single submitter
- NOX5 p.Asp42Tyr Uncertain significance Single submitter
- NOX5 p.Asp684Asn Uncertain significance Single submitter
- NOX5 p.Gln275Arg Uncertain significance Single submitter
- NOX5 p.Gln660Lys Uncertain significance Single submitter
- NOX5 p.Leu161Arg Uncertain significance Single submitter
- NOX5 p.Leu289Phe Uncertain significance Single submitter
- NOX5 p.Pro466Ser Uncertain significance Single submitter
- NOX5 p.Pro466Thr Uncertain significance Single submitter
- NOX5 p.Thr711Met Uncertain significance Single submitter
- NOX5 p.Trp295Cys Uncertain significance Single submitter
- NOX5 p.Tyr471Cys Uncertain significance Single submitter
- NOX5 p.Tyr487Cys Uncertain significance Single submitter
- NOX5 p.Tyr675His Uncertain significance Single submitter
All NOX5 variants
Benign 4
- c.1899+7A>G Multiple submitters
- p.Arg759Gly Multiple submitters
- p.Trp300Ter Multiple submitters
- p.Lys97Ile Single submitter
Likely benign 8
- p.Arg29Gln Single submitter
- p.Asn699Lys Single submitter
- p.Glu44Lys Single submitter
- p.Gly550Val Single submitter
- p.Gly757Ser Single submitter
- p.Leu378= Single submitter
- p.Ser366= Single submitter
- p.Ser547Leu Single submitter
Uncertain significance 110
- p.Ala172Glu Single submitter ⚠
- p.Ala256Val Single submitter
- p.Ala285Val Single submitter ⚠
- p.Ala344Pro Single submitter ⚠
- p.Ala373Thr Single submitter ⚠
- p.Ala661Ser Single submitter ⚠
- p.Ala664Ser Single submitter ⚠
- p.Ala729Thr Single submitter ⚠
- p.Ala8Gly Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg147Ser Single submitter ⚠
- p.Arg191Gly Single submitter ⚠
- p.Arg191Leu Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg223Leu Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg261Pro Single submitter ⚠
- p.Arg291Cys Single submitter ⚠
- p.Arg297Gln Single submitter ⚠
- p.Arg390Cys Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg542Ser Single submitter ⚠
- p.Arg644Gln Single submitter ⚠
- p.Arg64Leu Single submitter ⚠
- p.Arg668Cys Single submitter ⚠
- p.Arg668His Single submitter ⚠
- p.Arg712Cys Single submitter ⚠
- p.Arg712His Single submitter ⚠
- p.Arg717Gln Single submitter ⚠
- p.Asn480His Single submitter ⚠
- p.Asn640Lys Single submitter ⚠
- p.Asn699Ser Single submitter ⚠
- p.Asp178Asn Single submitter ⚠
- p.Asp192Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp262Glu Single submitter ⚠
- p.Asp42Tyr Single submitter ⚠
- p.Asp684Asn Single submitter ⚠
- p.Asp72Asn Single submitter ⚠
- p.Cys241Trp Single submitter ⚠
- p.Gln275Arg Single submitter ⚠
- p.Gln33Arg Single submitter ⚠
- p.Gln660Lys Single submitter ⚠
- p.Glu13Asp Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Glu488Gln Single submitter
- p.Glu623Lys Single submitter ⚠
- p.Glu647Lys Single submitter ⚠
- p.Glu662Lys Single submitter ⚠
- p.Glu754Gly Single submitter ⚠
- p.Gly11Cys Single submitter ⚠
- p.Gly11Val Single submitter ⚠
- p.Gly272Arg Single submitter ⚠
- p.Gly365Ser Single submitter ⚠
- p.Gly529Asp Single submitter ⚠
- p.Gly592Ser Single submitter ⚠
- p.Gly681Arg Single submitter ⚠
- p.Gly708Arg Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile567Val Single submitter ⚠
- p.Leu146Pro Single submitter ⚠
- p.Leu161Arg Single submitter ⚠
- p.Leu190Pro Single submitter ⚠
- p.Leu239Met Single submitter ⚠
- p.Leu289Phe Single submitter ⚠
- p.Leu47Val Single submitter ⚠
- p.Leu631Pro Single submitter ⚠
- p.Leu82Val Single submitter
- p.Leu86Gln Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys99Asn Single submitter ⚠
- p.Met381Val Single submitter ⚠
- p.Met541Ile Single submitter ⚠
- p.Met541Thr Single submitter ⚠
- p.Phe283Leu Single submitter
- p.Phe395Val Single submitter ⚠
- p.Phe469Ser Single submitter ⚠
- p.Phe596Ile Single submitter ⚠
- p.Phe66Leu Single submitter ⚠
- p.Phe738Ser Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro217Thr Single submitter ⚠
- p.Pro221Arg Single submitter ⚠
- p.Pro369Leu Single submitter ⚠
- p.Pro466Ser Single submitter ⚠
- p.Pro466Thr Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser152Leu Single submitter ⚠
- p.Ser176Leu Single submitter ⚠
- p.Ser366Leu Single submitter ⚠
- p.Ser496Asn Single submitter ⚠
- p.Ser521Phe Single submitter ⚠
- p.Ser598Thr Single submitter ⚠
- p.Ser74Asn Single submitter ⚠
- p.Thr148Ala Single submitter ⚠
- p.Thr515Ala Single submitter ⚠
- p.Thr707Met Single submitter ⚠
- p.Thr711Met Single submitter ⚠
- p.Trp27Ser Single submitter ⚠
- p.Trp295Cys Single submitter ⚠
- p.Trp362Leu Single submitter ⚠
- p.Tyr471Cys Single submitter ⚠
- p.Tyr487Cys Single submitter ⚠
- p.Tyr675His Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val320Met Single submitter ⚠
- p.Val330Glu Single submitter ⚠
- p.Val585Leu Single submitter
- p.Val585Met Single submitter ⚠