NSD3 — 140 ClinVar variants
All ClinVar germline NSD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
7 Benign · 10 Likely benign · 123 Uncertain significance
Full NSD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NSD3 p.Ala102Thr Uncertain significance Single submitter
- NSD3 p.Ala1147Gly Uncertain significance Single submitter
- NSD3 p.Ala1291Val Uncertain significance Single submitter
- NSD3 p.Ala1293Val Uncertain significance Single submitter
- NSD3 p.Ala1412Val Uncertain significance Single submitter
- NSD3 p.Ala411Asp Uncertain significance Single submitter
- NSD3 p.Ala674Thr Uncertain significance Single submitter
- NSD3 p.Ala676Val Uncertain significance Single submitter
- NSD3 p.Arg1047Cys Uncertain significance Single submitter
- NSD3 p.Arg1154Gln Uncertain significance Single submitter
- NSD3 p.Arg326Trp Uncertain significance Single submitter
- NSD3 p.Arg383Gln Uncertain significance Single submitter
- NSD3 p.Arg448Gly Uncertain significance Single submitter
- NSD3 p.Arg815Cys Uncertain significance Single submitter
- NSD3 p.Arg815Gly Uncertain significance Single submitter
- NSD3 p.Arg815Leu Uncertain significance Single submitter
-
NSD3 p.Asn1079Lys
Uncertain significance
Single submitter
nut midline carcinoma
- NSD3 p.Asn1106His Uncertain significance Single submitter
- NSD3 p.Asn315Ser Uncertain significance Single submitter
- NSD3 p.Asn849Thr Uncertain significance Single submitter
- NSD3 p.Asn856Ser Uncertain significance Single submitter
- NSD3 p.Asp1240Asn Uncertain significance Single submitter
- NSD3 p.Asp1368Asn Uncertain significance Single submitter
- NSD3 p.Asp1368His Uncertain significance Single submitter
- NSD3 p.Asp1388Ala Uncertain significance Single submitter
- NSD3 p.Gln1049Arg Uncertain significance Single submitter
- NSD3 p.Gln1126Lys Uncertain significance Single submitter
- NSD3 p.Gln141Glu Uncertain significance Single submitter
- NSD3 p.Gln55His Uncertain significance Single submitter
- NSD3 p.Gln58Arg Uncertain significance Single submitter
- NSD3 p.Glu1062Gln Uncertain significance Single submitter
- NSD3 p.Glu461Lys Uncertain significance Single submitter
- NSD3 p.Glu64Asp Uncertain significance Single submitter
- NSD3 p.Gly1285Glu Uncertain significance Single submitter
- NSD3 p.Gly1401Asp Uncertain significance Single submitter
- NSD3 p.Gly56Ala Uncertain significance Single submitter
- NSD3 p.His122Pro Uncertain significance Single submitter
- NSD3 p.His203Arg Uncertain significance Single submitter
- NSD3 p.Ile1422Lys Uncertain significance Single submitter
- NSD3 p.Ile40Thr Uncertain significance Single submitter
- NSD3 p.Ile468Thr Uncertain significance Single submitter
- NSD3 p.Ile544Val Uncertain significance Single submitter
- NSD3 p.Ile545Thr Uncertain significance Single submitter
- NSD3 p.Ile77Val Uncertain significance Single submitter
- NSD3 p.Leu442Phe Uncertain significance Single submitter
- NSD3 p.Lys1215Gln Uncertain significance Single submitter
- NSD3 p.Lys202Arg Uncertain significance Single submitter
- NSD3 p.Lys487Arg Uncertain significance Single submitter
- NSD3 p.Lys699Arg Uncertain significance Single submitter
- NSD3 p.Phe1199Leu Uncertain significance Single submitter
- NSD3 p.Pro130Ala Uncertain significance Single submitter
- NSD3 p.Pro562Ala Uncertain significance Single submitter
- NSD3 p.Pro60Ser Uncertain significance Single submitter
- NSD3 p.Ser1093Pro Uncertain significance Single submitter
- NSD3 p.Ser1290Leu Uncertain significance Single submitter
- NSD3 p.Ser1371Gly Uncertain significance Single submitter
- NSD3 p.Ser183Gly Uncertain significance Single submitter
- NSD3 p.Ser443Leu Uncertain significance Single submitter
- NSD3 p.Ser457Asn Uncertain significance Single submitter
- NSD3 p.Ser536Ile Uncertain significance Single submitter
- NSD3 p.Ser546Cys Uncertain significance Single submitter
