NPY1R — 35 ClinVar variants
All ClinVar germline NPY1R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 33 Uncertain significance
Full NPY1R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NPY1R p.Ala191Val Uncertain significance Single submitter
- NPY1R p.Arg146Gln Uncertain significance Single submitter
- NPY1R p.Arg153Lys Uncertain significance Single submitter
- NPY1R p.Arg237Cys Uncertain significance Single submitter
- NPY1R p.Asn297Ser Uncertain significance Single submitter
- NPY1R p.Gln8His Uncertain significance Single submitter
- NPY1R p.Gly321Glu Uncertain significance Single submitter
- NPY1R p.Ile263Met Uncertain significance Single submitter
- NPY1R p.Ile52Phe Uncertain significance Single submitter
- NPY1R p.Ile63Leu Uncertain significance Single submitter
- NPY1R p.Leu133His Uncertain significance Single submitter
- NPY1R p.Leu216Val Uncertain significance Single submitter
- NPY1R p.Leu43Ser Uncertain significance Single submitter
- NPY1R p.Lys195Arg Uncertain significance Single submitter
- NPY1R p.Lys252Arg Uncertain significance Single submitter
- NPY1R p.Lys373Thr Uncertain significance Single submitter
- NPY1R p.Met112Thr Uncertain significance Single submitter
- NPY1R p.Met245Val Uncertain significance Single submitter
- NPY1R p.Met264Leu Uncertain significance Single submitter
- NPY1R p.Met39Ile Uncertain significance Single submitter
- NPY1R p.Phe334Leu Uncertain significance Single submitter
- NPY1R p.Ser206Phe Uncertain significance Single submitter
- NPY1R p.Ser312Pro Uncertain significance Single submitter
- NPY1R p.Val285Met Uncertain significance Single submitter
- NPY1R p.Val315Ile Uncertain significance Single submitter
- NPY1R p.Val55Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NPY1R variants
Benign 1
- p.Lys374Thr Multiple submitters
Likely benign 1
- p.Asn251Ser Single submitter
Uncertain significance 33
- p.Ala191Val Single submitter ⚠
- p.Ala271Val Single submitter
- p.Arg146Gln Single submitter ⚠
- p.Arg153Lys Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Asn186Lys Single submitter ⚠
- p.Asn297Ser Single submitter ⚠
- p.Gln8His Single submitter ⚠
- p.Gly321Glu Single submitter ⚠
- p.Ile263Met Single submitter ⚠
- p.Ile52Phe Single submitter ⚠
- p.Ile63Leu Single submitter ⚠
- p.Ile79Thr Single submitter ⚠
- p.Leu133His Single submitter ⚠
- p.Leu216Val Single submitter ⚠
- p.Leu301Ser Single submitter
- p.Leu43Ser Single submitter ⚠
- p.Lys195Arg Single submitter ⚠
- p.Lys252Arg Single submitter ⚠
- p.Lys373Thr Single submitter ⚠
- p.Met103Ile Single submitter ⚠
- p.Met112Thr Single submitter ⚠
- p.Met245Val Single submitter ⚠
- p.Met264Leu Single submitter ⚠
- p.Met39Ile Single submitter ⚠
- p.Phe334Leu Single submitter ⚠
- p.Ser206Phe Single submitter ⚠
- p.Ser312Pro Single submitter ⚠
- p.Thr313Ile Single submitter ⚠
- p.Tyr220His Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val315Ile Single submitter ⚠
- p.Val55Ile Single submitter ⚠