NT5C3B — 30 ClinVar variants
All ClinVar germline NT5C3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Likely benign · 29 Uncertain significance
Full NT5C3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NT5C3B p.Arg260Trp Uncertain significance Single submitter
- NT5C3B p.Arg261Gln Uncertain significance Single submitter
- NT5C3B p.Arg93Gln Uncertain significance Single submitter
- NT5C3B p.Asn111Ser Uncertain significance Single submitter
- NT5C3B p.Asn149Ser Uncertain significance Single submitter
- NT5C3B p.Asp189Asn Uncertain significance Single submitter
- NT5C3B p.Asp239Asn Uncertain significance Single submitter
- NT5C3B p.Asp34His Uncertain significance Single submitter
- NT5C3B p.Cys73Arg Uncertain significance Single submitter
- NT5C3B p.Gln294His Uncertain significance Single submitter
- NT5C3B p.His83Arg Uncertain significance Single submitter
- NT5C3B p.Met102Thr Uncertain significance Single submitter
- NT5C3B p.Met133Leu Uncertain significance Single submitter
- NT5C3B p.Met170Arg Uncertain significance Single submitter
- NT5C3B p.Phe121Leu Uncertain significance Single submitter
- NT5C3B p.Phe153Ser Uncertain significance Single submitter
- NT5C3B p.Phe42Leu Uncertain significance Single submitter
- NT5C3B p.Ser156Pro Uncertain significance Single submitter
- NT5C3B p.Thr223Ser Uncertain significance Single submitter
- NT5C3B p.Tyr146Cys Uncertain significance Single submitter
- NT5C3B p.Tyr60Asp Uncertain significance Single submitter
- NT5C3B p.Tyr84Cys Uncertain significance Single submitter
- NT5C3B p.Val38Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NT5C3B variants
Likely benign 1
- p.Asn131Ser Single submitter
Uncertain significance 29
- p.Ala109Val Single submitter ⚠
- p.Arg260Trp Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asn149Ser Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp239Asn Single submitter ⚠
- p.Asp34His Single submitter ⚠
- p.Cys73Arg Single submitter ⚠
- p.Gln294His Single submitter ⚠
- p.His174Gln Single submitter
- p.His83Arg Single submitter ⚠
- p.Ile87Thr Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Met102Thr Single submitter ⚠
- p.Met133Leu Single submitter ⚠
- p.Met170Arg Single submitter ⚠
- p.Phe121Leu Single submitter ⚠
- p.Phe141Leu Single submitter ⚠
- p.Phe153Ser Single submitter ⚠
- p.Phe42Leu Single submitter ⚠
- p.Ser156Pro Single submitter ⚠
- p.Ser66Cys Single submitter ⚠
- p.Thr223Ser Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Tyr60Asp Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val38Met Single submitter ⚠