- NSD3 p.Ser571Leu Uncertain significance Single submitter
- NSD3 p.Ser644Gly Uncertain significance Single submitter
- NSD3 p.Ser659Asn Uncertain significance Single submitter
- NSD3 p.Ser691Leu Uncertain significance Single submitter
- NSD3 p.Ser78Asn Uncertain significance Single submitter
- NSD3 p.Ser837Asn Uncertain significance Single submitter
- NSD3 p.Ser88Leu Uncertain significance Single submitter
- NSD3 p.Ser928Leu Uncertain significance Single submitter
- NSD3 p.Thr414Ile Uncertain significance Single submitter
- NSD3 p.Thr456Ala Uncertain significance Single submitter
- NSD3 p.Thr533Ala Uncertain significance Single submitter
- NSD3 p.Thr556Ala Uncertain significance Single submitter
- NSD3 p.Thr611Ile Uncertain significance Single submitter
- NSD3 p.Thr614Ser Uncertain significance Single submitter
- NSD3 p.Tyr1009His Uncertain significance Single submitter
- NSD3 p.Tyr1357Cys Uncertain significance Single submitter
- NSD3 p.Tyr647Cys Uncertain significance Single submitter
- NSD3 p.Val1081Ala Uncertain significance Single submitter
- NSD3 p.Val1089Ile Uncertain significance Single submitter
- NSD3 p.Val1395Ala Uncertain significance Single submitter
- NSD3 p.Val1435Leu Uncertain significance Single submitter
- NSD3 p.Val537Phe Uncertain significance Single submitter
- NSD3 p.Val572Ile Uncertain significance Single submitter
- NSD3 p.Val612Met Uncertain significance Single submitter
- NSD3 p.Val640Ala Uncertain significance Single submitter
- NSD3 p.Val840Ile Uncertain significance Single submitter
- NSD3 p.Val867Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- NSD3 p.Ala1090Thr Uncertain significance Single submitter
- NSD3 p.Ala636Thr Uncertain significance Single submitter
- NSD3 p.Arg1402His Uncertain significance Single submitter
- NSD3 p.Arg365Cys Uncertain significance Single submitter
- NSD3 p.Arg584His Uncertain significance Single submitter
- NSD3 p.Arg635His Uncertain significance Single submitter
- NSD3 p.Arg780Cys Uncertain significance Single submitter
- NSD3 p.Arg780His Uncertain significance Single submitter
- NSD3 p.Arg793His Uncertain significance Single submitter
- NSD3 p.Arg815His Uncertain significance Single submitter
- NSD3 p.Asn105Lys Uncertain significance Single submitter
- NSD3 p.Asn1217Ser Uncertain significance Single submitter
- NSD3 p.Glu1298Gly Uncertain significance Single submitter
- NSD3 p.Glu169Ala Uncertain significance Single submitter
- NSD3 p.Glu388Gly Uncertain significance Single submitter
- NSD3 p.Gly10Glu Uncertain significance Single submitter
- NSD3 p.Gly921Glu Uncertain significance Single submitter
- NSD3 p.Lys147Thr Uncertain significance Single submitter
- NSD3 p.Met1335Ile Uncertain significance Single submitter
- NSD3 p.Ser634Arg Uncertain significance Single submitter
- NSD3 p.Thr1271Met Uncertain significance Single submitter
- NSD3 p.Tyr826Cys Uncertain significance Single submitter
All NSD3 variants
Benign 7
- p.Ala1212= Multiple submitters
- p.Arg383Pro Multiple submitters
- p.Asn987= Multiple submitters
- p.Ser754Leu Multiple submitters
- p.Ser855Gly Multiple submitters
- p.Thr186Met Multiple submitters
- c.3760+3A>G Single submitter
Likely benign 10
- p.Thr556Met Multiple submitters
- p.Ala458Val Single submitter
- p.Glu462= No assertion criteria NSD3-related disorder
- p.Leu1266= No assertion criteria NSD3-related disorder
- p.Pro464= No assertion criteria NSD3-related disorder
- p.Ser653= No assertion criteria NSD3-related disorder
- p.Ser754= No assertion criteria NSD3-related disorder
- p.Val1175Ile No assertion criteria NSD3-related disorder
- p.Val438= No assertion criteria NSD3-related disorder
- p.Val79= No assertion criteria NSD3-related disorder
Uncertain significance 123
- c.1855+1G>A Single submitter
- p.Ala102Thr Single submitter ⚠
- p.Ala1090Thr Single submitter ⚠
- p.Ala1147Gly Single submitter ⚠
