NPY5R — 61 ClinVar variants
All ClinVar germline NPY5R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
6 Likely benign · 55 Uncertain significance
Full NPY5R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NPY5R p.Ala14Pro Uncertain significance Single submitter
- NPY5R p.Ala190Thr Uncertain significance Single submitter
- NPY5R p.Ala20Ser Uncertain significance Single submitter
- NPY5R p.Ala434Gly Uncertain significance Single submitter
- NPY5R p.Arg23Trp Uncertain significance Single submitter
- NPY5R p.Arg287Lys Uncertain significance Single submitter
- NPY5R p.Arg288Lys Uncertain significance Single submitter
- NPY5R p.Arg354His Uncertain significance Single submitter
- NPY5R p.Arg70Gly Uncertain significance Single submitter
- NPY5R p.Arg70His Uncertain significance Single submitter
- NPY5R p.Asn10Asp Uncertain significance Single submitter
- NPY5R p.Asn149Asp Uncertain significance Single submitter
- NPY5R p.Asn429Tyr Uncertain significance Single submitter
- NPY5R p.Asp435Tyr Uncertain significance Single submitter
- NPY5R p.Cys442Ser Uncertain significance Single submitter
- NPY5R p.Gln106Lys Uncertain significance Single submitter
- NPY5R p.Gln219His Uncertain significance Single submitter
- NPY5R p.Glu16Asp Uncertain significance Single submitter
- NPY5R p.Glu250Ala Uncertain significance Single submitter
- NPY5R p.Glu301Gly Uncertain significance Single submitter
- NPY5R p.Glu338Asp Uncertain significance Single submitter
- NPY5R p.Gly266Glu Uncertain significance Single submitter
- NPY5R p.Gly317Val Uncertain significance Single submitter
- NPY5R p.Gly332Ala Uncertain significance Single submitter
- NPY5R p.His115Arg Uncertain significance Single submitter
- NPY5R p.His275Arg Uncertain significance Single submitter
- NPY5R p.Ile147Thr Uncertain significance Single submitter
- NPY5R p.Ile160Met Uncertain significance Single submitter
- NPY5R p.Ile330Thr Uncertain significance Single submitter
- NPY5R p.Leu151Val Uncertain significance Single submitter
- NPY5R p.Leu249Arg Uncertain significance Single submitter
- NPY5R p.Leu323Phe Uncertain significance Single submitter
- NPY5R p.Leu397Pro Uncertain significance Single submitter
- NPY5R p.Leu66Phe Uncertain significance Single submitter
- NPY5R p.Leu66Val Uncertain significance Single submitter
- NPY5R p.Lys11Glu Uncertain significance Single submitter
- NPY5R p.Lys283Gln Uncertain significance Single submitter
- NPY5R p.Lys34Thr Uncertain significance Single submitter
- NPY5R p.Phe329Ile Uncertain significance Single submitter
- NPY5R p.Pro28Ala Uncertain significance Single submitter
- NPY5R p.Pro300Ala Uncertain significance Single submitter
- NPY5R p.Pro313Ala Uncertain significance Single submitter
- NPY5R p.Ser262Tyr Uncertain significance Single submitter
- NPY5R p.Ser278Thr Uncertain significance Single submitter
- NPY5R p.Thr152Arg Uncertain significance Single submitter
- NPY5R p.Thr152Ser Uncertain significance Single submitter
- NPY5R p.Thr19Ile Uncertain significance Single submitter
- NPY5R p.Thr293Ile Uncertain significance Single submitter
- NPY5R p.Tyr368Cys Uncertain significance Single submitter
- NPY5R p.Tyr425Cys Uncertain significance Single submitter
- NPY5R p.Val199Ile Uncertain significance Single submitter
- NPY5R p.Val229Ile Uncertain significance Single submitter
- NPY5R p.Val437Glu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All NPY5R variants
Likely benign 6
- p.Glu306Lys Single submitter
- p.Gly273Ser Single submitter
- p.Gly55= Single submitter
- p.Val138= Single submitter
- p.Val437Met Single submitter
- p.Leu405= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 55
- p.Ala14Pro Single submitter ⚠
- p.Ala190Thr Single submitter ⚠
- p.Ala20Ser Single submitter ⚠
- p.Ala434Gly Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg287Lys Single submitter ⚠
- p.Arg288Lys Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Asn10Asp Single submitter ⚠
- p.Asn149Asp Single submitter ⚠
- p.Asn429Tyr Single submitter ⚠
- p.Asp435Tyr Single submitter ⚠
- p.Cys122Gly Single submitter
- p.Cys336Arg Single submitter ⚠
- p.Cys442Ser Single submitter ⚠
- p.Gln106Lys Single submitter ⚠
- p.Gln219His Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Glu250Ala Single submitter ⚠
- p.Glu301Gly Single submitter ⚠
- p.Glu338Asp Single submitter ⚠
- p.Gly266Glu Single submitter ⚠
- p.Gly317Val Single submitter ⚠
- p.Gly332Ala Single submitter ⚠
- p.His115Arg Single submitter ⚠
- p.His275Arg Single submitter ⚠
- p.Ile147Thr Single submitter ⚠
- p.Ile160Met Single submitter ⚠
- p.Ile330Thr Single submitter ⚠
- p.Leu151Val Single submitter ⚠
- p.Leu249Arg Single submitter ⚠
- p.Leu323Phe Single submitter ⚠
- p.Leu397Pro Single submitter ⚠
- p.Leu66Phe Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Lys11Glu Single submitter ⚠
- p.Lys283Gln Single submitter ⚠
- p.Lys34Thr Single submitter ⚠
- p.Phe329Ile Single submitter ⚠
- p.Pro28Ala Single submitter ⚠
- p.Pro300Ala Single submitter ⚠
- p.Pro313Ala Single submitter ⚠
- p.Ser262Tyr Single submitter ⚠
- p.Ser278Thr Single submitter ⚠
- p.Thr152Arg Single submitter ⚠
- p.Thr152Ser Single submitter ⚠
- p.Thr19Ile Single submitter ⚠
- p.Thr293Ile Single submitter ⚠
- p.Tyr368Cys Single submitter ⚠
- p.Tyr425Cys Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val229Ile Single submitter ⚠
- p.Val437Glu Single submitter ⚠