NQO2 — 35 ClinVar variants
All ClinVar germline NQO2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Benign · 1 Likely benign · 32 Uncertain significance
Full NQO2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NQO2 p.Ala11Val Uncertain significance Single submitter
- NQO2 p.Arg93Trp Uncertain significance Single submitter
- NQO2 p.Glu200Gly Uncertain significance Single submitter
- NQO2 p.Glu74Lys Uncertain significance Single submitter
- NQO2 p.Gly230Arg Uncertain significance Single submitter
- NQO2 p.His226Gln Uncertain significance Single submitter
- NQO2 p.His228Arg Uncertain significance Single submitter
- NQO2 p.Leu113Pro Uncertain significance Single submitter
- NQO2 p.Leu7Pro Uncertain significance Single submitter
- NQO2 p.Lys90Arg Uncertain significance Single submitter
- NQO2 p.Phe127Cys Uncertain significance Single submitter
- NQO2 p.Val147Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- NQO2 p.Asn162Asp Uncertain significance Single submitter
- NQO2 p.Asn162Lys Uncertain significance Single submitter
- NQO2 p.Asn19Ile Uncertain significance Single submitter
- NQO2 p.Asn62Asp Uncertain significance Single submitter
- NQO2 p.Asp134Asn Uncertain significance Single submitter
- NQO2 p.Asp84Tyr Uncertain significance Single submitter
- NQO2 p.Glu154Lys Uncertain significance Single submitter
- NQO2 p.Glu71Gly Uncertain significance Single submitter
- NQO2 p.Glu74Asp Uncertain significance Single submitter
- NQO2 p.Gly136Ser Uncertain significance Single submitter
- NQO2 p.Gly140Asp Uncertain significance Single submitter
- NQO2 p.Gly20Arg Uncertain significance Single submitter
- NQO2 p.Ile56Asn Uncertain significance Single submitter
- NQO2 p.Leu7Phe Uncertain significance Single submitter
-
NQO2 p.Lys16Arg
Benign
Single submitter
ovarian cancer
- NQO2 p.Lys77Met Uncertain significance Single submitter
- NQO2 p.Phe168Cys Uncertain significance Single submitter
- NQO2 p.Ser135Phe Uncertain significance Single submitter
- NQO2 p.Ser190Asn Likely benign Single submitter
- NQO2 p.Trp216Gly Uncertain significance Single submitter
- NQO2 p.Tyr10Cys Uncertain significance Single submitter
- NQO2 p.Tyr43Cys Uncertain significance Single submitter
All NQO2 variants
Benign 2
- c.173-5G>A Single submitter
- p.Lys16Arg Single submitter ovarian cancer ⚠
Likely benign 1
- p.Ser190Asn Single submitter ⚠
Uncertain significance 32
- p.Ala11Val Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn162Asp Single submitter ⚠
- p.Asn162Lys Single submitter ⚠
- p.Asn19Ile Single submitter ⚠
- p.Asn62Asp Single submitter ⚠
- p.Asp134Asn Single submitter ⚠
- p.Asp84Tyr Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Glu200Gly Single submitter ⚠
- p.Glu71Gly Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Glu74Lys Single submitter ⚠
- p.Gly136Ser Single submitter ⚠
- p.Gly140Asp Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.His226Gln Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.Ile56Asn Single submitter ⚠
- p.Leu113Pro Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys77Met Single submitter ⚠
- p.Lys90Arg Single submitter ⚠
- p.Phe127Cys Single submitter ⚠
- p.Phe168Cys Single submitter ⚠
- p.Ser135Phe Single submitter ⚠
- p.Trp216Gly Single submitter ⚠
- p.Tyr10Cys Single submitter ⚠
- p.Tyr43Cys Single submitter ⚠
- p.Val147Ile Single submitter ⚠