- p.Ala1291Val Single submitter ⚠
- p.Ala1293Val Single submitter ⚠
- p.Ala1412Val Single submitter ⚠
- p.Ala411Asp Single submitter ⚠
- p.Ala636Thr Single submitter ⚠
- p.Ala674Thr Single submitter ⚠
- p.Ala676Val Single submitter ⚠
- p.Arg1047Cys Single submitter ⚠
- p.Arg1154Gln Single submitter ⚠
- p.Arg1402His Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg383Gly Single submitter
- p.Arg448Gly Single submitter ⚠
- p.Arg448Pro Single submitter
- p.Arg584His Single submitter ⚠
- p.Arg635His Single submitter ⚠
- p.Arg780Cys Single submitter ⚠
- p.Arg780His Single submitter ⚠
- p.Arg793His Single submitter ⚠
- p.Arg815Cys Single submitter ⚠
- p.Arg815Gly Single submitter ⚠
- p.Arg815His Single submitter ⚠
- p.Arg815Leu Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asn1079Lys Single submitter nut midline carcinoma ⚠
- p.Asn1106His Single submitter ⚠
- p.Asn1217Ser Single submitter ⚠
- p.Asn315Ser Single submitter ⚠
- p.Asn849Thr Single submitter ⚠
- p.Asn856Ser Single submitter ⚠
- p.Asp1240Asn Single submitter ⚠
- p.Asp1368Asn Single submitter ⚠
- p.Asp1368His Single submitter ⚠
- p.Asp1388Ala Single submitter ⚠
- p.Asp43His Single submitter
- p.Asp670fs Single submitter
- p.Asp670Gly Single submitter
- p.Asp994Tyr Single submitter
- p.Gln1049Arg Single submitter ⚠
- p.Gln1126Lys Single submitter ⚠
- p.Gln141Glu Single submitter ⚠
- p.Gln55His Single submitter ⚠
- p.Gln58Arg Single submitter ⚠
- p.Glu1062Gln Single submitter ⚠
- p.Glu1298Gly Single submitter ⚠
- p.Glu169Ala Single submitter ⚠
- p.Glu388Gly Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Glu64Asp Single submitter ⚠
- p.Gly10Glu Single submitter ⚠
- p.Gly1285Glu Single submitter ⚠
- p.Gly1401Asp Single submitter ⚠
- p.Gly56Ala Single submitter ⚠
- p.Gly921Glu Single submitter ⚠
- p.His122Pro Single submitter ⚠
- p.His203Arg Single submitter ⚠
- p.Ile1422Lys Single submitter ⚠
- p.Ile40Thr Single submitter ⚠
- p.Ile468Thr Single submitter ⚠
- p.Ile544Val Single submitter ⚠
- p.Ile545Thr Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu442Phe Single submitter ⚠
- p.Lys1215Gln Single submitter ⚠
- p.Lys147Thr Single submitter ⚠
- p.Lys202Arg Single submitter ⚠
- p.Lys487Arg Single submitter ⚠
- p.Lys699Arg Single submitter ⚠
- p.Lys919Thr Single submitter
- p.Met1335Ile Single submitter ⚠
- p.Phe1199Leu Single submitter ⚠
- p.Pro130Ala Single submitter ⚠
- p.Pro361Ser Single submitter
- p.Pro562Ala Single submitter ⚠
- p.Pro60Ser Single submitter ⚠
- p.Ser1093Pro Single submitter ⚠
- p.Ser1290Leu Single submitter ⚠
- p.Ser1290Pro Single submitter
- p.Ser1371Gly Single submitter ⚠
- p.Ser183Gly Single submitter ⚠
- p.Ser443Leu Single submitter ⚠
- p.Ser457Asn Single submitter ⚠
- p.Ser536Ile Single submitter ⚠
- p.Ser546Cys Single submitter ⚠
- p.Ser571Leu Single submitter ⚠
- p.Ser621Gly Single submitter
- p.Ser634Arg Single submitter ⚠
- p.Ser644Gly Single submitter ⚠
- p.Ser659Asn Single submitter ⚠
- p.Ser691Leu Single submitter ⚠
- p.Ser78Asn Single submitter ⚠
- p.Ser837Asn Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Ser928Leu Single submitter ⚠
- p.Thr1271Met Single submitter ⚠
- p.Thr414Ile Single submitter ⚠
- p.Thr456Ala Single submitter ⚠
- p.Thr533Ala Single submitter ⚠
- p.Thr556Ala Single submitter ⚠
- p.Thr611Ile Single submitter ⚠
- p.Thr614Ser Single submitter ⚠
- p.Tyr1009His Single submitter ⚠
- p.Tyr1357Cys Single submitter ⚠
- p.Tyr647Cys Single submitter ⚠
- p.Tyr826Cys Single submitter ⚠
- p.Tyr885His Single submitter
- p.Val1081Ala Single submitter ⚠
- p.Val1089Ile Single submitter ⚠
- p.Val1395Ala Single submitter ⚠
- p.Val1435Leu Single submitter ⚠
- p.Val143fs Single submitter
- p.Val537Phe Single submitter ⚠
- p.Val572Ile Single submitter ⚠
- p.Val612Met Single submitter ⚠
- p.Val640Ala Single submitter ⚠
- p.Val840Ile Single submitter ⚠
- p.Val867Ile Single submitter ⚠