NTMT1 — 29 ClinVar variants
All ClinVar germline NTMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Likely benign · 28 Uncertain significance
Full NTMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NTMT1 p.Ala65Thr Uncertain significance Single submitter
- NTMT1 p.Arg192Lys Uncertain significance Single submitter
- NTMT1 p.Arg46Gln Uncertain significance Single submitter
- NTMT1 p.Arg78Trp Uncertain significance Single submitter
- NTMT1 p.Asn209Lys Uncertain significance Single submitter
- NTMT1 p.Cys195Gly Uncertain significance Single submitter
- NTMT1 p.Glu204Lys Uncertain significance Single submitter
- NTMT1 p.Gly29Ser Uncertain significance Single submitter
- NTMT1 p.Gly32Trp Uncertain significance Single submitter
- NTMT1 p.Gly69Arg Uncertain significance Single submitter
- NTMT1 p.His216Arg Uncertain significance Single submitter
- NTMT1 p.Ile194Asn Uncertain significance Single submitter
- NTMT1 p.Ile23Met Uncertain significance Single submitter
- NTMT1 p.Leu187Phe Uncertain significance Single submitter
- NTMT1 p.Ser196Gly Uncertain significance Single submitter
- NTMT1 p.Ser45Phe Uncertain significance Single submitter
- NTMT1 p.Thr102Ile Uncertain significance Single submitter
- NTMT1 p.Thr62Met Uncertain significance Single submitter
- NTMT1 p.Trp20Cys Uncertain significance Single submitter
- NTMT1 p.Tyr218Cys Uncertain significance Single submitter
- NTMT1 p.Val179Leu Uncertain significance Single submitter
- NTMT1 p.Val189Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- NTMT1 p.Ala197Thr Uncertain significance Single submitter
- NTMT1 p.Arg191Cys Uncertain significance Single submitter
- NTMT1 p.Arg46Trp Uncertain significance Single submitter
- NTMT1 p.Asp95Val Uncertain significance Single submitter
- NTMT1 p.Ile162Phe Uncertain significance Single submitter
- NTMT1 p.Leu202Arg Uncertain significance Single submitter
All NTMT1 variants
Likely benign 1
- p.Arg191His Single submitter
Uncertain significance 28
- p.Ala197Thr Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg192Lys Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Asn209Lys Single submitter ⚠
- p.Asp95Val Single submitter ⚠
- p.Cys195Gly Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.Gly32Trp Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.His216Arg Single submitter ⚠
- p.Ile162Phe Single submitter ⚠
- p.Ile194Asn Single submitter ⚠
- p.Ile23Met Single submitter ⚠
- p.Leu187Phe Single submitter ⚠
- p.Leu202Arg Single submitter ⚠
- p.Ser196Gly Single submitter ⚠
- p.Ser45Phe Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr62Met Single submitter ⚠
- p.Trp20Cys Single submitter ⚠
- p.Tyr218Cys Single submitter ⚠
- p.Val179Leu Single submitter ⚠
- p.Val189Met Single submitter ⚠