NR4A3 — 45 ClinVar variants
All ClinVar germline NR4A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Likely benign · 42 Uncertain significance
Full NR4A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NR4A3 p.Ala19Thr Uncertain significance Single submitter
- NR4A3 p.Ala237Glu Uncertain significance Single submitter
- NR4A3 p.Ala575Gly Uncertain significance Single submitter
- NR4A3 p.Arg187Cys Uncertain significance Single submitter
- NR4A3 p.Arg187Pro Uncertain significance Single submitter
- NR4A3 p.Arg591Lys Uncertain significance Single submitter
- NR4A3 p.Asp157Glu Uncertain significance Single submitter
- NR4A3 p.Asp423Asn Uncertain significance Single submitter
- NR4A3 p.Gly244Val Uncertain significance Single submitter
- NR4A3 p.Gly260Ser Uncertain significance Single submitter
- NR4A3 p.Gly43Cys Uncertain significance Single submitter
- NR4A3 p.Leu254Val Uncertain significance Single submitter
- NR4A3 p.Lys454Arg Uncertain significance Single submitter
- NR4A3 p.Pro149Ser Uncertain significance Single submitter
- NR4A3 p.Pro150Gln Uncertain significance Single submitter
- NR4A3 p.Pro161Leu Uncertain significance Single submitter
- NR4A3 p.Pro205Arg Uncertain significance Single submitter
- NR4A3 p.Pro224Gln Uncertain significance Single submitter
- NR4A3 p.Pro253Leu Uncertain significance Single submitter
- NR4A3 p.Ser11Phe Uncertain significance Single submitter
- NR4A3 p.Ser222Asn Uncertain significance Single submitter
- NR4A3 p.Ser23Ile Uncertain significance Single submitter
- NR4A3 p.Ser286Leu Uncertain significance Single submitter
-
NR4A3 p.Ser571Asn
Uncertain significance
Single submitter
extraskeletal myxoid chondrosarcoma
- NR4A3 p.Thr144Ser Uncertain significance Single submitter
- NR4A3 p.Thr21Pro Uncertain significance Single submitter
- NR4A3 p.Thr48Met Uncertain significance Single submitter
- NR4A3 p.Thr50Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- NR4A3 p.Ala473Gly Uncertain significance Single submitter
- NR4A3 p.Gln505His Uncertain significance Single submitter
- NR4A3 p.Glu490Ala Uncertain significance Single submitter
- NR4A3 p.Lys561Thr Uncertain significance Single submitter
- NR4A3 p.Met133Thr Uncertain significance Single submitter
- NR4A3 p.Pro12Leu Uncertain significance Single submitter
- NR4A3 p.Ser516Tyr Uncertain significance Single submitter
All NR4A3 variants
Likely benign 3
- c.1455-8C>A Single submitter
- p.Gly585Arg Single submitter
- p.His112Gln Single submitter
Uncertain significance 42
- p.Ala19Thr Single submitter ⚠
- p.Ala237Glu Single submitter ⚠
- p.Ala473Gly Single submitter ⚠
- p.Ala575Gly Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg187Pro Single submitter ⚠
- p.Arg508His Single submitter
- p.Arg591Lys Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Asp423Asn Single submitter ⚠
- p.Gln505His Single submitter ⚠
- p.Glu490Ala Single submitter ⚠
- p.Gly244Val Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly272Arg Single submitter
- p.Gly43Cys Single submitter ⚠
- p.Leu254Val Single submitter ⚠
- p.Lys454Arg Single submitter ⚠
- p.Lys561Thr Single submitter ⚠
- p.Met133Thr Single submitter ⚠
- p.Phe148Leu Single submitter
- p.Phe193Leu Single submitter
- p.Pro12Leu Single submitter ⚠
- p.Pro140Leu Single submitter
- p.Pro149Ser Single submitter ⚠
- p.Pro150Gln Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro205Arg Single submitter ⚠
- p.Pro224Gln Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Ser11Phe Single submitter ⚠
- p.Ser222Arg Single submitter
- p.Ser222Asn Single submitter ⚠
- p.Ser23Ile Single submitter ⚠
- p.Ser24Trp Single submitter
- p.Ser286Leu Single submitter ⚠
- p.Ser516Tyr Single submitter ⚠
- p.Ser571Asn Single submitter extraskeletal myxoid chondrosarcoma ⚠
- p.Thr144Ser Single submitter ⚠
- p.Thr21Pro Single submitter ⚠
- p.Thr48Met Single submitter ⚠
- p.Thr50Ala Single submitter ⚠