NTPCR — 33 ClinVar variants
All ClinVar germline NTPCR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 32 Uncertain significance
Full NTPCR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NTPCR p.Ala2Val Uncertain significance Single submitter
- NTPCR p.Ala92Ser Uncertain significance Single submitter
- NTPCR p.Ala92Thr Uncertain significance Single submitter
- NTPCR p.Ala92Val Uncertain significance Single submitter
- NTPCR p.Arg130Cys Uncertain significance Single submitter
- NTPCR p.Arg3Pro Uncertain significance Single submitter
- NTPCR p.Arg3Trp Uncertain significance Single submitter
- NTPCR p.Asp100Asn Uncertain significance Single submitter
- NTPCR p.Asp84Asn Uncertain significance Single submitter
- NTPCR p.Asp84Gly Uncertain significance Single submitter
- NTPCR p.Gln90His Uncertain significance Single submitter
- NTPCR p.Gly137Arg Uncertain significance Single submitter
- NTPCR p.His20Tyr Uncertain significance Single submitter
- NTPCR p.Leu154Ile Uncertain significance Single submitter
- NTPCR p.Phe50Leu Uncertain significance Single submitter
- NTPCR p.Pro10Ser Uncertain significance Single submitter
- NTPCR p.Pro71Ser Uncertain significance Single submitter
- NTPCR p.Thr132Met Uncertain significance Single submitter
- NTPCR p.Thr135Ile Uncertain significance Single submitter
- NTPCR p.Thr143Arg Uncertain significance Single submitter
- NTPCR p.Val129Ile Uncertain significance Single submitter
- NTPCR p.Val25Ile Uncertain significance Single submitter
- NTPCR p.Val53Ile Uncertain significance Single submitter
- NTPCR p.Val5Leu Uncertain significance Single submitter
- NTPCR p.Val95Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- NTPCR p.Gly30Ala Uncertain significance Single submitter
- NTPCR p.Gly57Ser Uncertain significance Single submitter
- NTPCR p.Pro136Leu Uncertain significance Single submitter
- NTPCR p.Pro61Ser Uncertain significance Single submitter
- NTPCR p.Val31Met Uncertain significance Single submitter
- NTPCR p.Val78Ile Uncertain significance Single submitter
All NTPCR variants
Likely benign 1
- p.Val111Ile Single submitter
Uncertain significance 32
- p.Ala2Val Single submitter ⚠
- p.Ala92Ser Single submitter ⚠
- p.Ala92Thr Single submitter ⚠
- p.Ala92Val Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg3Pro Single submitter ⚠
- p.Arg3Trp Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Asp84Gly Single submitter ⚠
- p.Gln90His Single submitter ⚠
- p.Gly137Arg Single submitter ⚠
- p.Gly30Ala Single submitter ⚠
- p.Gly57Ser Single submitter ⚠
- p.His20Tyr Single submitter ⚠
- p.Ile115Thr Single submitter
- p.Leu154Ile Single submitter ⚠
- p.Phe50Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro71Ser Single submitter ⚠
- p.Thr132Met Single submitter ⚠
- p.Thr135Ile Single submitter ⚠
- p.Thr143Arg Single submitter ⚠
- p.Val129Ile Single submitter ⚠
- p.Val25Ile Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val53Ile Single submitter ⚠
- p.Val5Leu Single submitter ⚠
- p.Val78Ile Single submitter ⚠
- p.Val95Ile Single submitter ⚠