Sugi Variant

Sugi Variant/NRIP1

NRIP1 — 358 ClinVar variants

All ClinVar germline NRIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 237 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 11 Conflicting · 24 Benign · 5 Benign/Likely benign · 70 Likely benign · 245 Uncertain significance

Full NRIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 237

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 191

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 191

Predictors split 36

The independent predictors disagree with each other — read with care.

All NRIP1 variants

Pathogenic 1

Likely pathogenic 2

  • p.Lys931Ter Single submitter congenital anomalies of kidney and urinary tract 3
  • p.Leu1068Pro No assertion criteria congenital anomalies of kidney and urinary tract 3

Conflicting classifications of pathogenicity 11

Benign 24

Benign/Likely benign 5

Likely benign 70

Uncertain significance 245