NPY4R — 45 ClinVar variants
All ClinVar germline NPY4R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
9 Benign · 36 Uncertain significance
Full NPY4R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NPY4R p.Arg139Ser Uncertain significance Single submitter
- NPY4R p.Asn29Lys Uncertain significance Single submitter
- NPY4R p.Asp39Gly Uncertain significance Single submitter
- NPY4R p.Cys122Phe Uncertain significance Single submitter
- NPY4R p.Cys122Tyr Uncertain significance Single submitter
- NPY4R p.Cys307Gly Uncertain significance Single submitter
- NPY4R p.Gln342Lys Uncertain significance Single submitter
- NPY4R p.Gly228Asp Uncertain significance Single submitter
- NPY4R p.His291Asp Uncertain significance Single submitter
- NPY4R p.His299Tyr Uncertain significance Single submitter
- NPY4R p.Ile129Val Uncertain significance Single submitter
- NPY4R p.Ile213Val Uncertain significance Single submitter
- NPY4R p.Ile297Thr Uncertain significance Single submitter
- NPY4R p.Leu134Pro Uncertain significance Single submitter
- NPY4R p.Leu142Pro Uncertain significance Single submitter
- NPY4R p.Leu60Arg Uncertain significance Single submitter
- NPY4R p.Leu93Phe Uncertain significance Single submitter
- NPY4R p.Met312Ile Uncertain significance Single submitter
- NPY4R p.Phe221Cys Uncertain significance Single submitter
- NPY4R p.Ser131Leu Uncertain significance Single submitter
- NPY4R p.Thr112Asn Uncertain significance Single submitter
- NPY4R p.Thr216Ile Uncertain significance Single submitter
- NPY4R p.Tyr157Cys Uncertain significance Single submitter
- NPY4R p.Val199Leu Uncertain significance Single submitter
- NPY4R p.Val337Leu Uncertain significance Single submitter
- NPY4R p.Val38Glu Uncertain significance Single submitter
- NPY4R p.Val65Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All NPY4R variants
Benign 9
- p.Ala99Ser Single submitter
- p.Cys240= Single submitter
- p.Cys240Arg Single submitter
- p.Cys316= Single submitter
- p.His299= Single submitter
- p.Ile44= Single submitter
- p.Leu231= Single submitter
- p.Leu78= Single submitter
- p.Ser349= Single submitter
Uncertain significance 36
- p.Ala275Val Single submitter
- p.Arg139Ser Single submitter ⚠
- p.Asn29Lys Single submitter ⚠
- p.Asn328Tyr Single submitter
- p.Asp39Gly Single submitter ⚠
- p.Cys122Phe Single submitter ⚠
- p.Cys122Tyr Single submitter ⚠
- p.Cys307Gly Single submitter ⚠
- p.Cys316Ser Single submitter
- p.Gln342Lys Single submitter ⚠
- p.Gly228Asp Single submitter ⚠
- p.His291Asp Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Ile213Val Single submitter ⚠
- p.Ile297Thr Single submitter ⚠
- p.Leu134Pro Single submitter ⚠
- p.Leu142Pro Single submitter ⚠
- p.Leu195Arg Single submitter ⚠
- p.Leu60Arg Single submitter ⚠
- p.Leu93Phe Single submitter ⚠
- p.Lys363Asn Single submitter
- p.Met270Leu Single submitter
- p.Met312Ile Single submitter ⚠
- p.Met90Thr Single submitter ⚠
- p.Phe221Cys Single submitter ⚠
- p.Phe320Leu Single submitter ⚠
- p.Ser131Leu Single submitter ⚠
- p.Thr112Asn Single submitter ⚠
- p.Thr216Ile Single submitter ⚠
- p.Trp149Arg Single submitter ⚠
- p.Tyr157Cys Single submitter ⚠
- p.Val199Leu Single submitter ⚠
- p.Val337Leu Single submitter ⚠
- p.Val38Glu Single submitter ⚠
- p.Val65Met Single submitter ⚠