NTSR2 — 73 ClinVar variants

All ClinVar germline NTSR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →

1 Conflicting · 1 Benign · 7 Likely benign · 64 Uncertain significance

Full NTSR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 64

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

NTSR2 p.Arg253Ser Conflicting Single submitter

Predictors lean, ClinVar uncertain 52

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All NTSR2 variants

Conflicting classifications of pathogenicity 1

p.Arg253Ser Single submitter ⚠

Benign 1

p.Arg282Lys Multiple submitters

Likely benign 7

p.Ala372= Single submitter
p.Arg288Gln Single submitter
p.Arg294His Single submitter
p.Arg64= Single submitter
p.Met305Val Single submitter
p.Pro246Leu Single submitter
p.Pro388= Single submitter

Uncertain significance 64

p.Ala190Thr Single submitter ⚠
p.Ala327Val Single submitter ⚠
p.Ala360Thr Single submitter ⚠
p.Ala47Val Single submitter ⚠
p.Ala62Thr Single submitter ⚠
p.Ala65Thr Single submitter ⚠
p.Arg153Trp Single submitter ⚠
p.Arg192Gln Single submitter ⚠
p.Arg22Gln Single submitter ⚠
p.Arg253Cys Single submitter ⚠
p.Arg287Cys Single submitter ⚠
p.Arg287His Single submitter ⚠
p.Arg288Trp Single submitter ⚠
p.Arg316Cys Single submitter ⚠
p.Arg385Gln Single submitter ⚠
p.Arg385Trp Single submitter ⚠
p.Arg409Gln Single submitter ⚠
p.Arg64Leu Single submitter ⚠
p.Arg69Ser Single submitter ⚠
p.Asp105Glu Single submitter ⚠
p.Asp326Asn Single submitter ⚠
p.Gln139Pro Single submitter ⚠
p.Glu132Lys Single submitter ⚠
p.Glu90Gln Single submitter ⚠
p.Gly107Val Single submitter ⚠
p.Gly24Asp Single submitter ⚠
p.Gly401Ser Single submitter ⚠
p.His55Arg Single submitter ⚠
p.His98Arg Single submitter ⚠
p.Leu129Arg Single submitter
p.Leu147Pro Single submitter ⚠
p.Leu197Val Single submitter ⚠
p.Leu212Met Single submitter ⚠
p.Leu346Phe Single submitter ⚠
p.Leu34Pro Single submitter ⚠
p.Leu45Pro Single submitter ⚠
p.Leu52Pro Single submitter ⚠
p.Leu82Pro Single submitter ⚠
p.Lys32Met Single submitter ⚠
p.Met174Thr Single submitter ⚠
p.Pro218Ser Single submitter ⚠
p.Pro246Arg Single submitter ⚠
p.Pro312Leu Single submitter ⚠
p.Pro382Ser Single submitter ⚠
p.Pro382Thr Single submitter ⚠
p.Pro387Ser Single submitter ⚠
p.Pro406Thr Single submitter ⚠
p.Pro6Leu Single submitter ⚠
p.Pro8Ser Single submitter ⚠
p.Ser125Arg Single submitter ⚠
p.Ser163Leu Single submitter ⚠
p.Ser295Gly Single submitter ⚠
p.Ser4Arg Single submitter ⚠
p.Thr271Ile Single submitter ⚠
p.Trp96Cys Single submitter ⚠
p.Tyr120His Single submitter ⚠
p.Tyr348Cys Single submitter ⚠
p.Tyr358His Single submitter ⚠
p.Val267Ile Single submitter ⚠
p.Val303Met Single submitter ⚠
p.Val353Ala Single submitter ⚠
p.Val373Ile Single submitter ⚠
p.Val87Leu Single submitter ⚠
p.Val95Leu Single submitter ⚠