NPY2R — 49 ClinVar variants
All ClinVar germline NPY2R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
4 Benign · 5 Likely benign · 40 Uncertain significance
Full NPY2R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NPY2R p.Ala90Val Uncertain significance Single submitter
- NPY2R p.Arg148Gln Uncertain significance Single submitter
- NPY2R p.Asp9Ala Uncertain significance Single submitter
- NPY2R p.Glu115Lys Uncertain significance Single submitter
- NPY2R p.Glu211Asp Uncertain significance Single submitter
- NPY2R p.Glu211Gly Uncertain significance Single submitter
- NPY2R p.Glu39Gln Uncertain significance Single submitter
- NPY2R p.Gly30Ser Uncertain significance Single submitter
- NPY2R p.Ile200Phe Uncertain significance Single submitter
- NPY2R p.Ile349Met Uncertain significance Single submitter
- NPY2R p.Ile66Thr Uncertain significance Single submitter
- NPY2R p.Leu179Met Uncertain significance Single submitter
- NPY2R p.Lys304Arg Uncertain significance Single submitter
- NPY2R p.Lys360Glu Uncertain significance Single submitter
- NPY2R p.Lys45Arg Uncertain significance Single submitter
- NPY2R p.Met17Arg Uncertain significance Single submitter
- NPY2R p.Phe78Tyr Uncertain significance Single submitter
- NPY2R p.Pro120Ser Uncertain significance Single submitter
- NPY2R p.Pro24Gln Uncertain significance Single submitter
- NPY2R p.Pro371Thr Uncertain significance Single submitter
- NPY2R p.Pro38Leu Uncertain significance Single submitter
- NPY2R p.Ser137Phe Uncertain significance Single submitter
- NPY2R p.Ser213Arg Uncertain significance Single submitter
- NPY2R p.Ser317Phe Uncertain significance Single submitter
- NPY2R p.Ser351Pro Uncertain significance Single submitter
- NPY2R p.Ser369Arg Uncertain significance Single submitter
- NPY2R p.Thr13Arg Uncertain significance Single submitter
- NPY2R p.Thr26Lys Uncertain significance Single submitter
- NPY2R p.Thr379Ala Uncertain significance Single submitter
- NPY2R p.Tyr154Cys Uncertain significance Single submitter
- NPY2R p.Tyr259His Uncertain significance Single submitter
- NPY2R p.Val271Leu Uncertain significance Single submitter
- NPY2R p.Val291Ile Uncertain significance Single submitter
- NPY2R p.Val309Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NPY2R variants
Benign 4
- p.Ala172Thr Multiple submitters
- p.Leu53= Multiple submitters
- p.Val218= Multiple submitters
- p.Gly326= Single submitter
Likely benign 5
- p.Arg345Gln Multiple submitters
- p.Gly370= Single submitter
- p.Leu122= Single submitter
- p.Pro196= Single submitter
- p.Tyr22His Single submitter
Uncertain significance 40
- p.Ala184Thr Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg82Cys Single submitter
- p.Asp9Ala Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu211Asp Single submitter ⚠
- p.Glu211Gly Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.Gly30Ser Single submitter ⚠
- p.Ile200Phe Single submitter ⚠
- p.Ile349Met Single submitter ⚠
- p.Ile66Thr Single submitter ⚠
- p.Leu179Met Single submitter ⚠
- p.Lys304Arg Single submitter ⚠
- p.Lys360Glu Single submitter ⚠
- p.Lys45Arg Single submitter ⚠
- p.Met17Arg Single submitter ⚠
- p.Phe78Tyr Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Pro24Gln Single submitter ⚠
- p.Pro371Thr Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Ser137Phe Single submitter ⚠
- p.Ser165Asn Single submitter ⚠
- p.Ser213Arg Single submitter ⚠
- p.Ser317Phe Single submitter ⚠
- p.Ser351Pro Single submitter ⚠
- p.Ser369Arg Single submitter ⚠
- p.Thr13Arg Single submitter ⚠
- p.Thr26Lys Single submitter ⚠
- p.Thr379Ala Single submitter ⚠
- p.Tyr110His Single submitter ⚠
- p.Tyr154Cys Single submitter ⚠
- p.Tyr259His Single submitter ⚠
- p.Val271Leu Single submitter ⚠
- p.Val291Ile Single submitter ⚠
- p.Val309Ala Single submitter ⚠