NT5M — 37 ClinVar variants
All ClinVar germline NT5M variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Likely benign · 35 Uncertain significance
Full NT5M gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NT5M p.Ala111Thr Uncertain significance Single submitter
- NT5M p.Ala196Thr Uncertain significance Single submitter
- NT5M p.Ala215Val Uncertain significance Single submitter
- NT5M p.Ala35Thr Uncertain significance Single submitter
- NT5M p.Arg226Gln Uncertain significance Single submitter
- NT5M p.Arg34Leu Uncertain significance Single submitter
- NT5M p.Asn100Asp Uncertain significance Single submitter
- NT5M p.Asp216Glu Uncertain significance Single submitter
- NT5M p.Asp63Asn Uncertain significance Single submitter
- NT5M p.Gly26Ser Uncertain significance Single submitter
- NT5M p.Ile180Leu Uncertain significance Single submitter
- NT5M p.Leu172Arg Uncertain significance Single submitter
- NT5M p.Met118Thr Uncertain significance Single submitter
- NT5M p.Met135Val Uncertain significance Single submitter
- NT5M p.Met42Ile Uncertain significance Single submitter
- NT5M p.Met42Thr Uncertain significance Single submitter
- NT5M p.Met42Val Uncertain significance Single submitter
- NT5M p.Phe57Cys Uncertain significance Single submitter
- NT5M p.Pro227Ser Uncertain significance Single submitter
- NT5M p.Trp189Cys Uncertain significance Single submitter
- NT5M p.Trp214Arg Uncertain significance Single submitter
- NT5M p.Val160Glu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- NT5M p.Arg177Trp Uncertain significance Single submitter
- NT5M p.Arg208Cys Uncertain significance Single submitter
- NT5M p.Arg209Cys Uncertain significance Single submitter
- NT5M p.Arg209His Uncertain significance Single submitter
- NT5M p.Arg58His Uncertain significance Single submitter
- NT5M p.Glu184Lys Uncertain significance Single submitter
- NT5M p.Phe136Cys Uncertain significance Single submitter
- NT5M p.Pro206Arg Uncertain significance Single submitter
- NT5M p.Pro206His Uncertain significance Single submitter
- NT5M p.Pro206Leu Uncertain significance Single submitter
- NT5M p.Pro65Ala Uncertain significance Single submitter
- NT5M p.Val112Met Uncertain significance Single submitter
All NT5M variants
Likely benign 2
- p.Cys228Arg Single submitter
- p.Ser120Asn Single submitter
Uncertain significance 35
- p.Ala111Thr Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala215Val Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg208Cys Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg226Trp Single submitter
- p.Arg34Leu Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Asn100Asp Single submitter ⚠
- p.Asp216Glu Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Ile180Leu Single submitter ⚠
- p.Leu172Arg Single submitter ⚠
- p.Met118Thr Single submitter ⚠
- p.Met135Val Single submitter ⚠
- p.Met42Ile Single submitter ⚠
- p.Met42Thr Single submitter ⚠
- p.Met42Val Single submitter ⚠
- p.Phe136Cys Single submitter ⚠
- p.Phe57Cys Single submitter ⚠
- p.Pro206Arg Single submitter ⚠
- p.Pro206His Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro227Ser Single submitter ⚠
- p.Pro65Ala Single submitter ⚠
- p.Trp189Cys Single submitter ⚠
- p.Trp214Arg Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val160Glu Single submitter ⚠